Zhulab_PITT
@bokaizhulab.bsky.social
Our lab is broadly interested in studying the functions of proteostasis dynamics, oscillations, and nuclear condensates in aging and diseases.
Pinned
Zhulab_PITT
@bokaizhulab.bsky.social
· Aug 5
SON-dependent nuclear speckle rehabilitation alleviates proteinopathies - Nature Communications
Here the authors show that rehabilitating nuclear speckles, membraneless organelles involved in mRNA processing and gene regulation, can boost protein quality control and reduce toxic protein buildup,...
www.nature.com
It was a great please to share our most recent work on ‘rejuvenating’ nuclear speckles to alleviate proteinopathies. www.nature.com/articles/s41...
link.springer.com/article/10.1....
Hepatic metabolic functions follow a 12-hour cycle rather than a 24-hour cycle, significantly contributing to the liver’s ability to meet nutrient demands throughout the day!!
Hepatic metabolic functions follow a 12-hour cycle rather than a 24-hour cycle, significantly contributing to the liver’s ability to meet nutrient demands throughout the day!!
Client Challenge
link.springer.com
January 9, 2026 at 6:43 PM
link.springer.com/article/10.1....
Hepatic metabolic functions follow a 12-hour cycle rather than a 24-hour cycle, significantly contributing to the liver’s ability to meet nutrient demands throughout the day!!
Hepatic metabolic functions follow a 12-hour cycle rather than a 24-hour cycle, significantly contributing to the liver’s ability to meet nutrient demands throughout the day!!
It was a great please to share our most recent work on ‘rejuvenating’ nuclear speckles to alleviate proteinopathies. www.nature.com/articles/s41...
SON-dependent nuclear speckle rehabilitation alleviates proteinopathies - Nature Communications
Here the authors show that rehabilitating nuclear speckles, membraneless organelles involved in mRNA processing and gene regulation, can boost protein quality control and reduce toxic protein buildup,...
www.nature.com
August 5, 2025 at 2:28 PM
It was a great please to share our most recent work on ‘rejuvenating’ nuclear speckles to alleviate proteinopathies. www.nature.com/articles/s41...
www.pittmed.pitt.edu/news/12-hour.... It is a nice news piece on our earlier work demonstrating the existence of 12h rhythms in ‘free-living’ humans.
Left by the tides
Traces of ocean-dwelling ancestors seem to live on in our biological rhythms.
www.pittmed.pitt.edu
July 10, 2025 at 10:54 PM
www.pittmed.pitt.edu/news/12-hour.... It is a nice news piece on our earlier work demonstrating the existence of 12h rhythms in ‘free-living’ humans.
It is a great review!!
It was very interesting to write this review article about 12hr rhythms in marine species and mammals. Almots 20 years after the first description of these 12hr rhythms in mouse liver, we still don't know a lot about their role and their regulation!
rdcu.be/epdti
rdcu.be/epdti
Biological rhythms: Living your life, one half-day at a time
npj Biological Timing and Sleep - Biological rhythms: Living your life, one half-day at a time
rdcu.be
June 4, 2025 at 2:36 PM
It is a great review!!