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Reposted by Cassie Clarke

Cancer Research UK Scotland Institute @cruk-si.bsky.social · 29d

We are delighted to be offering summer placements in 2026 with #In2research

Learn more about the programme and application process at their information session next week - Monday 15 September

👉Register for the session here: ow.ly/VNg750WP8bf

2025/26 In2research Participant Information Sessions

Are you interested in doing a PhD but aren’t sure how to get there? Then get In2research!

ow.ly

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Cassie Clarke @cassiejclarke.bsky.social · 29d

Super proud to see our work featured on the cover of @emboreports.org today. Many thanks to @pedromics.bsky.social for this beautiful interpretation and depiction of our story. Read the associated paper here: www.embopress.org/doi/full/10....

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Reposted by Cassie Clarke

Nature Metabolism @natmetabolism.nature.com · Aug 21

RESEARCH |

@simonsterson.bsky.social‬ @katajistolab.bsky.social‬ et al.

Intestinal stem cells enriched for old mitochondria have enhanced ability to regenerate the epithelial niche 🧪

https://bit.ly/3HwPkb3 ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism

Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

bit.ly

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Cassie Clarke @cassiejclarke.bsky.social · Jul 28

🧪🧪🧪 To the science feed you go... #neutrophils #metabolism #metastasis #BBCRadioScotland #GoodMorningScotland

Cassie Clarke @cassiejclarke.bsky.social · Jul 28

It was a pleasure to speak to Lucy Whyte this morning on #BBCRadioScotland to discuss our recent @emboreports.org publication which has discovered how #neutrophil #metabolism facilitates #metastasis. Catch up with interview here: www.youtube.com/watch?v=tUUw...

Dr Cassie Clarke CRUK Scotland Institute - breast cancer research

YouTube video by Fiona MacLeod

www.youtube.com

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Cassie Clarke @cassiejclarke.bsky.social · Jul 28

And the original publication is here:
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibronectin deposition and support metastatic niche ...

share.google

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Cassie Clarke @cassiejclarke.bsky.social · Jul 28

It was a pleasure to speak to Lucy Whyte this morning on #BBCRadioScotland to discuss our recent @emboreports.org publication which has discovered how #neutrophil #metabolism facilitates #metastasis. Catch up with interview here: www.youtube.com/watch?v=tUUw...

Dr Cassie Clarke CRUK Scotland Institute - breast cancer research

YouTube video by Fiona MacLeod

www.youtube.com

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇

Cassie Clarke @cassiejclarke.bsky.social · Jul 23

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

www.embopress.org

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

This work has been highly collaborative & I thank all co-authors,collaborators,facilities & funders.Special thanks to Declan Whyte & Jim Norman for their invaluable contributions & #CRUK @cruk-si.bsky.social, @breastcancernow.bsky.social & @pancreaticcanuk.bsky.social for making this possible(14/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

Exciting clinical opportunities from these observations include understanding whether circulating #uracil can be used as a #biomarker to detect metastatic disease, & whether UPP1 inhibitors can decrease the risk of distant metastasis &/or improve responses to immunotherapy (13/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

Collectively our data show that #neutrophils are a significant source of UPP1 in cancer, that UPP1 influences the immunosuppressive & motile behaviour of neutrophils & ECM deposition in lung, & in the absence of UPP1 the ability of mammary tumours to metastasise is reduced (12/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

And indeed, we found that, in mouse models of #mammary #cancer, knockout of UPP1 decreases the proportion of mice with lung metastasis, whilst knockout of UPP1 in mouse models of #pancreatic #cancer decreases local invasion at the primary tumour (11/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

Thus far our data indicated that UPP1 can influence neutrophil behaviour, T-cell number and ECM deposition in the lungs of tumour-bearing mice, suggesting that UPP1 can make key contributions to establishment of #niches that support progression of #metastatic disease…. (10/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

Mechanistically, extracellular uracil supported increased recycling of cell surface receptors in fibroblasts, including fibronectin receptor integrin a5b1, resulting in deposition of a fibronectin-rich matrix that supported increased invasive potential of cancer cells (9/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

#ECM deposition is also a key feature of niche priming. We found that deposition of #fibronectin in the metastatic lung was reduced in the absence of #UPP1 & that #uracil (derived from UPP1-expressing neutrophils) can directly influence the ECM deposited by #fibroblasts (8/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

In line with this, we find that whilst UPP1-expressing neutrophils from tumour-bearing mice can inhibit T-cell proliferation, neutrophils from tumour-bearing mice that lack UPP1 have a reduced ability to inhibit T-cell proliferation (7/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

We hypothesised that UPP1-driven alterations to neutrophil phenotype might also affect the landscape of other immune cell types in metastatic target organs. In the absence of UPP1 we found there was an increase in the number of IL-2+ T Cells in the metastatic lung (6/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

Neutrophils play key roles in #niche #priming. We thus investigated how UPP1 influences neutrophils in metastatic target organs. Building on the work of @bair-head.bsky.social lab, we found that tumour-induced alterations to neutrophil motility were dependent on UPP1 expression/activity (5/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

We find that primary tumours increase expression of UPP1 in neutrophils, that uracil derived from UPP1-catalysed cleavage of uridine is secreted from neutrophils into the extracellular environment & depletion of neutrophils from tumour-bearing mice decreases serum uracil (4/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

Uracil is generated by the enzyme #UPP1. Whilst previous studies, including the beautiful work of @lyssiotislab.bsky.social and @jourdainlab.bsky.social have focused on tumour-specific UPP1, we have found that #neutrophils are a significant source of UPP1 in metastatic cancer (3/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

To identify #metabolites associated with #metastasis we characterised the circulating metabolome of genetically engineered mouse models of cancer, and found the metabolite #uracil to positively correlate with metastasis in models of breast, pancreatic & colon cancer (2/14)

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

www.embopress.org

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Reposted by Cassie Clarke

Guillaume Jacquemet @guijacquemet.bsky.social · Jul 1

- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).

Guillaume Jacquemet @guijacquemet.bsky.social · Jun 23

Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!

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Cassie Clarke @cassiejclarke.bsky.social · Jun 23

It was a pleasure to visit @sheffielduni.bsky.social
last week presenting our work "Neutrophil metabolism faciliates metastasis by influencing immune & ECM landscapes" at @mcb-sheffield.bsky.social seminar series.Thanks @erainerolab.bsky.social for the invitation & all who made it a memorable visit

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Reposted by Cassie Clarke

Mass Lab @masslab.bsky.social · Jun 18

We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b

Kupffer cell programming by maternal obesity triggers fatty liver disease

Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

rdcu.be

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Reposted by Cassie Clarke

Christian Frezza @frezzalab.bsky.social · Jun 15

Good morning, all. Science keeps making excellent progress. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

The boundary to what we can accept is the boundary to our freedom.
Tara Brach

a penguin is reading a newspaper while another penguin looks on

ALT: a penguin is reading a newspaper while another penguin looks on

media.tenor.com

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