Bora Gurel, MD, Ph.D
@boragurel.bsky.social
Computational pathologist, specializing in Uropathology. AÜTF ‘01, HÜTF ‘07, JHU ‘11, ICR '23. Ex-Doçent. Views most definitely my own. Occasional #Formula1 posts 😉 Clinician Scientist in the De Bono lab #pathsky #medsky
Awesome, can't wait to complete the set! 🥰
February 20, 2025 at 8:10 AM
Awesome, can't wait to complete the set! 🥰
The classics never get old. A very happy holiday season to all. 😊
December 24, 2024 at 8:12 PM
The classics never get old. A very happy holiday season to all. 😊
Dataset is exported to stats analysis environment, cells of interest are reconstructed as datapoints and distances calculated:
November 18, 2024 at 9:51 AM
Dataset is exported to stats analysis environment, cells of interest are reconstructed as datapoints and distances calculated:
Cells of interest identified, X-Y coordinates marked:
November 18, 2024 at 9:37 AM
Cells of interest identified, X-Y coordinates marked:
Cells detected and analysed for IF marker intensity, this overlay is for all markers combined:
November 18, 2024 at 9:37 AM
Cells detected and analysed for IF marker intensity, this overlay is for all markers combined:
Same image, with only markers of interest. Blue is cell nuclei, purple and green are the two cell markers we're interested in:
November 18, 2024 at 9:37 AM
Same image, with only markers of interest. Blue is cell nuclei, purple and green are the two cell markers we're interested in:
I have been following @davekellett.bsky.social 's work for over 15 years now and could not recommend DRIVE highly enough. A must read for any sci-fi fan!
November 16, 2024 at 8:33 PM
I have been following @davekellett.bsky.social 's work for over 15 years now and could not recommend DRIVE highly enough. A must read for any sci-fi fan!
Post a picture of yourself to show the newbies what they're dealing with 😁
November 16, 2024 at 7:02 PM
Post a picture of yourself to show the newbies what they're dealing with 😁
Each cell in the image is detected by yet another deep learning algorithm, which looks at the shape of each cell nucleus and decides if it is malignant or benign. Red cells are malignant, blue are benign, light blue are immune cells and green are stromal cell nuclei.
#pathsky #science #medsky 🧪
#pathsky #science #medsky 🧪
November 11, 2024 at 12:16 PM
The slide is then digitized with a scanner, and a deep-learning algorithm (trained by yours truly) then detects and annotates different types of tissue. Here, red is tumour, light blue is benign, green is stroma and yellow is empty areas.
We used to do this by hand 😭
#pathsky #science #medsky 🧪
We used to do this by hand 😭
#pathsky #science #medsky 🧪
November 11, 2024 at 12:16 PM
How deep learning assists scientists in characterising tissue, a story in a few parts:
Tumour tissue is stained with a large number of fluorescent antibodies, each detecting a specific protein that assists in naming (phenotyping) each cell. Each blue blob is one cell.
#pathsky #science #medsky 🧪
Tumour tissue is stained with a large number of fluorescent antibodies, each detecting a specific protein that assists in naming (phenotyping) each cell. Each blue blob is one cell.
#pathsky #science #medsky 🧪
November 11, 2024 at 12:16 PM
Science can be beautiful: +25-antibody hyperplex immunofluorescence, allows us to visualize a lot of proteins in tumour tissue all at once. You can then run deep learning-based image analysis routines to examine how different kinds of immune cells respond to cancer. #pathsky #science #medsky
November 10, 2024 at 2:06 AM
Our lab does a lot of IF, which often result in some pretty stunning images:
October 22, 2024 at 10:13 AM
Our lab does a lot of IF, which often result in some pretty stunning images: