We were so thrilled to host kiranmusunuru.bsky.social as part of our Genomic Medicine Seminar Series! It was a day full of productive meetings with colleagues, an exciting hour-long talk on his groundbreaking work in CRISPR-based therapeutics, and a trainee roundtable discussion.

Join us for an exciting CGM seminar today at noon with the Children's Hospital of Pennsylvania's very own kiranmusunuru.bsky.social (also a CGM alum). You don't want to miss it!

Join us for an exciting CGM seminar today at noon with the Children's Hospital of Pennsylvania's very own @kiranmusunuru.bsky.social (also a CGM alum). You don't want to miss it!

Another great seminar this week with Philip A Cole, MD, PhD from BWH Genetics. We're so grateful he came over to give the first of many talks featuring speakers from across our MGB genetics and genomics community.

New work from the Wheeler lab shows DNA repair gene MSH3 modifies disease: variants that boost repeat expansion cause earlier onset, while those promoting contraction delay onset—in blood and brain. Targeting MSH3 could delay or prevent X-Linked Dystonia Parkinsonism (XDP)

Our newest CGM faculty member, @alicestanton.bsky.social, recently published this exciting paper in PNAS titled, "Engineered 3D immuno-glial-neurovascular human miBrain model". The paper describes her innovative work creating the MiBrain platform.

A great kickoff to our spring seminar series! It was an hour of exciting science, brought to us by @bkleinstiver.bsky.social and his lab, @rachelsilverstein9.bsky.social & @connorjtou.bsky.social. Just like Dr. Kleinstiver's slide, we too are thankful 🙏🙏🙏 for the Kleinstiver research group!

New year, new seminar schedule! We are so excited to hear from this stellar group of speakers on Wednesdays. We'll kick off the new semester with CGM PI @bkleinstiver.bsky.social tomorrow. Can't wait to see you there!

Check out this exciting recent work from CGM PI @jorsmo.bsky.social and his colleagues in the @pgcgenetics.bsky.social!

We had such a wonderful time seeing familiar and new faces at our Center’s holiday party this week. We hope everyone enjoyed! Please tag us in your party photos- we love to see our community having fun. Thank you as always to The Liberty Hotel for hosting us!

Don't miss the last CGM Seminar of the semester tomorrow where we'll hear from Raghu Chivukula and his lab! If you can't join us in person, join on zoom here: https://loom.ly/R-Ujl8w

A new multi-ancestry polygenic score for type 1 diabetes improves predictive power in non-European ancestries while maintaining high predictive power in European ancestry. Read this recent paper from Miriam Udler, Aaron Deutsch, and colleagues here!: https://loom.ly/zCRDnQQ #type1diabetes

Don't miss Dr. Andrea Edlow and lab tomorrow at the CGM Seminar! Information below

@cgm-mgh.bsky.social faculty Chris Anderson and team found polygenic risk scores, combined w/ clinical predictors, can help identify patients most likely to develop atrial fibrillation after stroke loom.ly/QQQFp8s

🚨🚨🚨 In collaboration with @pnatarajanmd.bsky.social we are excited to launch gVasc, a new biobank focused on the genetics of spontaneous coronary artery dissection (SCAD)! with a participant-facing enrollment portal,
👉 gvascstudy.org 👈

A special congratulations to Konrad Karczewski, Siwei Chen, @ksamocha.bsky.social and Mike Guo for all their hard work on these publications. Read more about this work at www.nature.com/articles/d41... (2/2)

🚨New paper out in Nature Mental Health from my work with @erindunnscd.bsky.social at #MassGeneral! We found that childhood adversity leads to #epigenetic changes that can increase OR reduce risk for depression. Let me explain... 🧵(1/6)

Read the paper here: www.nature.com/articles/s44...

Researchers @TalkowskiLab used long-read sequencing and the T2T reference to characterize previously intractable genome rearrangements (e.g. ring chroms, Robertsonian translocations), shining light on their formation and consequences. @ajhgnews.bsky.social www.sciencedirect.com/science/arti...