PIKfyve inhibition glues protrudin (grayscale, top row), an ER transmembrane protein, to lysosomes. This disturbs the ER morphology and dynamics. If the FYVE domain of protrudin (bottom row) is mutated, these rings go away and ER morphology recovers.

As macrophages engulf many particles, as shown by this scanning EM image, eventually they reach a limit and arrest their appetite for further phagocytosis. But how do they encode this appetite fatigue? That's the key question that we tried to answer this work.