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Reposted by Center for Brain Circuit Therapeutics

Andreas Horn @andreashorn.org · Sep 3

In #DeepBrainStimulation

the two major developments across the last decade have been

1. Adaptive DBS and
2. Connectomic DBS

In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:

Could the two be united into a common framework?

www.nature.com/articles/s41...

A 🧵

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Reposted by Center for Brain Circuit Therapeutics

Lead-DBS @lead-dbs.org · Sep 3

From Adaptive DBS to Adaptive Circuit Targeting 👇👇

Andreas Horn @andreashorn.org · Sep 3

In #DeepBrainStimulation

the two major developments across the last decade have been

1. Adaptive DBS and
2. Connectomic DBS

In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:

Could the two be united into a common framework?

www.nature.com/articles/s41...

A 🧵

2 2

Reposted by Center for Brain Circuit Therapeutics

Stimulating Brains @stimulatingbrains.org · Sep 3

Next steps ahead for DBS! 👇👇

Andreas Horn @andreashorn.org · Sep 3

In #DeepBrainStimulation

the two major developments across the last decade have been

1. Adaptive DBS and
2. Connectomic DBS

In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:

Could the two be united into a common framework?

www.nature.com/articles/s41...

A 🧵

3 3

Reposted by Center for Brain Circuit Therapeutics

Network Stimulation Institute @netstim.org · Sep 3

One of our "bigger visions" for the next years summarized in a neat perspective paper out now 👇👇

Andreas Horn @andreashorn.org · Sep 3

In #DeepBrainStimulation

the two major developments across the last decade have been

1. Adaptive DBS and
2. Connectomic DBS

In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:

Could the two be united into a common framework?

www.nature.com/articles/s41...

A 🧵

1 1

Reposted by Center for Brain Circuit Therapeutics

Lead-DBS @lead-dbs.org · Aug 22

How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:

academic.oup.com/braincomms/a...

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Reposted by Center for Brain Circuit Therapeutics

Andreas Horn @andreashorn.org · Aug 22

Konstantin Butenko compares four methods for mapping structural network activations in deep brain stimulation—two simple, two complex; some deterministic, some probabilistic—into @lead-dbs.org for direct use in the Fiber Filtering Explorer. See the methods paper below 👇👇

Lead-DBS @lead-dbs.org · Aug 22

How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:

academic.oup.com/braincomms/a...

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Reposted by Center for Brain Circuit Therapeutics

Michael Fox @foxmdphd.bsky.social · Aug 19

Sending off 2 of our best research assistants ‬to graduate programs that are lucky to have them. Congrats Grace and Jessy and we look forward to your ongoing success! @braincircuits.bsky.social

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Reposted by Center for Brain Circuit Therapeutics

Michael Fox @foxmdphd.bsky.social · Jul 21

Honored to highlight our work @braincircuits.bsky.social @massgenbrigham.bsky.social Neuro Research Day. Thank you @shansiddiqi.bsky.social @fredschaper.bsky.social Sheena Baratano and Sam Snider for sharing your experience.

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Reposted by Center for Brain Circuit Therapeutics

Michael Fox @foxmdphd.bsky.social · Jul 21

Is there a brain circuit target for restoring consciousness after brain injury? New work by @rolstonjohn.bsky.social @braincircuits.bsky.social says yes!

John Rolston @rolstonjohn.bsky.social · Jul 21

Just dropped in @natcomms.nature.com: we show that re-engaging a thalamic–ventral tegmental circuit with deep brain stimulation can reignite consciousness in patients with severe brain injury. Work led by Aaron Warren, with @andreashorn.org @foxmdphd.bsky.social @ others! tinyurl.com/4kz8j89b

A human brain network linked to restoration of consciousness after deep brain stimulation - Nature Communications

In people with severe brain injuries, stimulation restored consciousness by engaging a deep brain circuit for wakefulness—revealing a target that may also guide treatment in stroke and epilepsy.

www.nature.com

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Reposted by Center for Brain Circuit Therapeutics

Andreas Horn @andreashorn.org · Aug 1

How may traveling waves in the brain impact seizure focus detection in functional neurosurgery?
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?

Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇

Stimulating Brains @stimulatingbrains.org · Aug 1

We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇

stimulatingbrains.org/72-john-rols...

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Reposted by Center for Brain Circuit Therapeutics

Stimulating Brains @stimulatingbrains.org · Aug 1

We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇

stimulatingbrains.org/72-john-rols...

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Reposted by Center for Brain Circuit Therapeutics

Andreas Horn @andreashorn.org · Jun 24

Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇

Lauren Hart @laurenahart.bsky.social · Jun 24

🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...

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Reposted by Center for Brain Circuit Therapeutics

Lauren Hart @laurenahart.bsky.social · Jun 24

🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...

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Reposted by Center for Brain Circuit Therapeutics

Isaiah Kletenik @isaiahneuro.bsky.social · Jun 11

Can a brain injury lead someone to commit a crime?

Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @braincircuits.bsky.social @foxmdphd.bsky.social
www.nature.com/articles/s41...

White matter disconnection in acquired criminality - Molecular Psychiatry

Molecular Psychiatry - White matter disconnection in acquired criminality

www.nature.com

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Reposted by Center for Brain Circuit Therapeutics

Alexander Li Cohen @drdrxanderli.bsky.social · Jun 17

Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover!
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....

@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social

Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review

Objective Attention-deficit/hyperactivity disorder (ADHD) has been associated with decreased regional brain volume, yet no consistent localization has emerged across studies. This discrepancy has be...

onlinelibrary.wiley.com

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Reposted by Center for Brain Circuit Therapeutics

Andreas Horn @andreashorn.org · Jun 20

We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested!

lnkd.in/eEbnXByJ

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Center for Brain Circuit Therapeutics @braincircuits.bsky.social · Jun 2

10,000! 🎂🍰 💯x💯!

Andreas Horn @andreashorn.org · Jun 2

@foxmdphd.bsky.social's legendary anticorrelation paper has now been cited over 10.000 times and this was reason for a dedicated PNAS cake. Congratulations again, Mike, for this unbelievable pioneering effort that opened up the then novel field of resting-state fMRI!

@braincircuits.bsky.social

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Reposted by Center for Brain Circuit Therapeutics

Andreas Horn @andreashorn.org · May 30

What a number!

🔜 🎉🥳🎊🍾 @foxmdphd.bsky.social!

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Reposted by Center for Brain Circuit Therapeutics

Network Stimulation Institute @netstim.org · May 29

Hard to keep track about all the great things our labmembers have achieved recently:

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Reposted by Center for Brain Circuit Therapeutics

Stimulating Brains @stimulatingbrains.org · May 29

Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively.

Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET

Register here: partners.zoom.us/webinar/regi...

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Reposted by Center for Brain Circuit Therapeutics

Network Stimulation Institute @netstim.org · May 29

Join us today! 👇👇

Stimulating Brains @stimulatingbrains.org · May 29

Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively.

Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET

Register here: partners.zoom.us/webinar/regi...

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Reposted by Center for Brain Circuit Therapeutics

Michael Okun @michaelokun.bsky.social · May 24

Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?

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Reposted by Center for Brain Circuit Therapeutics

Isaiah Kletenik @isaiahneuro.bsky.social · May 23

Can brain injury cause the loss of visual imagination?

We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social

www.medrxiv.org/content/10.1...

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Reposted by Center for Brain Circuit Therapeutics

Michael Fox @foxmdphd.bsky.social · May 24

Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES

Lukas Goede @lukasgoede.bsky.social · May 22

Tremor is a common symptom across many neurological disorders.

But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?

We think: yes.

Our study is out now in @natcomms.nature.com:

🔗 www.nature.com/articles/s41...

🧵 A thread.

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Reposted by Center for Brain Circuit Therapeutics

The Science of Parkinson's @scienceofpd.bsky.social · May 23

New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor
www.nature.com/articles/s41...

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