Lightnews — Scholar-powered news

Reposted by Brain

Masud Husain @masudhusain.bsky.social · 3d

The current environment is making it near impossible to run clinical trials in the UK.
One key issue discussed in @brain1878.bsky.social
is the duplication - or worse - of regulatory oversight at NHS hospitals & universities.

My views on how to change the system
academic.oup.com/brain/articl...

12 22

Brain @brain1878.bsky.social · 1d

Pruckner et al. show that the structural effects of neurosurgery extend beyond the resected tissue into connected networks through transneuronal degeneration. They were able to reliably predict these changes from preoperative MRI. tinyurl.com/a6rxvbey

Brain @brain1878.bsky.social · 4d

New issue of Brain now online! tinyurl.com/mwxp6x24

1

Brain @brain1878.bsky.social · 5d

Avalos-Alais et al. present a high-resolution probabilistic map of bidirectional effective connectivity between the human lateral PFC and widespread cortical and subcortical regions, based on analysis of intracranial evoked potentials. tinyurl.com/br7htec9

Brain @brain1878.bsky.social · 19d

Mongay-Ochoa et al. review advanced methods for mapping brain connections and identify common topographical patterns of pathology spread across different neurological disorders, including MS, AD and PD. tinyurl.com/3sz8ayup

1

Brain @brain1878.bsky.social · 21d

Research into mental imagery often relies on Hume’s view of visual imagination as weak perception. Arcangeli & Bartolomeo argue that Sartre’s alternative framework – supported by recent findings on aphantasia – offers a more conceptually robust approach. tinyurl.com/n2k3md9e

1 1

Brain @brain1878.bsky.social · 25d

Pansieri et al. argue that bureaucracy is suffocating research, as an ever increasing admin burden consumes researchers’ time and diverts focus from discovery to compliance. tinyurl.com/ybv5e9ft

1 1

Brain @brain1878.bsky.social · Sep 8

Using tau PET and post-mortem data from individuals with five clinical variants of AD, de Bruin et al. show that tau progression follows the brain’s intrinsic functional connectivity architecture, originating from local epicentres. tinyurl.com/bdfprjcn

2

Reposted by Brain

Katrin Pape @katrinpape.bsky.social · Aug 26

Excited to see our paper on the CD5 signalling pathway in Th17 cells and its role in #MultipleSclerosis out in @brain1878.bsky.social today. Thanks to everyone involved in this great team work! @neurologymainz.bsky.social @toszkabohn.bsky.social #ImmunoSky
academic.oup.com/brain/advanc...

Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis

Pape et al. link the CD5-CK2-STAT3 signalling pathway to both inflammation and effector function in multiple sclerosis, using a multi-modal approach that c

academic.oup.com

1 3 5

Brain @brain1878.bsky.social · Sep 3

September's issue of Brain is now online! academic.oup.com/brain/issue/...

Brain @brain1878.bsky.social · Aug 29

Abreaction was once a common treatment for functional neurological disorder (FND) but has since fallen out of use. Norman Poole argues that abreaction is compatible with many findings from modern neuroscience, and should be tested as a treatment for FND. tinyurl.com/fcjpywx2

1

Reposted by Brain

Jacob Vorstman @jacobvorstman.bsky.social · Aug 12

Super stoked to share our paper just out in Brain @brain1878.bsky.social
LoF variants in DENND2B give rise to an autosomal dominant neurodevelopmental condition characterized by developmental delay, intellectual disability, and episodes of psychosis and/or catatonia. tinyurl.com/4k8hr3bj

Variants in DENND2B are associated with vulnerability for neurodevelopmental impairment, psychosis and catatonia

Murthy et al. report that monoallelic loss of function variants in the DENND2B gene give rise to an autosomal dominant neurodevelopmental disorder characte

tinyurl.com

1 1

Brain @brain1878.bsky.social · Aug 11

From signal to senescence: IFNγ drives muscle atrophy in myositis

New scientific commentary by Werner Stenzel et al. tinyurl.com/33hwhd8f

Brain @brain1878.bsky.social · Aug 8

Arena et al. show that a history of TBI or repetitive head impacts from contact sports is associated with widespread tau pathology within glial cells, beyond that of chronic traumatic encephalopathy. tinyurl.com/h658b3f2

2

Brain @brain1878.bsky.social · Aug 4

August's issue of Brain is now online! academic.oup.com/brain/issue/...

1

Brain @brain1878.bsky.social · Jul 28

Yogeshwar et al. present clinical and MRI data from 127 patients with anti-IgLON5 disease. They show brain atrophy patterns that closely mirror sites of autoantibody binding and tau accumulation, with the location of atrophy linked to specific symptoms. tinyurl.com/3u4ufv2z

1

Brain @brain1878.bsky.social · Jul 22

Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts, and show that iNSCs can differentiate into mature oligodendrocytes and remyelinate axons in demyelinated lesions. tinyurl.com/3a2auah5

1 1

Brain @brain1878.bsky.social · Jul 21

Disentangling epilepsy and dementia: more to do, together

New scientific commentary by Arjune Sen tinyurl.com/mr44jt9b

1 1

Reposted by Brain

Rimona Weil @rimonaweil.bsky.social · Jul 8

I’m delighted to share my editorial for the July issue @brain1878.bsky.social academic.oup.com/brain/articl...

Seeing the trees in the wood: the importance of co-pathologies in Alzheimer’s disease and dementia with Lewy bodies

Our understanding of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) owes a debt to pioneering work by Emil Kraepelin, Franz Nissl, Alois Alzh

academic.oup.com

10 19

Brain @brain1878.bsky.social · Jul 18

Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance. tinyurl.com/3b7msy45

Brain @brain1878.bsky.social · Jul 17

Medial temporal lobe structural changes when Down syndrome and Alzheimer’s disease collide

New scientific commentary by Laura Wisse and Renaud La Joie tinyurl.com/345u5r3w

Brain @brain1878.bsky.social · Jul 16

The converging paths to hippocampal sclerosis of ageing: insights from LATE-NC and vascular disease

New scientific commentary by Ryan Coburn and Hugo Botha tinyurl.com/3ffhrkm7

Brain @brain1878.bsky.social · Jul 15

Kazazian et al. review the use of neuroimaging in disorders of consciousness, detailing key methods (fMRI, EEG, PET) and imaging paradigms that can be used to improve diagnosis and prognosis. tinyurl.com/bddyanm4

2 2

Reposted by Brain

Center for Molecular Integrative Neuroresilience @icahncmin.bsky.social · Jul 10

In a NEW STUDY, researchers Chaitali Anand, Justin Torok,, Ashish Raj, et al. at UCSF reveal how genes influence where & how #Alzheimers - related tau protein spreads in the brain. Learn More @brain1878.bsky.social academic.oup.com/brain/advanc...

Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome

Anand et al. show that Alzheimer's disease risk genes confer vulnerability or resilience to tau pathology through both network-dependent and independent me

academic.oup.com

1 2

Brain @brain1878.bsky.social · Jul 12

Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance. tinyurl.com/3b7msy45