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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · 4d

www.biorxiv.org/content/10.1...

Pericyte-tumor crosstalk facilitates metastatic tumor cell latency through PIEZO1-activated lysophospholipid transfer

Tumor dissemination is increasingly recognized to begin early in tumor development. Although most of these early disseminated cells are cleared, some survive and persist below clinical detection, acti...

www.biorxiv.org

Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Sep 1

Congrats to Shoichiro Takeishi, @steidluli.bsky.social @gritsmanlab.bsky.social and co-authors on this fascinating discovery! @cdi-einstein.bsky.social @einsteincellbio.bsky.social

Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Sep 1

New findings by CDI members @steidluli.bsky.social @gritsmanlab.bsky.social et al.,reveal how HSC numbers are controlled by both systemic & local (niche) mechanisms, primarily regulated by thrombopoietin, even with increased niche capacity. Congrats to all! www.nature.com/articles/s41...

Haematopoietic stem cell number is not solely defined by niche availability - Nature

Haematopoietic stem cell numbers are restricted at both systemic and local levels.

www.nature.com

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Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 19d

Excited about a day of exceptional cancer science being developed at our @einsteinmededu.bsky.social comprehensive cancer center. Featuring science being developed at our Cancer Dormancy Institute @cdi-einstein.bsky.social - proud to be part of this amazing community

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Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 15d

Delighted to have opened this fantastic meeting in beautiful Thessaloniki organized by the equally amazing Evi Lianidou presenting updates from the lab @cdi-einstein.bsky.social including our CH collaborative work with @rosslevinemd.bsky.social lab.

www.erasmus.gr/microsites/1...

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Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 12d

I could not stay the entire meeting but it was great seeing friends and colleagues Evi Lianidou, Angela Nieto AndreasTrumpp Caroline Dive and many more at the 7th ACTC Meeting in Thessaloniki, Greece. Great to bring the science we are developing @cdi-einstein.bsky.social to this meeting.

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Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 11d

Delighted to host Dr. Javier Bravo Cordero at our Cancer Dormancy Institute Seminar Series. Don't miss his exceptional work! @cdi-einstein.bsky.social @einsteinmededu.bsky.social @einsteincellbio.bsky.social

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Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 7d

oncodaily.com/voices/metas.... Thanks for sharing this post with a broader audience @oncodaily.bsky.social the goal of our @cdi-einstein.bsky.social is to bring new science for interception of metasasis / recurrence and MRD at its earliest point.

Julio Aguirre-Ghiso: Metastasis and the Real Causes of Cancer Mortality - OncoDaily

Julio Aguirre-Ghiso: Metastasis and the Real Causes of Cancer Mortality / Adrienne Boire, Alexander Yang, Allison W. Kurian, Amy B. Knudsen, Amy

oncodaily.com

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Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 6d

Great @cdi-einstein.bsky.social seminar by Jose Javier Bravo Cordero from @mountsinainyc.bsky.social covering ECM architecture, metabolism and neuroscience. Fantastic work! Thanks for visiting us!

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Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 5d

Amazing work from investigators at the @cdi-einstein.bsky.social. Congrats @divijverma.bsky.social and team! Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion url: aacrjournals.org/cancerdiscov...

Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion

Abstract. Environmental exposures are linked to precancerous hematologic conditions, but studies in cohorts with well-defined exposures are limited. We sequenced blood samples from a large cohort of f...

aacrjournals.org

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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Sep 4

New work from CDI Member Dr. David Fooksman- Congrats! www.cell.com/cell-reports...

CD138 and APRIL regulate plasma cell survival, competition, and retention in the bone marrow niche

Survival of new PCs after vaccination is highly variable, inefficient, and poorly understood. Park et al. demonstrate that higher cell-intrinsic CD138 levels control PC survival in competitive environ...

www.cell.com

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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Sep 4

New study from CDI member Rachel Hazan. Congrats!
www.nature.com/articles/s41...

Wnt/ERK/CDK4/6 activation in the partial EMT state coordinates mammary cancer stemness with self-renewal and inhibition of differentiation - British Journal of Cancer

British Journal of Cancer - Wnt/ERK/CDK4/6 activation in the partial EMT state coordinates mammary cancer stemness with self-renewal and inhibition of differentiation

www.nature.com

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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Sep 4

Important study showing that targeting dormant residual disseminated cancer cells can reduce MRD burden by Angela DeMichele, collaborator and Lewis Chodosh @penncancer.bsky.social who will be Keynote Speaker at our next CDI retreat! Congratulations!

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Sep 4

Pioneering trial targeting dormant residual cancer cells by L. Chodosh, A. DeMichele et al., @penncancer.bsky.social Proof-of-concept that targeting dormant RTCs in breast cancer survivors depletes MRD. NCT03032406. Congratulations for this work! www.nature.com/articles/s41...

Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial - Nature Medicine

A combination of mouse model data and data from a randomized phase 2 trial in patients with breast cancer in remission demonstrates feasibility, safety and a reduction in residual tumor cells followin...

www.nature.com

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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Sep 1

New findings by CDI members @steidluli.bsky.social @gritsmanlab.bsky.social et al.,reveal how HSC numbers are controlled by both systemic & local (niche) mechanisms, primarily regulated by thrombopoietin, even with increased niche capacity. Congrats to all! www.nature.com/articles/s41...

Haematopoietic stem cell number is not solely defined by niche availability - Nature

Haematopoietic stem cell numbers are restricted at both systemic and local levels.

www.nature.com

4

Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Aug 4

@cdi-einstein.bsky.social @einsteinmededu.bsky.social @einsteincellbio.bsky.social

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Aug 4

Excited to see this new paper with long time friend and collaborator Andrew Aplin on an unexpected function of NR2F1 in melanoma persister biology. Congrats to all! www.jci.org/articles/vie...

JCI - Elevated NR2F1 underlies the persistence of invasive disease after treatment of BRAF-mutant melanoma

www.jci.org

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Reposted by Cancer Dormancy Institute @ Einstein

David Entenberg @dentenberg.bsky.social · Aug 5

Please join me in congratulating the newly minted Dr. Madeline Friedman DeLuca! She did a phenomenal job in her thesis defense today!

#ProudPI

@cdi-einstein.bsky.social @einsteinmededu.bsky.social @monteeinsteinpath.bsky.social

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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Aug 6

montefioreeinsteinnow.org/update/2025-...

Research Team Discovers Natural Immune Mechanism That Stops Metastatic Cancer | Montefiore Einstein Now

A finding by Montefiore Einstein Comprehensive Cancer Center scientists points to new ways to keep dormant cancer cells from reactivating.

montefioreeinsteinnow.org

Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Aug 4

New work from CDI members @wenjunguolab.bsky.social and Gregoire Lauvau published in Immunity. Congrats! www.cell.com/immunity/abs...

Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

Mutations in MLL3, encoding the histone methyltransferase MLL3/KMT2C, are frequent in various cancer types. Boutet, Nishitani, et al. show that the loss of MLL3 stabilizes HIF1α, which induces express...

www.cell.com

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Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Jul 30

Accompanying pieces www.nature.com/articles/d41...

‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu

Inflammation from the respiratory infections seems to be the culprit, study in mice finds.

www.nature.com

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Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Jul 30

www.nature.com/articles/d41...

Inflammation during viral infection can rouse dormant cancer cells

Sometimes, cancer cells that have spread become ‘dormant’ but can start proliferating again later. A cue that can reactivate them has been discovered.

www.nature.com

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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Aug 4

@cdi-einstein.bsky.social Director @jaguirreghisolab.bsky.social co-leads a study showing how viral infections can trigger via IL6 signaling awakening of dormant breast cancer cells in lungs. CDI's research focuses in part on host variations controlling the timing of residual cancer awakening

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Jul 30

Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

www.nature.com

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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Jul 7

www.sciencedirect.com/science/arti...

Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps

Disseminated tumor cells (DTCs) can remain in a non-proliferative, dormant state for years in distant organs, but the exogenous causes triggering thei…

www.sciencedirect.com

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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Jul 2

www.nature.com/articles/s41...

IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis - Nature Immunology

Cellular exhaustion can limit the ability of immune cells to control tumors. Here the authors show that expression of the transcription factor Irf4 marks NK cell percursors that will go on to become e...

www.nature.com

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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Jul 2

www.nature.com/articles/s41...

Neuroprotective liver portal area macrophages attenuate hepatic inflammation - Nature Immunology

Zhang and colleagues characterize a subset of nerve-associated CX3CR1+ liver portal area macrophages that maintain immune homeostasis and attenuate nonalcoholic steatohepatitis.

www.nature.com

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Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Jun 23

www.nature.com/articles/s41...

Reversible proliferative arrest induced by rapid depletion of RNase MRP - Nature Communications

Cellular quiescence is a reversible dormant state that helps cells survive stress, support tissue regeneration, and promote longevity. Here, the authors show that blocking ribosomal RNA production by ...

www.nature.com

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Reposted by Cancer Dormancy Institute @ Einstein

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Jun 6

Great moment with the lab celebrating Lucía Petriz Otaño🇦🇷 passing her PhD qualifying exam and receiving her MSc!! Congratulations! We are very proud of you! @cdi-einstein.bsky.social @einsteincellbio.bsky.social

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