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Jeff Calhoun

@calhoujd.bsky.social

410 followers 470 following 85 posts

Research Assistant Professor with Gemma Carvill (@CarvillLab on Twitter). Focus: epilepsy genetics. Twin. Ace cat dad. Occasional writer. I am only an egg. He/him.

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Jeff Calhoun @calhoujd.bsky.social · May 25

CliPE now available in STAR Protocols: www.sciencedirect.com/science/arti...

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Reposted by Jeff Calhoun

The American Journal of Human Genetics @ajhgnews.bsky.social · 23d

📣New today!
📄Landscapes of missense variant impact for human superoxide dismutase 1
🧑‍🤝‍🧑 @axakova.bsky.social @fritzroth.bsky.social & co

Landscapes of missense variant impact for human superoxide dismutase 1

SOD1 variants cause the motor neuron disease amyotrophic lateral sclerosis. Axakova et al. functionally assay ∼86% of all possible SOD1 missense variants, producing a variant-effect map resource that ...

www.cell.com

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Reposted by Jeff Calhoun

Ryan Estrada @ryanestrada.com · Sep 6

Just a reminder to check for your name in this list of books that OpenAI trained from. If your name is there, they probably owe you several thousand dollars.

OpenAI cried that if everyone eligible author files, the company will go bankrupt, so I'm alerting every author I have ever spoken to.

Search LibGen, the Pirated-Books Database That Meta Used to Train AI

Millions of books and scientific papers are captured in the collection’s current iteration.

www.theatlantic.com

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Reposted by Jeff Calhoun

PAX @officialpax.bsky.social · Aug 26

#PAXWest 2025 is a gaming paradise spread across three buildings! Here’s a quick look at how to get around and enter each building.

For more maps & entry details visit PAXwest25.com/Maps

World Map of PAX West
A) Summit - Entrance at 9th & Pine
B) Arch - Entrance at 7th & Pike
C) Arch (FKA Annex) - Entrance at 8th & Pike

How To: Queue for entry into the Arch Expo Hall. Doors open at 10:00 am each day.

How to: Queue for entry into the Summit Building. Doors open at 10:00 am each day.

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Jeff Calhoun @calhoujd.bsky.social · Aug 15

A well earned rest!!

Jeff Calhoun @calhoujd.bsky.social · Aug 14

I don't work with fruit flies but even I know how important FlyBase is. Such sad news. 😞

Dr Sian Gramates @drglam.bsky.social · Aug 13

News via The Transmitter www.thetransmitter.org/community/ha...

Harvard University lays off fly database team

The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

www.thetransmitter.org

Jeff Calhoun @calhoujd.bsky.social · Aug 13

This looks super interesting, thanks for sharing!

Reposted by Jeff Calhoun

bioRxiv Genetics @biorxiv-genetic.bsky.social · Aug 11

EpiPred: A gene-specific machine learning model for classifying missense variants in the epilepsy-related gene STXBP1 https://www.biorxiv.org/content/10.1101/2025.08.09.669488v1

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Jeff Calhoun @calhoujd.bsky.social · Jul 18

These are so rad!! Love your work 🤩

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Jeff Calhoun @calhoujd.bsky.social · Jul 18

Happy birthday Gonzo!

Jeff Calhoun @calhoujd.bsky.social · Jul 11

This looks super interesting, can't wait to read it!

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Reposted by Jeff Calhoun

Sriram Pendyala @treependyala.bsky.social · Jul 7

🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇

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Jeff Calhoun @calhoujd.bsky.social · Jun 18

Looks like a very useful resource, thanks for putting it together. Shared it in our lab slack!

Reposted by Jeff Calhoun

Jeremy Berg @jeremymberg.bsky.social · Jun 12

I couldn't sleep last night and skimmed through the names on the #BethesdaDeclaration support letter page.

First, the good news.

(1) There were 18,000+ names and it took me 3 hours.

1/n

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Reposted by Jeff Calhoun

Atlas of Variant Effects Alliance @varianteffect.bsky.social · Jun 6

Thank you to all who joined us in person or online for #VariantEffect25 🌟
📺 Symposium talks are now available on our Youtube channel www.youtube.com/@cmap_cegs8443

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Reposted by Jeff Calhoun

clare-turnbull.bsky.social @clare-turnbull.bsky.social · Jun 6

See our new paper in @ajhgnews.bsky.social :
Validating data from multiplex assays of variant effect: A CanVIG-UK national survey of NHS clinical scientists
Explores blocks to implementing MAVE data into clinical variant interpretation ‪@varianteffect.bsky.social‬
authors.elsevier.com/a/1lDFkgeXDyy6

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Jeff Calhoun @calhoujd.bsky.social · Jun 3

ofc said playlist will need a proper name, something along the lines of Kathleen’s LoFi beats to stab to

Jeff Calhoun @calhoujd.bsky.social · Jun 3

@kathleen.loadingreadyrun.com Hi Kathleen, on recent TTC Q&A you mentioned sharing a curated lofi beats playlist with @coachnelly.bsky.social any chance you’d share here on blusky too? thanks!! 🙏

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Jeff Calhoun @calhoujd.bsky.social · Jun 3

Hey @plasmidsaurus.bsky.social, have you heard of DinoCon? 🦖🦕

Darren Naish @tetzoo.bsky.social · Jun 3

Things #DinoCon are REALLY coming along as ticket sales have gone into overdrive. Schedule out; most presenters and speakers have now been announced. The biggest and best dinosaur-themed meeting the UK has EVER seen, join us at the University of Exeter, Aug 16th and 17th. Book now: www.dinocon.co.uk

DinoCon

www.dinocon.co.uk

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Reposted by Jeff Calhoun

Joshua Weitz @joshuasweitz.bsky.social · May 31

How bad will it be? Catastrophic.

Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come.

But, this is the WH's *proposed* budget.

Speak up now before it is too late.

(inflation adjusted $-s below)

NSF, NASA and NIH budgets per year, inflation adjusted from 2000-2025 along with the proposed cuts. NSF includes research component only. Massive cuts across all sectors, well below support spanning 25 years.

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Reposted by Jeff Calhoun

Coalition to Cure CHD2 @curechd2.bsky.social · May 30

Very excited about latest report from @igorulitsky.bsky.social's lab
using an ASO to upregulate CHD2 expression!

Igor Ulitsky @igorulitsky.bsky.social · May 29

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...

Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression

Modes of action of long noncoding RNAs (lncRNAs) are poorly understood. CHASERR is a broadly expressed lncRNA located immediately upstream of the promoter of the CHD2 gene. We show that antisense olig...

biorxiv.org

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Reposted by Jeff Calhoun

Jeff Calhoun @calhoujd.bsky.social · May 25

CliPE now available in STAR Protocols: www.sciencedirect.com/science/arti...

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Jeff Calhoun @calhoujd.bsky.social · May 25

CliPE now available in STAR Protocols: www.sciencedirect.com/science/arti...

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Jeff Calhoun @calhoujd.bsky.social · May 21

@tychobrahe.bsky.social Have you been keeping tabs on Monster Train 2? Curious to hear your thoughts at some point!

Jeff Calhoun @calhoujd.bsky.social · May 20

Sometimes I clone with 5+ year expired NEB enzymes just to feel something.

a cartoon character says let 's in front of a green wall

ALT: a cartoon character says let 's in front of a green wall

media.tenor.com

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Reposted by Jeff Calhoun

Annie Waldman @anniewaldman.bsky.social · May 7

We are continuing to look into grant terminations at the NIH, and we want to hear from you.

Please reach out to us with your experiences: www.propublica.org/getinvolved/...

Did You Work on a Terminated NIH Grant? ProPublica Wants to Hear From You.

The National Institutes of Health is canceling grants that are seen as conflicting with the Trump administration’s priorities. We want to hear from researchers who have been affected.

www.propublica.org

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