Caspar Geenen
@caspargeenen.bsky.social
92 followers 130 following 13 posts
Working on a PhD at Clinical Microbiology Lab, KU Leuven. Investigating new ways to track the spread of infections. #IDEpi
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Reposted by Caspar Geenen
jellematthijnssens.bsky.social
🚨 New paper in Eurosurveillance - @karatasmustafa.bsky.social
We used shotgun metagenomics on indoor air in a Belgian daycare to track respiratory, enteric & skin viruses.
👉 40/42 samples contained human viruses—even when kids seemed healthy!
📄 Read here: pubmed.ncbi.nlm.nih.gov/41000028/
Reposted by Caspar Geenen
karatasmustafa.bsky.social
New paper out!

We sampled indoor air for a year in a Belgian daycare and used shotgun metagenomics to track viruses. We recovered many viral genomes of interest.

What would you sample next?

Read at @eurosurveillance.org
@emmanuel-microb.bsky.social, @jellematthijnssens.bsky.social
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Figure 3. (A–N) Sequencing coverage plots of genetic sequences of viruses detected in indoor air samples of a daycare and phylogenetic analyses of sequences of (O) two human bocaviruses and (P) one RSV identified in some samples, Belgium, January–December 2022
caspargeenen.bsky.social
New study on reaching people with undiagnosed tuberculosis in Rwanda: “… our results suggest that analyzing satellite imagery may allow the identification of urban areas where inhabitants are at higher risk of tuberculosis.”
Reposted by Caspar Geenen
yassentch.bsky.social
One of my favorite #ESCMIDGlobal sessions is "Year in #PublicHealth".
Yi Lang Hsu summarizes outbreaks that occurred in the last year: Mpox, Avian Influenza, Marburg, Oropouche!
#PublicHealthSky #IDsky #ESCMIDGlobal2025
Reposted by Caspar Geenen
Reposted by Caspar Geenen
Reposted by Caspar Geenen
docmundele.bsky.social
New publication by Christelle Jouego & cols. maps TB hotspots in Cameroon using OpenStreetMap & WorldPop data. Reveals up to 53% of TB cases go undiagnosed in some regions 🧐. Urgent need to reallocate diagnostic tools where they're needed most. #GlobalHealth #TB www.nature.com/articles/s41...
Mapping of regions with low tuberculosis notification and estimation of diagnostic gaps in Cameroon, evidence from OpenStreetMap and WorldPop data
Scientific Reports - Mapping of regions with low tuberculosis notification and estimation of diagnostic gaps in Cameroon, evidence from OpenStreetMap and WorldPop data
www.nature.com
caspargeenen.bsky.social
3️⃣ Scaling up:
A single air sample from a central ventilation shaft could capture infections of many people in a building.
(Michiel Happaerts et al, Indoor Air)

In the future, maybe a small number of busy sentinel sites could be enough to help anticipate and monitor epidemics…
Centralised Air Sampling From a Ventilation System for the Surveillance of Respiratory Pathogens
Background: The COVID-19 pandemic has triggered a renewed interest in indoor air sampling for infectious disease surveillance. However, scalability is currently limited, as samples are usually collec...
onlinelibrary.wiley.com
caspargeenen.bsky.social
This builds on previous work at our Clinical Microbiology Lab:

1️⃣ In one study, we found on average 3.9 pathogens in 341 air samples from 21 locations, from bars to care homes.

Takeaways:
- Poor ventilation = more pathogens in air
- Air samples can mirror epidemiology

(Raymenants et al, Nat Comms)
Indoor air surveillance and factors associated with respiratory pathogen detection in community settings in Belgium - Nature Communications
Surveillance of respiratory pathogens in air may improve understanding of indoor transmission risks but impacts of context-specific factors on pathogen abundance are not well understood. Here, the aut...
www.nature.com
caspargeenen.bsky.social
“The results highlight the differing shedding patterns between pathogens, while supporting the use of air pathogen counts and CO2 concentrations to estimate population-level prevalence.”

The relevance of this study and avenues for future research are highlighted in a comment by John Lednicky:
New questions and avenues for research regarding interpretation of the significance of respiratory viruses adrift in the air
Respiratory infections are the leading reason for hospitalisations worldwide.1 While numerous human respiratory viruses have been identified, the manner by which they are transmitted person-to-person ...
lancet.com
caspargeenen.bsky.social
New study: analysing indoor air to detect outbreaks.

“… Air sampling could provide sensitive, responsive #epidemiology indicators for surveillance of respiratory pathogens…”

See thread for details and previous air sampling work with @emmanuel-microb.bsky.social

#IDEpi #IDsky #PedsID #KULeuven 🛟
Heatmap chart showing the detection of various pathogens over different sampling weeks (W9 to W30). Pathogens are listed on the y-axis, including viruses and bacteria such as Streptococcus pneumoniae, human coronaviruses, influenza viruses, and others. The x-axis represents the sampling weeks. Black dots indicate detection of the pathogen in the air. The colour gradient, ranging from white to dark red, represents the proportion of positive paper tissue samples, with darker shades indicating higher proportions. This alt text was generated by ChatGPT. A chart showing the relative detection of pathogens in air versus paper tissues, with pathogens listed on the y-axis (e.g., Pneumocystis jirovecii, herpes simplex virus type 1, SARS-CoV-2). The x-axis represents ∆Ct values, where negative values indicate higher detection in air and positive values indicate higher detection in paper tissues. Red dots represent the mean ∆Ct for each pathogen, and horizontal red error bars represent the 95% confidence intervals. Individual grey dots indicate data points for each sample. Pathogens are arranged by their relative prevalence in air and paper tissues. This alt text was generated by ChatGPT.
Reposted by Caspar Geenen
jellematthijnssens.bsky.social
🚨 #PhDPosition Opportunity Alert 🚨
Join the Matthijnssens-lab @KU_Leuven to explore the early-life #virome dynamics and their impact on immunity in infants from Ghana & Zambia! 🌍🧬
📅 Start: June 2025
🔗 kuleuven.be/personeel/jobs…#microbiomem#bioinformaticsc#phageg#NGSGS
https://kuleuven.be/personeel/jobs…
Reposted by Caspar Geenen
caspargeenen.bsky.social
IDEpi: a dedicated Bluesky feed for Infectious Disease Epidemiology.

This feed collects posts tagged with #IDEpi or keyword combinations like #IDSky + #EpiSky.
Comments and suggestions welcome!

Access here: bsky.app/profile/did:...
caspargeenen.bsky.social
4️⃣ Not large super-spreading events, but many small gatherings caused a surge in COVID-19 transmission on New Year’s Eve (2022).
(Sci Rep)

Of course, the virus was a bigger concern back then. Wishing everyone a happy, festive start to 2025!

Stay tuned as we work to prepare for future pandemics.
Unravelling the effect of New Year’s Eve celebrations on SARS-CoV-2 transmission - Scientific Reports
Scientific Reports - Unravelling the effect of New Year’s Eve celebrations on SARS-CoV-2 transmission
www.nature.com
caspargeenen.bsky.social
Hello Bluesky! A quick overview of what we learned doing contact tracing for COVID-19 at KU Leuven.

#IDEpi #PublicHealth #EpiSky #IDSky @Emmanuel_microb

1️⃣ Tracing sources of infections (backward contact tracing) could efficiently slow COVID-19 spread.
(Raymenants, Geenen, et al; Nat Comms)

More👇
Empirical evidence on the efficiency of backward contact tracing in COVID-19 - Nature Communications
Backward contact tracing aims to identify individuals who were infected by the same person as infected an index case, and has been shown to be effective in modelling studies of SARS-COV-2. Here, the a...
www.nature.com