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Brenda Raud @brendaraud.bsky.social · 14d

More than 100 minutes… so between 1.5-2 hours of material? doesn’t sound like sufficient data to make any meaningful conclusions 🤷‍♀️

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Brenda Raud @brendaraud.bsky.social · Aug 23

thanks! it was great to meet you too, see you at the next conference!

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Brenda Raud @brendaraud.bsky.social · Aug 23

... but before leaving Vienna, I couldn't resist some local #patisserie 🍰 Just... glorious.

Brenda Raud @brendaraud.bsky.social · Aug 23

thanks @iuisjuniorcomm.bsky.social for inviting us to their career fair where I had a chance to talk about how I got started with my #sci_comm gig! I loved the discussion afterwards

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Brenda Raud @brendaraud.bsky.social · Aug 23

So long, Vienna! I'm back home in Amsterdam after a great week of #immunology at #IUIS2025! I had an amazing time! Check out @immunologypodcast.com for daily episodes covering our favorite talks & recording of the live episode! Thanks @iuis-online.bsky.social! See you all in Toronto #IUIS2028

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Brenda Raud @brendaraud.bsky.social · Aug 23

Cool abstract talks from Charlotte Zajc @meduniwien.ac.at about engineering CARs with ON- and OFF-switches modulated by small molecules & Carolina Mangana @cemm.oeaw.ac.at about changes in tumor-draining LNs brought up by increased myeloid (Mo/Mac) infiltration and loss of T cell zone
#IUIS2025

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Brenda Raud @brendaraud.bsky.social · Aug 23

Gabriel is opening a new lab in #Barcelona with support of @caixaresearch.bsky.social - and they are hiring!

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Brenda Raud @brendaraud.bsky.social · Aug 23

Next in the session: Gabriel Rabinovich (@University of Buenos Aires)☝️ Galectin 1 promotes tumor growth in many ways, such interaction w/ VEGFR2 to promote angiogenesis (resistant to anti-VEGF therapy) & enhancement of myeloid suppressor cells 💡GAL1-neutralizing mAb could help.
#IUIS2025

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Brenda Raud @brendaraud.bsky.social · Aug 22

The band was awesome! Looking forward to their next tour date #IUIS2028 🎶
@iuis-online.bsky.social make sure to book them well in advance, I am sure these musicians are in high demand 🤣

European Journal of Immunology @eurjimmunol.bsky.social · Aug 22

Awesome performance of the band composed of great immunologists, including our Editor-in-Chief Matteo Iannacone behind the keyboard, at the #IUIS2025 Congress Party! 🎹🎸🎶

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Brenda Raud @brendaraud.bsky.social · Aug 22

Another daily episode is out! Our highlights from yesterday's sessions
@immunologypodcast.com @iuis-online.bsky.social #IUIS2025

Immunology Podcast @immunologypodcast.com · Aug 22

We have a new episode out!

Brenda and Jason summarize the research presented yesterday at #IUIS2025, including sessions on cancer immunotherapy and #neuroimmunology.

Listen now: https://bit.ly/41Sb1sQ

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Reposted by Brenda Raud

British Society for Immunology @britsocimm.bsky.social · Aug 22

🔬 Struggling to design multiparametric #flow #cytometry experiments?

Learn how to cut through the complexity and build experiments that work in our training course with @ddcytometry.bsky.social, taking place on 17 & 24 September.

⏳ Just weeks away! Secure your spot today: bit.ly/43N86mG

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Brenda Raud @brendaraud.bsky.social · Aug 22

... 2️⃣ Logic-gating: IF-BETTER gates target 2 antigens-> enhanced activity when primary Ag expression low 3️⃣ inactivating mutation of 2/3 of CD3 ITAM domains improves CAR-T cell persistence w/o affecting function - only 25M dose sufficient for protective response in B cell lymphoma

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Brenda Raud @brendaraud.bsky.social · Aug 22

#IUIS2025 Day 5! Time flies when having fun! Started the day w/ excellent talk from Michael Sadelain @columbiacancer.bsky.social about the current state of CAR T cell therapy and exciting approaches 1️⃣ HLA-independent TCRs interact with CD3 molecules for increased sensitivity and work in low Ag...

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Brenda Raud @brendaraud.bsky.social · Aug 22

Also in the #neuroimmunology session: David Hafler @yaleschoolofmed.bsky.social - IFNg+CD4 cells in brain: come from gut, similar to WAT T cells, affect behavior / increased infiltration in early Parkinson's brain precedes symptoms - could targeting this inflammation be key to prevent progression?

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Reposted by Brenda Raud

Immunology Podcast @immunologypodcast.com · Aug 21

A huge thank-you to Dr. Zwi Berneman for joining us for this special show at #IUIS2025, and thanks to everyone who came to listen!

If you missed it, the episode will be published on podcast platforms next week!

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Reposted by Brenda Raud

Immunology Podcast @immunologypodcast.com · Aug 20

You can see how happy we were to see Dr. James Allison in person at #IUIS2025! 😁

We had the pleasure of speaking with Dr. Allison in 2024. Listen to the conversation here: https://bit.ly/47EUFYm

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Brenda Raud @brendaraud.bsky.social · Aug 21

just look at those little buddies interacting in vitro! #neuroimmunology

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Brenda Raud @brendaraud.bsky.social · Aug 21

@iuis-online.bsky.social #IUIS2025 Day 4! reporting for the @immunologypodcast.com Started the day w/ neuro immunology session - cool story from Ulrich von Andrian @harvardmed.bsky.social -> close interaction of dermal DCs and nociceptive neurons in dermatitis & myeloid suppressor cells in cancer

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Brenda Raud @brendaraud.bsky.social · Aug 21

Also on #IUIS2025 Day 3: keynote by Ruslan Medzhitov. Pet shop mice have pre-existing immunity (look at the size of those LNs!) and a crowded "antigenic space" with Th1/17/reg immunity. Allergic sensitization in SPF mice is possible because the antigenic space is available for full blown Th2

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Brenda Raud @brendaraud.bsky.social · Aug 21

Next up: BRAIN EATING AMOEBA 😱 - Ashley Moseman from @duke-university.bsky.social: N. fowleri infection starts through olfactory nerves 👃 and because complement proteins: ❌ can't cross blood-olfactory barrier ❌ can't mark amoeba for neutrophil attack, pathogen 🦠 reaches brain ahead of immune cells 😵

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Brenda Raud @brendaraud.bsky.social · Aug 21

Check out their pre-print! www.biorxiv.org/content/10.1...

Replaying germinal center evolution on a quantified affinity landscape

Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...

www.biorxiv.org

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Brenda Raud @brendaraud.bsky.social · Aug 21

Later on: @victora.bsky.social at RockefellerU used brainbow mice to study BCR evolution in individual GCs - tl;dr: GCs mostly do mutations that are easy, not most enhancing/ GCs are intolerant to loss of affinity / clonal bursts are not main drivers: rather slow evolution biased to higher affinity

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Brenda Raud @brendaraud.bsky.social · Aug 21

I loved seeing the story from @iannaconelab.bsky.social presented live! HBV-infected hepatocytes can prime CD8 cells directly but CD4 help -> Kupffer cells (not DCs) -> CD27 is needed to prevent dysfunction (check episode #109 of @immunologypodcast.com for the full story!)

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Brenda Raud @brendaraud.bsky.social · Aug 20

Day 3 #IUIS2025 @immunologypodcast.com
Lost a pair of pants and was late to the 1st session of today 🥲 - but enjoyed a masterclass on immune suppression after severe illness from Laura Cook @Peter Doherty Institute - finished strong w/cute organoid-derived pineapple shaped cilliated cells

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Brenda Raud @brendaraud.bsky.social · Aug 19

#IUIS2025 Rising Stars: Thomas Krausgruber (@cemm.oeaw.ac.at ) w/ role of structural cells in response to acute/chronic LCMV infecions, Thomas Vogl (@meduniwien.ac.at) dramatic changes in Ab repertoires in 1y of life & @kedmiranit.bsky.social on interacting Rorgt+ APC and pTregs in oral tolerance.

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