Burkard Lab
@burkardlab.bsky.social
94 followers 220 following 12 posts
Burkard Lab | Holden Comprehensive Cancer Center | University of Iowa Studying chromosomal instability, mitotic regulation & cancer evolution Directed by Dr. Mark E. Burkard
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burkardlab.bsky.social
👋 Welcome to the Burkard Lab!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
Reposted by Burkard Lab
burkardlab.bsky.social
We’re excited to share a Postdoc Opening in the Burkard Lab @iowa /Holden Cancer Center. The fellow will study mitotic regulation in normal & cancer cells, exploring drug response & resistance in human samples, organoids, & preclinical models. Spread the word!
📅 Apply by 3/1/26
📧 [email protected]
Postdoc Opportunities
Open postdoc positions are listed in the interactive table below. The table is best viewed in landscape mode if on a mobile device. Use the search box to narrow your search. Click on the column header...
pob.wisc.edu
Reposted by Burkard Lab
burkardlab.bsky.social
Want better resolution of small chromatin / subnuclear structures? Our new method, One-step 4× and 12× 3D-ExM, improves super-resolution microscopy in both 2D and 3D cell culture. Useful for labs studying kinetochores, nuclear pores, chromosomes, etc. #methods #microscopy #cellbiology
One step 4× and 12× 3D-ExM enables robust super-resolution microscopy of nanoscale cellular structures | Journal of Cell Biology | Rockefeller University Press
The 4× and 12× 3D-ExM methods were optimized for super-resolution expansion microscopy, offering a one-step expansion process without the need for speciali
rupress.org
Reposted by Burkard Lab
burkardlab.bsky.social
Chromosomal instability is everywhere in cancer biology—but how do we actually measure it?
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology
The reckoning of chromosomal instability: past, present, future - Chromosome Research
Quantitative measures of CIN are crucial to our understanding of its role in cancer. Technological advances have changed the way CIN is quantified, offering increased accuracy and insight. Here, we re...
link.springer.com
Reposted by Burkard Lab
burkardlab.bsky.social
Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
Reposted by Burkard Lab
burkardlab.bsky.social
👋 Welcome to the Burkard Lab!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
burkardlab.bsky.social
We’re excited to share a Postdoc Opening in the Burkard Lab @iowa /Holden Cancer Center. The fellow will study mitotic regulation in normal & cancer cells, exploring drug response & resistance in human samples, organoids, & preclinical models. Spread the word!
📅 Apply by 3/1/26
📧 [email protected]
Postdoc Opportunities
Open postdoc positions are listed in the interactive table below. The table is best viewed in landscape mode if on a mobile device. Use the search box to narrow your search. Click on the column header...
pob.wisc.edu
burkardlab.bsky.social
Thank you! Would you please add us to the list too?
burkardlab.bsky.social
Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
burkardlab.bsky.social
Chromosomal instability is everywhere in cancer biology—but how do we actually measure it?
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology
The reckoning of chromosomal instability: past, present, future - Chromosome Research
Quantitative measures of CIN are crucial to our understanding of its role in cancer. Technological advances have changed the way CIN is quantified, offering increased accuracy and insight. Here, we re...
link.springer.com
burkardlab.bsky.social
Want better resolution of small chromatin / subnuclear structures? Our new method, One-step 4× and 12× 3D-ExM, improves super-resolution microscopy in both 2D and 3D cell culture. Useful for labs studying kinetochores, nuclear pores, chromosomes, etc. #methods #microscopy #cellbiology
One step 4× and 12× 3D-ExM enables robust super-resolution microscopy of nanoscale cellular structures | Journal of Cell Biology | Rockefeller University Press
The 4× and 12× 3D-ExM methods were optimized for super-resolution expansion microscopy, offering a one-step expansion process without the need for speciali
rupress.org
burkardlab.bsky.social
Thank you Adrian for leading this, would you add our lab to the pack as well. Appreciate it.
burkardlab.bsky.social
Thank you for creating and leading this pack! We would like to join. :)
burkardlab.bsky.social
Hi! We would like to join the Cancer Bio Starter pack . Thank you for leading and creating this!
burkardlab.bsky.social
👋 Welcome to the Burkard Lab!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
burkardlab.bsky.social
Dear Andre, would you please add our lab to your starter pack? Much appreciated.
burkardlab.bsky.social
Dear Adrian, would you please add our lab to your Aneuploidy and Chromosomal Instability and Cell Cycle and Senescence starter list? Much appreciated it!