@bowmanlab-jhu.bsky.social
Reposted
New collaborative paper between JPArmache and Bowman (@bowmanlab-jhu.bsky.social) labs show how the yeast CHD1 chromatin remodeler depends on activator elements to distort nucleosomal DNA. This explains how the NegC inhibitor blocks activity. www.nature.com/articles/s41...
A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA - Nature Structural & Molecular Biology
Nodelman, Folkwein et al. define a regulatory region in Chd1 containing adjacent inhibitor and activator elements that compete for binding to the remodeler ATPase. The competition between these elemen...
www.nature.com
May 30, 2025 at 2:35 PM
New collaborative paper between JPArmache and Bowman (@bowmanlab-jhu.bsky.social) labs show how the yeast CHD1 chromatin remodeler depends on activator elements to distort nucleosomal DNA. This explains how the NegC inhibitor blocks activity. www.nature.com/articles/s41...
Reposted
We coupled in depth mutagenesis and biochemistry with high-resolution cryoEM, obtaining maps ranging from 2.37 to 2.9 Å.
This work was done by Ilana Nodelman (Bowman lab) and Heather Folkwein (Armache lab)
Thank you to everyone involved. It was a fun joint-venture!
This work was done by Ilana Nodelman (Bowman lab) and Heather Folkwein (Armache lab)
Thank you to everyone involved. It was a fun joint-venture!
May 30, 2025 at 3:12 PM
We coupled in depth mutagenesis and biochemistry with high-resolution cryoEM, obtaining maps ranging from 2.37 to 2.9 Å.
This work was done by Ilana Nodelman (Bowman lab) and Heather Folkwein (Armache lab)
Thank you to everyone involved. It was a fun joint-venture!
This work was done by Ilana Nodelman (Bowman lab) and Heather Folkwein (Armache lab)
Thank you to everyone involved. It was a fun joint-venture!