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Grant Rowe @bloodandtime.bsky.social · 28d

There are two types of people in academic medicine - those who are there because it is their lifetime calling, others who are there to take home a paycheck.
The fundamental problem is that those there for the paycheck hold all of the power.

Reposted by Grant Rowe

Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · Sep 10

The ISEH just launched a brand new website! Check it out and join our society today to network with your colleagues and keep abreast of the latest advances in basic and translational experimental hematology research!

iseh.org

Home

iseh.org

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Grant Rowe @bloodandtime.bsky.social · Aug 12

I really enjoyed reading this paper. Use of basic culture-based and in vivo differentiation models with targeted application of -omics.

Blood Journals' Portfolio @bloodjournals.hematology.org · Aug 11

Cell cycle shortening precedes the restriction of lymphoid and myeloid potentials. buff.ly/a3DeNsO #hemesky

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Grant Rowe @bloodandtime.bsky.social · Jun 30

Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology
@isehsociety.bsky.social
www.exphem.org/article/S030...

Remembering James Till, 1931-2025

It has been 64 years since the publication of the classic 1961 Till & McCulloch paper that described spleen colonies in lethally irradiated mice following a bone marrow transplant [1]. On May 18, 2024...

www.exphem.org

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Grant Rowe @bloodandtime.bsky.social · May 27

Here is the first in a planned series of article commentaries in Experimental Hematology
@isehsociety.bsky.social - thanks to @challenlab.bsky.social and @lindemileslab.bsky.social!
www.exphem.org/article/S030...

Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis

Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...

www.exphem.org

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Reposted by Grant Rowe

Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · Feb 28

What an interesting read...did you know that Developmental Hematopoiesis pioneer Elaine Dzierzak was also an artist? Read on to learn more in a recent issue of Experimental Hematology!

The developmental clock: where art and science meet - Experimental Hematology www.exphem.org/article/S030...

The developmental clock: where art and science meet

Elaine DzierzakDrs. Elaine Dzierzak and Anna Bigas recently edited a special collection for Experimental Hematology entitled “Making blood: mechanisms of early hematopoietic development” [1]. This is ...

www.exphem.org

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Reposted by Grant Rowe

Alessandro Donada @alessandrodonada.bsky.social · Feb 27

Absolute pleasure to chat with those two brilliant scientists! Do yourself a favour and have a look at their preprints! #hemesky

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Feb 25

@alessandrodonada.bsky.social sat down with @dpastoors.bsky.social and @tjflemin.bsky.social for a deep dive on their latest AML biology preprints. Watch the #SimplyBlood 🩸 interview today https://www.simplyblood.org/

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Grant Rowe @bloodandtime.bsky.social · Feb 21

I failed a billing audit this week and it was like I had left the new coversheets off of my TPS reports #medicaladministrativestate

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Grant Rowe @bloodandtime.bsky.social · Feb 19

We are very proud of this new content spearheaded by @alessandrodonada.bsky.social!
Our lab is very grateful to Alessandro for highlighting our two recent preprints.

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Feb 18

This month's #PreprintWatch covers some exciting new results on the impact of microenvironment on hematopoietic progenitors and novel approaches to long-standing questions like self-renewal and stem cell activity! Read now on https://www.simplyblood.org/

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Reposted by Grant Rowe

Mick Milsom @milsommick.bsky.social · Feb 6

@isehsociety.bsky.social community: if you’re interested in HSC research in humans then this is a must read from leaders in the field. www.exphem.org/article/S030...

Methodological Considerations on How to Identify Human Hematopoietic Stem Cells

The hematopoietic system is highly regenerative and is organized hierarchically with hematopoietic stem cells (HSCs) sitting at the apex. Despite being some of the most widely studied stem cells, ques...

www.exphem.org

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Reposted by Grant Rowe

bioRxivpreprint @biorxivpreprint.bsky.social · Jan 30

Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL https://www.biorxiv.org/content/10.1101/2025.01.27.635108v1

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Grant Rowe @bloodandtime.bsky.social · Jan 25

Second preprint of the day:
www.biorxiv.org/content/10.1...

Path of differentiation defines human macrophage identity

Macrophages play central roles in immunity, wound healing, and homeostasis - a functional diversity that is underpinned by varying developmental origins. The impact of ontogeny on properties of human ...

www.biorxiv.org

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Reposted by Grant Rowe

ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Jan 24

Look at that, a trifecta of ISEH member preprints @bloodandtime.bsky.social @dorrancelab.bsky.social @kentlab.bsky.social
biorxiv.org/content/earl...
biorxiv.org/content/earl...
biorxiv.org/content/earl...

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Grant Rowe @bloodandtime.bsky.social · Jan 24

Here's a new preprint from our group. This manuscript continues our efforts to understand the mechanisms that distinguish fetal/juvenile versus adult hematopoiesis to better understand pediatric blood diseases.
www.biorxiv.org/content/10.1...

Dynamic activity of Erg promotes aging of the hematopoietic system

Hematopoiesis changes to adapt to the physiology of development and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of blood diseases. Several heterochronic regulators of he...

www.biorxiv.org

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Grant Rowe @bloodandtime.bsky.social · Jan 17

Early morning swimming in the cold at Stanford.

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Reposted by Grant Rowe

Alessandro Donada @alessandrodonada.bsky.social · Jan 10

I really enjoy putting those together, please if you see your preprint in this list do not hesitate to get in touch!
#hemesky 🔬🩸

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Jan 9

The first Preprint Watch for 2025 is plentiful: 9 preprints focusing on Acute Myeloid Leukemia, but also spatial fate mapping meets barcoding, how cell fate decisions occur in hematopoietic progenitors, and more! Read now➡️ simplyblood.org

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Grant Rowe @bloodandtime.bsky.social · Jan 3

answers.childrenshospital.org/blood-atlas/

Blood across our lifetimes: A dynamic story - Boston Children's Answers

A new atlas reveals how blood stem cells ramp up and pivot their activities to match our needs across our lifespan.

answers.childrenshospital.org

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Reposted by Grant Rowe

Kate MacNamara @macnamaralab.bsky.social · Dec 27

Winter break is good for catching up on some reading 😉! #ISEH #SimplyBlood @isehsociety.bsky.social

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Dec 20

This week on Simply Blood, we're highlighting selected articles on HSC metabolism in Experimental Hematology. Read curated articles on this topic and explore new findings ➡️ www.simplyblood.org

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Grant Rowe @bloodandtime.bsky.social · Dec 27

Interesting mechanistic work on reticular dysgenesis from my former colleague Dr Weinacht @bloodjournal.bsky.social
ashpublications.org/blood/articl...

Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis

Key PointsActive metabolic checkpoints respond to AK2 deficiency by decreasing anabolic pathways to maintain nutrient homeostasis and proliferation.When me

ashpublications.org

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Reposted by Grant Rowe

Peter van Galen @vangalenlab.bsky.social · Dec 23

Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...

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Grant Rowe @bloodandtime.bsky.social · Dec 20

speedball.

Grant Rowe @bloodandtime.bsky.social · Dec 18

Thanks, friend. Hope you are well.

Grant Rowe @bloodandtime.bsky.social · Dec 18

We are very proud of this new resource for the community. Thanks @alessandrodonada.bsky.social for leading this initiative!

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Dec 17

Traveling for the holidays? Take this time to read the last #PreprintWatch installment of 2024! This month on #SimplyBlood🩸 we're featuring 17 preprints, including a new community submission ➡️ www.simplyblood.org

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Grant Rowe @bloodandtime.bsky.social · Dec 18

I am very proud to direct the Bone Marrow Failure Clinic at Dana-Farber/Boston Children's.
answers.childrenshospital.org/sadie-aplast...

A small act of kindness: Blood donations get Sadie off the sidelines after her aplastic anemia diagnosis - Boston Children's Answers Sadie thrives with aplastic anemia

Sadie was sidelined by aplastic anemia. Now she's back in the game, thanks to life-saving blood transfusions and expert care.

answers.childrenshospital.org

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Grant Rowe @bloodandtime.bsky.social · Dec 16

based.