Mauro Castelló Sanjuán
banner
castellosanjuan.bsky.social
Mauro Castelló Sanjuán
@castellosanjuan.bsky.social
PhD candidate at the @salehlab.paris.bsky.social 🪰🧬- Institut Pasteur (Paris, France 🥐)
4-Me working with @rubengonzalez.bsky.social. Text caption "Got to supervise my own post-doc (Rubén)"
October 22, 2025 at 9:17 AM
2-A screenshot of my phone gallery showing all the sheets of manually recorded data. Text caption "This is a Snapshot of what my life has been"

3-The fly incubator with fly drawings all around, all customized. Text caption "Mum let me decorate my room"
October 22, 2025 at 9:17 AM
I will think about this next time! Sorry I missed it here. Here is the description of the pics:

1- A cartoon of a sick Drosophila melanogaster, wearing a mask, and surrounded by four viruses of different colours (the viruses of the study)
October 22, 2025 at 9:17 AM
(5/5)
Thanks to all members of the @salehlabparis.bsky.social for support and teamwork; couldn't have done it without you 🫶

Thanks to @pasteur.fr for hosting me during my PhD journey😄👨‍🔬

The corrected proofs are out! Read the full article at @plosbiology.org : plos.io/4olpuXmm
Persistent viral infections impact key biological traits in Drosophila melanogaster
Persistent viral infections in insects are not as harmless as once believed. This study reveals how such infections in fruit flies alter survival, reproduction, behavior, and gene expression, offering...
plos.io
October 17, 2025 at 2:07 PM
Having shared that...

(4/5)
We found that:

*Persistence reduces fly survival

*Hosts trade reproduction for immunity

*Persistently infected flies have impaired movement and altered sleep, but keep circadian rhythm

*Different viruses trigger distinct transcriptional responses

*And more!
October 17, 2025 at 2:07 PM
(3/5)
But first, I wanna share some sneak peeks of how this work has come to be, how I made the lab home, and the bonding that comes with working closely:
October 17, 2025 at 2:07 PM
(2/5)
In our latest work, we established persistent viral infections to examine their impact on this model organism.
We followed survival and other life history traits, and we also performed a transcriptomic analysis over time… (The data is available for you to play with it! 💻🧬🪰)
October 17, 2025 at 2:07 PM