@calebmallery.bsky.social
PhD candidate in @paczkowskilab | Using biochemistry, genetics, and structural bio to understand bacterial communication
Very excited about this, really cool work! Glad I was able to contribute during my rotation with @nilesh-banavali.bsky.social
1/ Our new preprint is out on biorxiv on how antibiotics bind to bacterial 30S subunits, please repost. #ribosome #antibiotics #microsky #rnasky doi.org/10.64898/202...
How medically important antimicrobials bind to the 30S ribosomal subunit in a bacterial pathogen
Ribosomes translate the genetic code in mRNA to synthesize proteins in all living organisms. Decoding of mRNA occurs in the small subunit of the ribosome and is mediated by tRNA anticodons. Regions ne...
doi.org
December 27, 2025 at 9:22 PM
Very excited about this, really cool work! Glad I was able to contribute during my rotation with @nilesh-banavali.bsky.social
Reposted
What started out as a structure-function project for an undergraduate researcher morphed into something bigger w/ @popea.bsky.social leading the way. Check out how RhlR fine tunes its response to its autoinducer to avoid producing too much pyocyanin.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
RhlR quorum-sensing receptor ligand sensitivity regulates the differential expression of phenazine genes in Pseudomonas aeruginosa
Bacteria control individualistic and group behaviors using a form of cell-cell communication called quorum sensing. Quorum sensing relies on the production of chemical signals called autoinducers and ...
www.biorxiv.org
December 9, 2025 at 2:22 PM
What started out as a structure-function project for an undergraduate researcher morphed into something bigger w/ @popea.bsky.social leading the way. Check out how RhlR fine tunes its response to its autoinducer to avoid producing too much pyocyanin.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted
First submission of the BlueSky era. @calebmallery.bsky.social & @ksimanek.bsky.social team up to figure out why some LuxR-type receptors might need accessory proteins to regulate gene expression.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Evolution of PqsE as a Pseudomonas aeruginosa-specific regulator of LuxR-type receptors: insights from Pseudomonas and Burkholderia
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that poses a significant public health threat, particularly in healthcare settings. A key determinant of P. aeruginosa virulence is the...
www.biorxiv.org
December 10, 2024 at 4:52 PM
First submission of the BlueSky era. @calebmallery.bsky.social & @ksimanek.bsky.social team up to figure out why some LuxR-type receptors might need accessory proteins to regulate gene expression.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...