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brightgiant.bsky.social
Bright Giant
@brightgiant.bsky.social
62 followers 57 following 91 posts
We want to establish the identification of unknown small molecules:
Profound algorithms and state-of-the-art machine learning software solutions for small molecule mass spectrometry analysis.
https://bright-giant.com/
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brightgiant.bsky.social
Unlocking the secrets of healing mushrooms 🍄
#SIRIUS6 was instrumental in detailing the metabolic basis for the production of sesquiterpenoids in the #MedicinalMushrooms Sanghuangporus.

#SIRIUSDiscoveries #NaturalProducts

💡 More SIRIUS discoveries: buff.ly/HP0dTWO
📄 Publication: buff.ly/RDAMNtB
December 4, 2025 at 8:29 AM
brightgiant.bsky.social
Fun Fact: Different from stated in the article, SIRIUS is the acronym for “Sum formula Identification by Ranking Isotope patterns Using mass Spectrometry”, originating from our very first approaches in the direction of small molecular annotation.
December 2, 2025 at 8:52 AM
brightgiant.bsky.social
Hidden Players in Drug Efficacy: Using #SIRIUS6, researchers decoded the crucial role of the gut microbiome in altering the chemical structure and efficacy of GPCR drugs.
💡 Blog post: buff.ly/WtrJf2m (5 min)
📄 Publication: buff.ly/8o1ekPv

#SIRIUSDiscoveries #DrugMetabolism #PersonalizedMedicine
December 2, 2025 at 8:52 AM
brightgiant.bsky.social
Based on this tutorial our software #SIRIUS6 plays a significant role in prioritization strategies for #NonTargetScreening in environmental samples by generating molecular fingerprints which are used for compound identification or toxicity prediction.

📄 Read the tutorial: buff.ly/M9gNmBR
November 27, 2025 at 8:29 AM
brightgiant.bsky.social
🌱 The quest to enhance long-term soil carbon storage 🌏

#SIRIUS6 #CompoundClassPrediction was essential for annotating 80% of the previously unknown metabolite features of tall wheatgrass root exudates.

💡 More #SIRIUSDiscoveries: buff.ly/HP0dTWO
📄 Publication: buff.ly/sYB1nPm
November 25, 2025 at 8:52 AM
brightgiant.bsky.social
How can we assess the risk of a compound we can't even name?
SIRIUS molecular fingerprints serve as crucial inputs for predictive models, such as #ToxicityPrediction, even when the exact identity of a compound is unknown.

📄 doi.org/10.1016/j.en...

#SIRIUSFacts #SIRIUS6 #NonTargetAnalysis
November 20, 2025 at 8:29 AM
brightgiant.bsky.social
#SIRIUS6 in a #NonTargetedAnalysis to identify unknown chemical compounds with potential estrogenic activity to investigate the link between #DrinkingWater #contaminants and #BreastCancer incidence.

▶️ Try SIRIUS now: buff.ly/K8wQ3ER
💡 Original publication: buff.ly/SZ2LPbp

#SmallMoleculeID
November 13, 2025 at 8:29 AM
brightgiant.bsky.social
Untargeted #metabolomics using #SIRIUS6 is mapping the #InternationalSpaceStation
Most extensive look yet at the microbial and chemical landscape of the ISS.

💡 Blog post: buff.ly/nGt934u (5 min)
📄 Original publication: buff.ly/s8BBclb
▶️ Try #SIRIUS6 now: buff.ly/K8wQ3ER

#SIRIUSDiscoveries
November 11, 2025 at 8:52 AM
brightgiant.bsky.social
#SIRIUS6 compound class prediction helps to validate ethanol extraction for human faecal #metabolomics as a valid, safer, and more economical alternative to the common methanol extraction.

▶️ Try SIRIUS now: buff.ly/x7dNWAR
📄 Publication: buff.ly/cGkUOyi

#SIRIUSDiscoveries #Microbiome
November 6, 2025 at 8:48 AM
brightgiant.bsky.social
New study from the long-running @jena-experiment.bsky.social challenges core ecological assumption: that in a diverse ecosystem, plants can save energy on defenses and focus on growth.
📄 Blog feature: buff.ly/LgCEGpL
📄 Publication: buff.ly/u6lzwUe

#SIRIUS6 #SIRIUSDiscoveries #NonTargetedAnalysis
November 4, 2025 at 8:48 AM
brightgiant.bsky.social
#MultiOmics study revelead link between microbial community structure and chemical profile of the surface #metabolome in Saccharina latissima.

💡 Check out more SIRIUS discoveries: buff.ly/aI5m3ps
📄 Paper: buff.ly/uUT34E0

#SIRIUSDiscoveries #MarineBiology #Microbiology #ChemicalEcology
October 30, 2025 at 8:48 AM
brightgiant.bsky.social
Green solvents can effectively extract diverse bioactive compounds from Melissa officinalis leaves. SIRIUS was employed for the comprehensive annotation of metabolites, resulting in the putative annotation of 444 metabolites.

💡 More #SIRIUSDiscoveries: buff.ly/aI5m3ps
📄 Paper: buff.ly/AEpoIFv
October 28, 2025 at 8:52 AM
brightgiant.bsky.social
In this #NonTargetedAnalysis utilizing SIRIUS, researcher successfully identify common and previously unreported chemical contaminants in human milk, including novel parabens.

Blog post: buff.ly/0vQizvG
Paper: buff.ly/Mg8axQF

#SIRIUS6 #StructureElucidation
October 22, 2025 at 7:48 AM
brightgiant.bsky.social
Using SIRIUS, researcher identified anti-viral compounds in Caesalpinia mimosoides hydroethanolic extract that help to inhibit influenza A virus by targeting two critical viral proteins.

▶️ Try SIRIUS: buff.ly/x7dNWAR
💡 More SIRIUS discoveries: buff.ly/aI5m3ps
📄 Original publication: buff.ly/qR8zEvb
October 15, 2025 at 7:48 AM
brightgiant.bsky.social
New review on #MassSpectrometry-based #Metabolomics for #NaturalProductResearch positions #SIRIUS6 as the leading suite for molecular structure annotation.

▶️ Try SIRIUS now: buff.ly/x7dNWAR
📄 Read the full review: buff.ly/0mMyixO

#StructureElucidation #SmallMoleculeID #MachineLearning
October 8, 2025 at 7:48 AM
brightgiant.bsky.social
MCheM integrates online chemical labeling reactions directly into the LC-MS/MS workflow to provide structural information which is fed into #SIRIUS6 via @mzmine.bsky.social to significantly constrain the molecular structure search space and boost annotation accuracy.

Learn more: buff.ly/iib0L6I
October 1, 2025 at 7:48 AM
brightgiant.bsky.social
🧠 ✏️ Your chemical intuition, now integrated into #SIRIUS6.
Have you tried the new Structure Sketcher yet?
▶️ Watch our new YouTube tutorial to learn how to use the Structure Sketcher and elevate your annotation process: www.youtube.com/watch?v=_byB...

#HowToSIRIUS #SmallMoleculeID #MassSpec
September 24, 2025 at 7:23 AM
brightgiant.bsky.social
🌍✨We're blown away by the growth of the SIRIUS community!

We're seeing unprecedented usage and impact of our software across the globe.

⬆️ 1.000.000.000+ processed queries
👥 1.500+ monthly active users

🙏 Thank you for being part of this journey. We're excited to see what you discover next!
September 3, 2025 at 7:48 AM
brightgiant.bsky.social
⚠️ Important Announcement for SIRIUS 5 Users! ⚠️
Maintenance and support for SIRIUS 5 will officially end on 🗓️ February 28, 2026.

To ensure you continue to benefit from the latest advancements, we highly recommend upgrading to #SIRIUS6: buff.ly/91GQKjH

#SIRIUSSoftware #SmallMoleculeAnnotation
August 27, 2025 at 7:48 AM
brightgiant.bsky.social
🚀 SIRIUS v6.3 is here!
We're excited to introduce the latest version of #SIRIUS with powerful new features to enhance small molecule identification.

⬇️ Learn more and download SIRIUS v6.3 today:
bright-giant.com/sirius-relea...

#SIRIUS6 #MSsoftware #MassSpectrometry #SmallMoleculeIdentID
August 20, 2025 at 7:48 AM
brightgiant.bsky.social
Test your #SIRIUS6 knowledge! 🧠

❓ The SIRIUS software uses an ILP solver to perform which specific task ❓
Drop a comment with your answer! The correct answer will be revealed on Friday.

Learn more about #SIRIUSSoftware: buff.ly/vBOiq3F

#SmallMoleculeID #StructureElucidation
August 18, 2025 at 7:28 AM
brightgiant.bsky.social
Times Are Changing, but Order Matters: The @boeckerlab.bsky.social has introduced a groundbreaking two-step method for transferable retention time prediction
buff.ly/vcFreLJ

#Chromatography #RetentionTime #MachineLearning #SmallMoleculeIdentification
August 14, 2025 at 9:55 AM
brightgiant.bsky.social
SIRIUS identifies potentially allergenic transformation products of tattoo pigments in new online-LC-EC-MS approach that overcomes the challenge of impure pigment standards by separating pigments from impurities before simulating their metabolism. #SmallMoleculeID #SIRIUS6 doi.org/10.1007/s002...
July 30, 2025 at 7:48 AM
brightgiant.bsky.social
🚨 Detecting deadly nitazenes just got easier. A new study uses untargeted LC-HRMS + #SIRIUS6 to ID key phase I/II metabolites, boosting opioid detection. Advanced #MSsoftware + #MachineLearning are shaping the future of #Toxicology. #DrugDiscovery #SIRIUSDiscoveries doi.org/10.3390/meta...
July 23, 2025 at 7:48 AM
brightgiant.bsky.social
🪸 New study reveals coral resilience may be inherited! Using LC-MS/MS + #SIRIUS, scientists found thermal tolerance compounds passed from parent to offspring in Montipora capitata. Biochemical “memory” could guide reef restoration in a warming world. 🪸 #CoralReef #Science

doi.org/10.1038/s414...
July 17, 2025 at 9:09 AM