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cameo3d.org
CAMEO-3D
@cameo3d.org
21 followers 1 following 10 posts
https://www.cameo3d.org/ CAMEO (Continuous Automated Model EvalutatiOn) is a community project to continuously evaluate the accuracy and reliability of 3D complex structure predictions. Developed by @sib.swiss and @biozentrum.unibas.ch.
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cameo3d.org
CAMEO-3D @cameo3d.org · Aug 27
🔬 Workshop: Future of Structure Prediction Benchmarking
📅 Sept 8, 2025 | Basel
💡 Talks + breakout sessions on #CASP #CAPRI #CAMEO & benchmarking for drug discovery
🎟️ Free registration (limited spots): lu.ma/ws9nu1xf
Join us to explore how benchmarking can drive breakthroughs in structure prediction.
The future of structure prediction benchmarking: measuring progress and breakthroughs · Luma
Benchmarking has been a key driver of progress in protein structure prediction methods. As the field continues to evolve, several key questions prevail: How…
lu.ma
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cameo3d.org
CAMEO-3D @cameo3d.org · Aug 8
Runs N' Poses is a great example of how to rigorously filter protein–ligand complexes for structural similarity: www.biorxiv.org/content/10.1....
Figure 4 in the Runs N' Poses paper shows how one can combine sequence identity with ligand similarity metrics to assess the structural novelty of protein-ligand complexes.
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cameo3d.org
CAMEO-3D @cameo3d.org · Aug 8
💡Note: these are sequences where the only template available is < 40% sequence identity, making it already a stricter scenario than usual splits with 2021 training cutoffs.
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cameo3d.org
CAMEO-3D @cameo3d.org · Aug 8
Even at 40% sequence identity, SWISS-MODEL models have an LDDT greater than 0.7 on average. If you want to build a meaningful validation set without leakage, you need to adopt a significantly more stringent criterion.
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cameo3d.org
CAMEO-3D @cameo3d.org · Aug 8
We looked at 3891 past CAMEO targets (January 2020 to April 2024). We plotted the LDDT of homology-based SWISS-MODEL prediction against the sequence identity of the top BLAST template, filtering for hits with at least 80% coverage of the target sequence.
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cameo3d.org
CAMEO-3D @cameo3d.org · Aug 8
Filtering out homologous structures from the PDB at 40% sequence identity is not enough to create a robust test set. Significant leakage persists at this level, and comparative modeling can still produce high quality models.
Scatter plot of LDDT as a function of sequence identity for high coverage homology models. The horizontal red line at 40% sequence identity highlights the presence high quality models in the low sequence identity region.
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cameo3d.org
CAMEO-3D @cameo3d.org · Apr 28
Create your account and register your server now!
cameo3d.org
The "Create a new server" button
cameo3d.org
CAMEO-3D @cameo3d.org · Apr 28
Detailed per-target scores and interactive 3D visualization.
The target page with server results and superposed 3D structures.
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cameo3d.org
CAMEO-3D @cameo3d.org · Apr 28
Custom timeframes, automatic server comparisons on shared targets, multi-metric evaluations, and interactive boxplots for selected servers.
The CAMEO results page with custom timeframes, common subset comparison, and boxplots
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cameo3d.org
CAMEO-3D @cameo3d.org · Apr 28
Introducing CAMEO Structures & Complexes - automated weekly blind benchmarking of structure prediction servers. Now with heteromeric and protein-ligand complexes.
Join us and register your server now!
cameo3d.org
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