Caitlyn Fastenau, PhD
@caitlynfastenau.bsky.social
64 followers 48 following 100 posts
PhD Integrated Biomedical Sciences | Clinical Trial Post-Doctoral Fellow @buckinstitute.org‬ | Alzheimer's Association A&D Journal Family Social Media Editor | 2024-2025 Alzheimer's Association ‪ISTAART Ambassador | Science Communicator
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caitlynfastenau.bsky.social
📢NEW PAPER: Where is sugar in the brain?📢

Sugar in the brain? More like sialylation, a post-translational or sugar modification in AD brains. Check out this 🧵to learn all about PTMs, histology, and translational science in my latest publication!

Article: onlinelibrary.wiley.com/doi/10.1111/...
caitlynfastenau.bsky.social
Research on Modifiable Risk Factors for AD research is CRITICAL! Check out this thread for research publications on interesting risk factors!

We can all learn something new in the fight against ADRD! #AlzSky
alzdemjournals.bsky.social
What lifestyle and biological factors impact the development of AD & related dementias?

Research published in A&D journal family highlights critical modifiable risk factors, check out this 🧵on recent publications
#AlzSky
caitlynfastenau.bsky.social
Check out this conference on Unconventional Animal Models in AD and Aging! This conference is hosted by @ucirvine.bsky.social and @alzdemjournals.bsky.social guest editors! #UAMAA2026

In science, it is critical to have multiple model systems to investigate complex questions🐭🪱🪰🐀
alzdemjournals.bsky.social
Interested in unique models for ADRD?

Check out the Unconventional Animal Models
of Alzheimer’s Disease and Aging
(UAMAA) Conference coming up in 2026! Hosted by A&D guest editors and @ucirvine.bsky.social

Conference Details: cncm.medschool.uci.edu/uamaa-2026/

#UAMAA2026
UAMAA 2026 – UC Irvine Center for Neural Circuit Mapping
cncm.medschool.uci.edu
caitlynfastenau.bsky.social
Interested in our other outstanding work on sialylation? Check out my other first-authored publications

🐁
pubmed.ncbi.nlm.nih.gov/36867284/

🧠
onlinelibrary.wiley.com/doi/full/10....
caitlynfastenau.bsky.social
This work was supported by my amazing PhD mentors @hoppzor.bsky.social and Dr. Kevin Bieniek, @uthealthsa.bsky.social and all co-authors👏

Check out our publication now! #ADRD
caitlynfastenau.bsky.social
Comparing across AD+CAA cases, there were less differences between sialylation levels in the space surrounding arterioles or the peri-vascular space. Further supporting CAA-driven increase in intra-vascular sialylation!
caitlynfastenau.bsky.social
Histologically, we determined AD+CAA brains have increased sialylation intravascularly compared to “pure AD” brains. Potentially suggesting the intersection of this PTM and vessel vulnerability🧠
caitlynfastenau.bsky.social
We focused on sialylation location in AD brains with Cerebral Amyloid Angiopathy (CAA)🩸. The increasing prevalence of ARIA events related to anti-amyloid therapies makes this work vitally important. We found significant differences in sialylation location between “pure AD” and AD+CAA!
caitlynfastenau.bsky.social
📢NEW PAPER: Where is sugar in the brain?📢

Sugar in the brain? More like sialylation, a post-translational or sugar modification in AD brains. Check out this 🧵to learn all about PTMs, histology, and translational science in my latest publication!

Article: onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Caitlyn Fastenau, PhD
Reposted by Caitlyn Fastenau, PhD
caitlynfastenau.bsky.social
👏TRIALS THAT ARE FEASIBLE AT HOME!

Check out this research published in #BSEA!
alzdemjournals.bsky.social
How are lifestyle interventions investigated?

New research in #BSEA outlines feasibility of the REMINDer trial, a 6-week online, home-based, multimodal group intervention delivered via videoconferencing. #AlzResearch

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
caitlynfastenau.bsky.social
Infection and ADRD?? Heck yes!

Such an important topic!🧠

Submit your research to #TRCI!
Reposted by Caitlyn Fastenau, PhD
alzdemjournals.bsky.social
Research in #DADM found cognition in young adult men was associated with ⬆️ leisure-time activity &⬇️work-related activity in midlife, suggesting a window of opportunity for prevention in early life #AlzSky

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
caitlynfastenau.bsky.social
Check out this new research in #TRCI!

Don't miss out on critical research on representative populations! #AlzSky
alzdemjournals.bsky.social
Globalizing ancestral diversity in AD genetics is essential to identify interventions across populations. Learn about critical efforts to address this need in this #TRCI article🧵

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Caitlyn Fastenau, PhD
alzdemjournals.bsky.social
A&D Call for Papers: Alzheimer's & Dementia Special Issue: Neuromodulatory Subcortical Systems in Alzheimer's Disease

Highlight your work on neurodegenerative disease pathogenesis in the NSS #AlzResearch

⏰Updated Deadline: Nov. 30, 2025

alz-journals.onlinelibrary.wiley.com/hub/journal/...
Alzheimer's & Dementia
Enter your email to receive alerts when new articles and issues are published.
alz-journals.onlinelibrary.wiley.com
Reposted by Caitlyn Fastenau, PhD
buckinstitute.org
Is brain/gut axis a superhighway for immune response to #Alzheimers? Study in @cellpress.bsky.social shows immune cells use that route in mouse models. Feeding animals high fiber diet reduced AD-related frailty. Congrats Dr. Winer, Dr. Makhijani, & Dr. Andersen
www.buckinstitute.org/news/the-gut...
The gut immune system is altered in mouse model of Alzheimer’s, providing a new target for therapeutics
Feeding the animals a high fiber diet reduced Alzheimer’s-related frailty including tremor.
www.buckinstitute.org
caitlynfastenau.bsky.social
This review is a great resource for decision making recommendations for dementia diagnoses!

#BSEA is addressing critical needs for ADRD researchers and clinicians! #AlzResearch
alzdemjournals.bsky.social
Recent systematic review published in A&D: Behavior & Socioeconomics of Aging summarize methodological appraisal and decision-making recommendations to assist model development and evidence-based dementia diagnosis. #BSEA #AlzResearch #AlzSky

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
caitlynfastenau.bsky.social
This highlights the POWER of community!! Check out the amazing research coming out of A&D: Behavior & Socioeconomics of Aging #BSEA #AlzResearch #AlzSky
alzdemjournals.bsky.social
How does social infrastructure impact dementia risk?

This new #BSEA article investigates the impact of social, educational and other cognitively-protective resources to county residents. #AlzResearch #AlzSky

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Caitlyn Fastenau, PhD
alzdemjournals.bsky.social
Call For Papers! Alzheimer's & Dementia Special Issue: Neuromodulatory Subcortical Systems in Alzheimer's Disease

Research on the intersection of the Neuromodulatory Subcortical Systems and AD are welcome! #AlzResearch
⏰Deadline: Aug. 30, 2025

alz-journals.onlinelibrary.wiley.com/hub/journal/...
Alzheimer's & Dementia
alz-journals.onlinelibrary.wiley.com
caitlynfastenau.bsky.social
The intersection of AD and metabolic research is so interesting! #AlzResearch

Check out this new research in #DADM!
caitlynfastenau.bsky.social
Such important topics!
alzdemjournals.bsky.social
Research in A&D: Behavior & Socioeconomics of Aging suggests sex/gender-specific preservation of brain structure in the presence of amyloid, and advocates for further investigation into vulnerabilities across racial and ethnic groups #BSEA #Alzsky
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
caitlynfastenau.bsky.social
Loneliness and Social Isolation are such important topics that impact aging adults. Very glad to see this important research published in A&D: Diagnosis, Assessment & Disease Monitoring #DADM #ALZResearch
alzdemjournals.bsky.social
How can loneliness be addressed? Recent longitudinal research on historic mobile phone use correlates with lower risk of dementia and hippocampal volume loss. #DADM #Alzsky

Article: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Caitlyn Fastenau, PhD
alzdemjournals.bsky.social
Highlights from the 2024 AAIC Advancements: Modernizing Diagnosis, out in Alzheimer’s & Dementia! This paper explores modern biomarker-based frameworks for AD/ADRD diagnosis, and strategies to ensure equitable global access to diagnosis and treatment #AlzResearch

doi.org/10.1002/alz....
Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia‐specific perspectives
The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. M...
doi.org
caitlynfastenau.bsky.social
Check out Deputy Editor @jlingler.bsky.social representing #BSEA!

Learn more about emerging research topics for publication at the A&D website!
alzdemjournals.bsky.social
Did you enjoy the A&D Journal Family Meet the Editors sessions at #AAIC25?

Explore open Calls for Papers on the A&D website to learn more about hot topic areas of research! #AlzResearch

alz-journals.onlinelibrary.wiley.com/journal/1552...