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Centre of Excellence for Long-acting Therapeutics

@celtliverpool.bsky.social

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The Centre of Excellence for Long-acting Therapeutics (CELT) at #livuni is accelerating understanding of #longacting medicines, by combining world leading expertise in pharmacology and materials chemistry to create new interventions.

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Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 4

Ever wondered what the Centre of Excellence for Long-acting Therapeutics (CELT) do?

We identify existing medications we know work and are safe, and create long-acting options. We execute materials chemistry and preclinical pharmacology research.

Find out more:
www.liverpool.ac.uk/centre-of-ex...

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 1d

This #ChildHealthDay we're highlighting our upcoming Community of Practice webinar, hosted by Laxman Cherkupally from @mmv.org on 22 October.

The majority of malaria deaths are children under 5 years old. All malaria work is to protect children health.
events.teams.microsoft.com/event/8ad398...

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 5d

#ManufacturingDay is the last Thursday of September (UK - @makeuk.bsky.social) and the first Friday of October (US)

We're leading the Manufacturing Capability project to create an open resource to show manufacturing capabilities in LMICs:
www.liverpool.ac.uk/centre-of-ex...
@unitaid.bsky.social

a global heat map with pins has the blog title written over the top: We're a preclinical team with a focus on manufacturing capability - Here's why.

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 6d

9 October, CELT's Prajith Venkatasubramanian is delivering a webinar with Dr Leena Zino.

They'll discuss long acting drug delivery systems and the patents / regulatory process.

Find out more about this and other events CELT are at via our event page:
www.liverpool.ac.uk/centre-of-ex...

The event title is at the top with pictures of Prajith Venkatasubramanian and Leena Zino with event times underneath them.

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 7d

The Systems Medicine team have published: Physiologically based pharmacokinetic modelling of serum 25-hydroxyvitamin D concentrations in schoolchildren receiving weekly oral vitamin D3 supplementation

Find a link to the full article and other CELT publications: www.liverpool.ac.uk/centre-of-ex...

A close up image of a vitamin d capsule on a yellow background

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 8d

Teoreler is a free online PBPK modelling application. With support from @unitaid.bsky.social, our team work really hard to continually update Teoreler and add new models.

Find out more if you're new to Teoreler, or leave us feedback if you're not, via the link: www.liverpool.ac.uk/centre-of-ex...

Dr Rajith Rajoli is using modelling software on their computer. Over the image reads "Teoreler: A web-based physiologically based pharmacokinetic (PBPK) modelling application for the simulation and extrapolation of drug use scenarios. This application simulates drug pharmacokinetics of small molecules using complex mathematical equations to predict the efficacy of drugs in the human body in a variety of species and populations."

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Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 9d

28 September was @unesco.org's International Day for Universal Access to Information.

We've told you why we think patients accessing research that represents them is important. Now we can show you how we're doing it.

www.liverpool.ac.uk/centre-of-ex...
#AccessToInfo #AccessToInfoDay #RightToKnow

a group of people are sat in a circle, the text is the blog title "Access to information is mission critical – here’s why and how we’re doing it"

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 12d

News from other long-acting teams:

- @unitaid.bsky.social, Clinton Health Access Initiative and Wits RHI: agreement with Dr Reddy's Laboratories to make affordable lenacapavir
- @unaids.org respond to the announcement of making affordable HIV preventatives.

www.liverpool.ac.uk/centre-of-ex...

A person is holding a vial of lenacapavir

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Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 14d

Next week is our quarterly #LONGEVITYproject newsletter.

This quarter includes:
- Work from partners @treatmentactiongroup.org and CHAI.
- Recent hepatitis C virus proof of concept news
- Community of Practice meeting highlights.

Subscribe: www.liverpool.ac.uk/centre-of-ex...
@unitaid.bsky.social

A woman looks into the sunrise over a beautiful landscape. The text reads "LONGEVITY Project: Aiming to reduce the burden of disease in low- and middle- income countries"

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 16d

Last week's Global News updates from other long-acting therapeutics teams covered:

💉Oruka Therapeutics announced positive interim phase 1 results for long-acting plaque psoriasis treatment.

Find this and other stories on our Global News page: www.liverpool.ac.uk/centre-of-ex...

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 20d

We're hosting ARIA's visit to @liverpooluni.bsky.social, with an introduction from our co-Director Prof. Andrew Owen.

ARIA's Brian Wang will dive into the newly launched programme thesis, Sustained Viral Resilience.

📆 Friday 26 September 2025
🌍 The Victoria Gallery and Museum, Liverpool UK.

The Pandemic Institute @thepandemicinst.bsky.social · Sep 3

Our colleagues @celtliverpool.bsky.social will be hosting ARIA in Liverpool on Sept 26th, 1 PM - 2:30 PM, to hear about their newly launched programme thesis, Sustained Viral Resilience.

To find out more and register:
www.eventbrite.co.uk/e/aria-visit...

ARIA Visit to UoL

Join ARIA's team on September 26th for a session to hear about their newly launched programme thesis, Sustained Viral Resilience.

www.eventbrite.co.uk

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 21d

17 September is #InternationalMicroorganismDay and @who.int's #PatientSafetyDay

We're highlighting #LONGEVITYproject. Explore the impact of the project diseases (HCV, malaria and TB) and our long-acting options work to keep LMIC patients safe from them.

www.liverpool.ac.uk/centre-of-ex...

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Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 22d

It's Postdoc Appreciation Week.

Our postdocs are integral members of our team and research. Our varied and multi-disciplined skill set is broadened dramatically by our brilliant postdocs.

See the projects our postdocs work on: www.liverpool.ac.uk/centre-of-ex...
#LovePostdocs #NPAW2025

Projects | CELT's Projects | Centre of Excellence for Long-acting Therapeutics | Centre of Excellence for Long-acting Therapeutics | University of Liverpool

CELT works on many research projects to develop long-acting therapeutics options to reduce the burden of difficult medication regimens. Read more about them here.

www.liverpool.ac.uk

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 23d

It's #NationalCodingWeek.

We want to highlight:

💉 How important our modellers are in our long-acting therapeutics work
🌍 How they are helping us save lives
🧑‍🔬 How they found their way from pharmacology to modelling
💻 The benefits of coding to other life skills

www.liverpool.ac.uk/centre-of-ex...

Dr Rajith Rajoli is working on some CELT modelling. The blog title is written over the top "Lost on your coding journey? Our pharmacology researchers can help".

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 26d

Recent news from other long-acting teams:

🌍Gilead Sciences partner with PEPFAR
💉@unaids.org: Brazil's HIV PrEP need
👩‍⚕️Foresee: FDA approve long-acting prostate cancer treatment
🔬Lupin: FDA approve long-acting risperidone
📣Health GAP respond to US State Department

www.liverpool.ac.uk/centre-of-ex...

A person is reading the news on their tablet

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 27d

Join Dr Adeniyi Olagunju, from the University of Liverpool's Perinatal Pharmacology group, for webinar 'Unlocking Access to Individual-Level Pharmacokinetic Data via PKRxiv'.

📆 30 September 2025
⏰ 12-1pm (BST)
💻 Online

Find out more and register via the link: www.liverpool.ac.uk/centre-of-ex...

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 28d

Securing the future: Shaping the UK strategy on long-acting therapeutics is a UK Hub for Advanced Long-acting Therapeutics (HALo) event:
📆 6 November
⏰ 10-4 (GMT)
🌍 Liverpool, UK
Speakers represent research, industry, regulators, clinical and more.

Register: www.liverpool.ac.uk/centre-of-ex...

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 29

This week's global updates of other teams' long-acting therapeutics news covers the @ec.europa.eu's approval of Gilead Sciences' yeytuo (lenacapavir), a twice yearly dose HIV PrEP.

Read all about it: www.liverpool.ac.uk/centre-of-ex...

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 28

Are you subscribed to our quarterly #LONGEVITYproject newsletter?

We use it to share news, events and opportunities within our international consortium in our work towards creating long-acting therapeutics for HCV, malaria and TB in LMICs.

Subscribe here: www.liverpool.ac.uk/centre-of-ex...

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 27

Our Teoreler team, a free web-based PBPK modelling app, work hard to update and create new models.

Current models available include;
👥 adult PBPK
🧒 child/adolescent
💊 drug-drug interaction
🐁 mice
🐀 rats

It's in beta, so we'd appreciate feedback from its users: www.liverpool.ac.uk/centre-of-ex...

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 22

This week's global news focuses on Gilead's lenacapavir:

🖋️250+ people / organisations signed a letter from @publiccitizen.bsky.social calling for rapid application for regulatory approval of lenacapavir in LMICs
💻@who.int host a Guidelines on lenacapavir webinar

www.liverpool.ac.uk/centre-of-ex...

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 21

Are you interested in Dr Adeniyi Olagunju's Perinatal Pharmacology team's app, PKRxiv, for data sharing?

For more information about the context of PKRxiv within CELT, follow the link: www.liverpool.ac.uk/centre-of-ex...

An image that says "Data Sharing Models" down the side with three title blocks at the top; unrestricted, non-commercial and contributor controlled.

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 20

For #WorldMosquitoDay, we need your feedback.

In June, @who.int convened the PADO process for malaria.

CELT Co-Director Prof Andrew Owen was part of the meeting, who are calling for experts who aren't part of the work so far to feedback on the proposed priorities.
More: www.who.int/news-room/ar...

Call for public consultation: Paediatric drug optimization for malaria

www.who.int

Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 18

We've updated CELT's Community of Practice for long-acting therapeutics for maternal and paediatric health project page.

It now includes videos from each of the maternal, paediatric and global health sessions at the in-person meeting in July.

Watch them here: www.liverpool.ac.uk/centre-of-ex...

Members of CELT's Community of Practice for long-acting therapeutics for maternal and paediatric health are stood on a raised, bright, airy area of The Spine in Liverpool, smiling at the camera.

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Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 15

We're looking forward to this next month.

CELT are presenting and some #LONGEVITYproject work, funded by @unitaid.bsky.social, is being represented as well.

If you're there, please find us to say hi.

Academic Medical Education @academicmededu.bsky.social · Aug 13

Next stop: Amsterdam!

Counting down the days to the 26th International Workshop on Clinical Pharmacology of HIV, Hepatitis, and Other Antiviral Drugs!

Topics: #pandemic preparedness, #druginteraction, #LongActing for #HCV, #CMVTherapy, and more!

🔗 amededu.co/4hTUPgN

#IDSky #MedSky #ANTIVIRALPK

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Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 14

While CELT is one big team, there are a lot of different disciplines required for what we do.

Find out about the different research groups all working together towards creating long-acting versions of existing medications:
www.liverpool.ac.uk/centre-of-ex...

Members | CELT research groups|Centre of Excellence for Long-acting Therapeutics | Centre of Excellence for Long-acting Therapeutics | University of Liverpool

CELT is made up of members from different disciplines who lead research groups, but our research has a shared goal. Find out about each member and their group here.