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Cancer Grand Challenges @cancergrand.bsky.social · 15h

New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development.

Read more: www.cancergrandchallenges.org/news/early-c...

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Cancer Grand Challenges @cancergrand.bsky.social · 1d

“If we can stop cachexia, we can help patients live better — and longer.” - Tobias Janowitz, Co-Lead of team CANCAN.

If you have access, discover how their work could change the way we treat one of cancer’s most overlooked challenges 👉 www.thetimes.com/uk/science/a... #CancerGrandChallenges

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Cancer Grand Challenges @cancergrand.bsky.social · 5d

#CancerGrandChallenges IMAXT in @nature.com:
Using CloneSeq-SV, the team tracked ovarian cancer clones and found:

• Resistant clones often exist from diagnosis
• ctDNA spotted recurrence ~8 months earlier than imaging
• Actionable drivers (e.g. ERBB2) can be revealed

www.nature.com/articles/s41...

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Cancer Grand Challenges @cancergrand.bsky.social · 7d

Targeted protein degraders could change how we treat childhood cancers.

John Buell of team KOODAC explains how our global team is working to develop safer, more effective therapies through #CancerGrandChallenges.

Find out more: koodac.com/scientific-e...

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Cancer Grand Challenges @cancergrand.bsky.social · 12d

Today marks the 1st #CancerCachexiaAwarenessDay. Cachexia affects up to 80% of people with advanced cancer.

Our #CANCAN team is uncovering its biology & building the world’s first virtual cachexia institute.

🔗 www.cancergrandchallenges.org/news/demysti...

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Cancer Grand Challenges @cancergrand.bsky.social · 21d

This Childhood Cancer Awareness Month, we’re highlighting progress against childhood solid tumours.

Our teams are working to advance next-gen CAR-T therapies & protein degraders—bringing hope for a future with safer, more effective treatments www.cancergrandchallenges.org/news/tacklin...

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Cancer Grand Challenges @cancergrand.bsky.social · Sep 8

Published today in @aacrjournals.bsky.social Imran Noorani & @magnushaughey.bsky.social share the first evidence that ecDNA can build up in the healthy brain before tumours form in #glioblastoma — pointing to new early intervention strategies.

👉 www.cancergrandchallenges.org/news/ecdna-u...

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Cancer Grand Challenges @cancergrand.bsky.social · Sep 5

Interesting @economist.com piece on #CancerGrandChallenges team Mutographs, Phil Jones (@sangerinstitute.bsky.social) & Sci Committee Chair Charles Swanton. Their work reshapes how we think about cancer’s origins - A great read if you have access.

👉 www.economist.com/science-and-...

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Cancer Grand Challenges @cancergrand.bsky.social · Sep 5

New opinion piece by Tobias Janowitz at @cshlnews.bsky.social‬ & team CANCAN: Of Hope from Fading Will.

How cancer influences brain–body communication, why #cachexia may begin as an adaptive response, and how patient-reported symptoms can guide new interventions
👉 www.cell.com/neuron/fullt...

Neuron @cp-neuron.bsky.social · Sep 3

We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:

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Cancer Grand Challenges @cancergrand.bsky.social · Aug 29

Congratulations to #CancerGrandChallenges MATCHMAKERS team member Regina Barzilay for making the 2025 #TIME100 list of global #AI leaders!

At ‪@aihealthmit.bsky.social‬, Regina has advanced cancer prediction and antibiotic discovery—and is now tackling our TCR challenge to transform #immunotherapy

MIT Jameel Clinic @aihealthmit.bsky.social · Aug 28

We're thrilled to share that @aihealthmit.bsky.social faculty lead Regina Barzilay has been included in TIME's list of #TIME100AI for 2025! 👏
📢Full Announcement: jclinic.mit.edu/regina-barzi...
📰More from TIME: time.com/collections/... #AISky

Photo of Regina Barzilay seated at her desk looking at the camera. The photo is framed by a black and red graphic that also reads "TIME100/AI 2025"

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Cancer Grand Challenges @cancergrand.bsky.social · Aug 29

@natrevendo.nature.com‬ examines the links between obesity, T2DM, inflammation & microbiome disruption to rising early-onset colorectal cancer.

Featuring teams PROSPECT, CANCAN, and co-authors 👉 www.nature.com/articles/s41... #EOCRC #TeamScience

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Cancer Grand Challenges @cancergrand.bsky.social · Aug 22

An interesting perspective in Molecular Cell from Cristina Mayor-Ruiz (team PROTECT), Georg E. Winter (team KOODAC), Alessio Ciulli (team KOODAC and co-authors - Opportunities in proximity modulation: Bridging academia and industry #CancerGrandChallenges

IRB Barcelona @irbbarcelona.org · Aug 21

🤝 #IRBBarcelona Group Leader Cristina Mayor-Ruiz has co-authored a Perspective in #MolecularCell proposing the creation of a #EuropeanAlliance to accelerate the development of proximity-induced therapies.

More information here 🔗 www.irbbarcelona.org/en/news/scie...

🧪 #TargetedProteinDegradation

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Cancer Grand Challenges @cancergrand.bsky.social · Aug 22

“...exploring why people don’t get cancer... could give us a greater understanding... and could potentially lead to new ways to think about cancer prevention” - Karen Vousden, @crick.ac.uk & #CancerGrandChallenges Scientific Committee Member talking about our cancer avoidance challenge.

Undark Magazine @undark.org · Aug 18

Historically, cancer research has probed the drivers of the disease’s evolution. But some scientists are widening their scope to study patients who survive against the odds.

🔗: https://undark.org/2025/08/11/cancer-super-survivors/

Cancer Grand Challenges @cancergrand.bsky.social · Aug 22

Fascinating interview! Howard Chang shares insights on ecDNAs and his long-standing collaboration with Paul Mischel, both of which were central to his time as a co-investigator on #CancerGrandChallenges team eDyNAmiC whilst at Stanford University.

Nature Reviews Drug Discovery @natrevdrugdiscov.nature.com · Aug 14

From gene hunter to drug hunter
www.nature.com/articles/d41...

Howard Chang, Amgen’s new CSO, discusses genetic target discovery, extrachromosomal DNA and technology development

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Cancer Grand Challenges @cancergrand.bsky.social · Aug 20

After nearly a decade of leadership, Margaret Grayson MBE reflects on her time as Chair of the #CancerGrandChallenges Advocacy Panel. Thank you Margaret for embedding the voices of those affected by cancer into discovery research.

features.cancerresearchuk.org/cancergrandc...

DFS 0161 CGC Discover mag 2024 — Patient advocacy

A year of scientific creativity

features.cancerresearchuk.org

Cancer Grand Challenges @cancergrand.bsky.social · Aug 11

Prof Kimmie Ng, one of our leading #CancerGrandChallenges scientists, discusses the drivers behind early onset colorectal cancer with ‪The New York Times #EOCRC

nytimes.com/2025/08/02/w...

How Your Diet Influences Your Colorectal Cancer Risk

nytimes.com

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