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Bryce Manso, Ph.D. @brycemanso.bsky.social · 7d

We have packed a ton into this paper, so please enjoy and reach out with any questions!
A HUGE thank you to all the collaborators and funding sources for making this happen!

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Bryce Manso, Ph.D. @brycemanso.bsky.social · 7d

We also demonstrate that both intrinsic and extrinsic effects contribute to informating HSCs to take this pathway, and that MkPs generated via this path uniquely possess a survival advantage!

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Bryce Manso, Ph.D. @brycemanso.bsky.social · 7d

Here, we add to and clarify a number of new findings in the world of #megakaryopoiesis at steady-state and during aging, including officially revealing the ability to identify HSC-direct, age-dependent MkPs without the need of a lineage tracing model!

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Bryce Manso, Ph.D. @brycemanso.bsky.social · 7d

A little late, but 🚨new paper alert!🚨
Interested in #aging, #blood, #StemCells, #HSCs, #platelets, or #MkPs? Read on!
onlinelibrary.wiley.com/doi/10.1111/...

A Rare Hematopoietic Stem Cell‐Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging

Manso et al. developed strategies for isolating and testing the functional mechanisms regulating age-specific megakaryocyte progenitors derived from hematopoietic stem cells.

onlinelibrary.wiley.com

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Reposted by Bryce Manso, Ph.D.

Kara Swisher @karaswisher.bsky.social · Aug 29

No notes

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Bryce Manso, Ph.D. @brycemanso.bsky.social · May 11

Bribery in 'plane' sight?
Jokes aside...this is disgusting

Brian Tyler Cohen @briantylercohen.bsky.social · May 11

Bribery in plain sight.

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Bryce Manso, Ph.D. @brycemanso.bsky.social · May 6

Hey #hematopoiesis / #StemCell / #Immunology / #Laboratory people (any field!) Looking for an exceptionally talented and dedicated junior specialist/associate/technician? Have I got the person for you!! They are open to moving anywhere in the US or internationally! DM for details/contact. Please RT!

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Reposted by Bryce Manso, Ph.D.

Randall Munroe @xkcd.com · Apr 25

PhD Timeline xkcd.com/3081

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Bryce Manso, Ph.D. @brycemanso.bsky.social · Mar 27

For an act to be evil, does it have to be intentional? Or can (willful?) ignorance that results in a harmful act still be considered evil?
Asking for a friend (the US is the friend) #iykyk

Bryce Manso, Ph.D. @brycemanso.bsky.social · Mar 27

So, spam/predatory/scam messages for papers, conferences, speaking engagements, etc. are pretty common, but today I finally got the one I've always wanted! The good 'ol 'Dear Dr. FirstName'

Reposted by Bryce Manso, Ph.D.

Denis Wirtz @deniswirtz.bsky.social · Mar 9

As federal funding for research is uncertain, we need to diversify funding sources for our PhD students.

Here is a comprehensive list of >160 PhD fellowships and funding opportunities, mostly from private foundations and scientific societies.

Download it here: research.jhu.edu/rdt/funding-...

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Bryce Manso, Ph.D. @brycemanso.bsky.social · Mar 7

Can't attend any Stand Up for Science (@standupforscience.bsky.social) events today due to family obligations, but my heart, soul, and passion is with you all! #Science is a major cornerstone of our global, national, and local communities. Rally the masses and be seen, heard, and not ignored!

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Reposted by Bryce Manso, Ph.D.

Sem (they/them) @16161d.bsky.social · Mar 2

this might help:

bsky.app/profile/prof...

Stefan Marciniak @profmarciniak.bsky.social · Mar 2

#Pubmed problem fix?

Resetting DNS to Cloudfare 1.1.1.1 worked

I could use Pubmed on phone but not computer, but fixed Mac by:

settings > network > details > DNS > press “+” and type 1.1.1.1

🎉

Stefan Marciniak @profmarciniak.bsky.social · Mar 2

#Pubmed problems being reported

Please say if it’s working for you, your country and search engine

(perhaps retweet for larger sample size

🤷‍♂️ fine for me, UK & Safari

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Bryce Manso, Ph.D. @brycemanso.bsky.social · Mar 2

Woke up to an email from the #NIH saying that my K22 Summary Statement was available! Super exciting! To my dismay, the NIH websites (nearly ALL of them) have been down all day. Not normal. Others see the same, with no reason given. Hopefully nothing important, but given everything...not too hopeful

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Reposted by Bryce Manso, Ph.D.

Tina Termini @cterminiphd.bsky.social · Feb 25

The Termini Lab at Fred Hutch in Seattle is recruiting a Lab Aide to join our group - more information and instructions to apply can be found at the posting below 👇🧫👇🔬👇🐁
careers-fhcrc.icims.com/jobs/29265/l...

Fred Hutchinson Cancer Center

Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

careers-fhcrc.icims.com

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Reposted by Bryce Manso, Ph.D.

MwahahahahahadScientist @mads100tist.bsky.social · Feb 11

PSA: 10X will discontinue the GEM Kits (3', 5' and Flex) at the end of the year, in case you want to get one in storage for paper revisions

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Bryce Manso, Ph.D. @brycemanso.bsky.social · Feb 1

Hostelling*

Bryce Manso, Ph.D. @brycemanso.bsky.social · Feb 1

While the US Federal government continues their heinous attacks against DEI, I am so happy to be staying at a Hosteling International property!

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Bryce Manso, Ph.D. @brycemanso.bsky.social · Jan 2

This is such a cool idea! Consider myself volunteered!

Skype a Scientist @skypeascientist.bsky.social · Dec 30

Scientists!

We are trying to get 1000 of us into the volunteer database by Jan 1.

You'll be volunteering to speak with classrooms over video chat about your work, and answer their questions! You can volunteer for up to 5 sessions per semester.

Sign up here! www.skypeascientist.com/sign-up.html

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Reposted by Bryce Manso, Ph.D.

Mueller, She Wrote @muellershewrote.com · Dec 25

I’m with Denmark.

Jon Cooper @joncooper-us.bsky.social · Dec 25

I love how Denmark isn’t taking any shit from Donald Trump. 🇩🇰 🤣

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Reposted by Bryce Manso, Ph.D.

Native Santa Cruz @nativesantacruz.bsky.social · Dec 15

Tornadoes in California? In Santa Cruz County? Yep, Scott’s Valley got hit relatively hard with a few injuries

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Bryce Manso, Ph.D. @brycemanso.bsky.social · Dec 13

Full link to the text:
www.biorxiv.org/content/10.1...

A rare HSC-derived megakaryocyte progenitor accumulates via enhanced survival and contributes to exacerbated thrombopoiesis upon aging

Distinct routes of cellular production from hematopoietic stem cells (HSCs) have defined our current view of hematopoiesis. Recently, we challenged classical views of platelet generation, demonstratin...

www.biorxiv.org

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Bryce Manso, Ph.D. @brycemanso.bsky.social · Dec 6

As if my #ASH24 FOMO wasn't enough already, they go and do this!

Ruben A. Mesa, MD, FACP @rubenmesamd.bsky.social · Dec 6

Pickleball at #ASH24! Setting a new standard for fun at meetings. Well done @ash-hematology.bsky.social (#ASCO will be jealous)

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Reposted by Bryce Manso, Ph.D.

Grant Rowe @bloodandtime.bsky.social · Dec 5

Just in time for #ASH24, our latest paper is out. We performed scRNA-seq on HSPCs over human development, maturation, and postnatal aging. We looked at dynamics of HSPC subsets, lineage biases, HSC level priming, and identified a developmentally restricted human HSC.
www.nature.com/articles/s41...

The dynamics of hematopoiesis over the human lifespan - Nature Methods

This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.

www.nature.com

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Bryce Manso, Ph.D. @brycemanso.bsky.social · Dec 4

(7/7)...Finally, environment may be the "missing link" to this age-unique pathway, but more on that soon......
Please do give it a read and let us know what you think! We are excited to share this story!

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