Christoph Handschin
@c-handschin.bsky.social
310 followers 110 following 50 posts
Researcher @biozentrum.bsky.social of @unibasel.bsky.social in 🇨🇭. Skeletal #muscle plasticity / #exercise / #neuromuscular diseases / #aging / #metabolism / #PGC-1alpha https://biozentrum.unibas.ch/handschin
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c-handschin.bsky.social
Hi Monica,

could you add me to Science feed please? Thanks!

Google Scholar: scholar.google.com/citations?us...
scholar.google.com
Reposted by Christoph Handschin
biozentrum.unibas.ch
Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibas.ch #fellowship #PhD#Switzerland
Biozentrum PhD Fellowships
Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...
bit.ly
Reposted by Christoph Handschin
rbreich.bsky.social
The first time Charlie Chaplin used his voice in a film, he wielded it to forcefully condemn the rising forces of fascism around the globe.

Will we listen to his words today?
Reposted by Christoph Handschin
apsphysiology.bsky.social
In today's read from Function, APS CEO Scott Steen explains where we, and #physiology, go from here during this time "of unprecedented challenge for science in the United States." ow.ly/zTTT50Wj8bz #WeArePhysiology 🧪 @apspublications.bsky.social
A female scientist in a lab coat is using a microscope to examine a sample.
c-handschin.bsky.social
"Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response" - our new manuscript describes the changes in chromatin accessibility in exercise (acute & training) associated with gene expression.
www.sciencedirect.com/science/arti...
Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response
Endurance training is known to elicit numerous changes in skeletal muscle to enhance performance and function. Many of these adaptations are controlle…
www.sciencedirect.com
Reposted by Christoph Handschin
apspublications.bsky.social
#OpenAccess: Review from Physiological Reviews, Biomarkers of #aging: from molecules and surrogates to physiology and function

Regula Furrer and Christoph Handschin
🖱️doi.org/10.1152/phys...
#exercise #healthspan #longevity @unibas.ch
c-handschin.bsky.social
This just in from @apsphysiology.bsky.social
"Early reports indicate that the Trump administration’s proposed FY 2026 budget would slash funding for the NIH by more than 40%, cutting the budget from $47 billion to $27 billion. The APS urges Congress to reject this catastrophic proposal..."
c-handschin.bsky.social
Now out in the typeset, final version! #openaccess

"Biomarkers of aging: from molecules and surrogates to physiology and function"

@apspublications.bsky.social @apsphysiology.bsky.social @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch

doi.org/10.1152/phys...
Biomarkers of aging: from molecules and surrogates to physiology and function | Physiological Reviews | American Physiological Society
Many countries face an unprecedented challenge in aging demographics. This has led to an exponential growth in research on aging, which, coupled to a massive financial influx of funding in the private and public sectors, has resulted in seminal insights into the underpinnings of this biological process. However, critical validation in humans has been hampered by the limited translatability of results obtained in model organisms, additionally confined by the need for extremely time-consuming clinical studies in the ostensible absence of robust biomarkers that would allow monitoring in shorter time frames. In the future, molecular parameters might hold great promise in this regard. In contrast, biomarkers centered on function, resilience, and frailty are available at the present time, with proven predictive value for morbidity and mortality. In this review, the current knowledge of molecular and physiological aspects of human aging, potential antiaging strategies, and the basis, evidence, and potential application of physiological biomarkers in human aging are discussed.
doi.org
c-handschin.bsky.social
"This moment calls out for moral clarity and resolve. It asks universities to take their mission in society seriously and to resist being co-opted by government forces."
@arstechnica.com
arstechnica.com/culture/2025...
Resist, eggheads! Universities are not as weak as they have chosen to be.
Opinion: It’s time for public resistance.
arstechnica.com
c-handschin.bsky.social
What the is early stress response in exercised #muscle for? At least for Klf5, this seems important to shape lipid homeostasis in the acute (fatty acid metabolism) and chronic (lipid synthesis) settings. All this and more in our new paper:

#myoblue

www.sciencedirect.com/science/arti...
Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle
Regular physical activity induces a variety of health benefits, preventing and counteracting diseases caused by a sedentary lifestyle. However, the mo…
www.sciencedirect.com
c-handschin.bsky.social
8.) Our current health care setting fails to prioritize such measures. What could be done to improve the situation? On the level of the individual person, health care professionals, health insurance providers, society and politics. How could we pay for this?

8/9
Changes that could improve healthy aging.
c-handschin.bsky.social
7.) In contrast for physiological, functional and anthropometric biomarkers, solid and broad human data exist! E.g. #VO2max, body composition (muscle and #fat mass/distribution), #muscle force and power, activity levels, gait speed and other frailty markers.

7/9
Various biomarkers of aging, with different degrees of clinical evidence.
c-handschin.bsky.social
6.) How measure aging trajectories or "biological age"? Current state of molecular #biomarkers, e.g. #epigenetic marks, plasma proteomics or #telomere length.

6/9
Molecular "clocks" and biomarkers of aging.
c-handschin.bsky.social
5.) What does work? Interventions with solid data on human aging, #morbidity, #mortality and/or #longevity: physical activity, #sleep, #nutrition, #stress, social interactions, socioeconomic disparities, #climatechange and much more!

5/9
Modifiers of healthy aging with solid and broad data in humans.
c-handschin.bsky.social
4.) Proposed "#anti-aging drugs" and interventions in human aging, e.g. #rapamycin, #metformin, #resveratrol, but also #reprogramming, #rejuvenation, #caloric restriction. Potentially negative effects on other health-beneficial interventions (e.g. #exercise).

4/9
Molecular and cellular hallmarks of aging, and the proposed drugs and interventions that could modify these.
c-handschin.bsky.social
2.) How to study aging? E.g. Genetic diseases of "accelerated aging" (e.g. #progeria), (super-) #centenarians and geography (e.g. in a so-called #BlueZone).

3.) How might human aging differ from that in animals? What could this mean for the study of model organisms in this field?

3/9
Old (left side) and young (right side) mouse.