Rimas Orentas
@cgtgaithersburg.bsky.social
Immunotherapy R&D - looking to develop immunotherapy, cell and gene therapy, and make an end to sickle cell disease.
Mid-blowing data #ASH25 from MJ Friedrich -recreating a thymic environment in the liver via LNPs generated young T cell phenotype and this correlates to better response to checkpoint blockade in mouse tumor models and better vaccine responses @technologyreview.com @broadinstitute.org
December 6, 2025 at 9:31 PM
Mid-blowing data #ASH25 from MJ Friedrich -recreating a thymic environment in the liver via LNPs generated young T cell phenotype and this correlates to better response to checkpoint blockade in mouse tumor models and better vaccine responses @technologyreview.com @broadinstitute.org
Michelle Weeks presenting a Master Class in DNA sequencing at #ASH25 of over 4,000 #sicklecelldisease cases showing clonal hematopoiesis starts at infancy and increases to 7.1% by age 11 @danafarber.bsky.social drivers include TP53, ATM, PPMID, CHEK2 @ascaa.bsky.social @conquerscd.bsky.social
December 6, 2025 at 3:07 PM
Michelle Weeks presenting a Master Class in DNA sequencing at #ASH25 of over 4,000 #sicklecelldisease cases showing clonal hematopoiesis starts at infancy and increases to 7.1% by age 11 @danafarber.bsky.social drivers include TP53, ATM, PPMID, CHEK2 @ascaa.bsky.social @conquerscd.bsky.social
Reposted by Rimas Orentas
At one point or another, we're all going to need to see a doctor.
But our health care system remains unaffordable, inaccessible, and deeply dysfunctional. It is unacceptable.
That’s why a strong majority of Americans agree: We need Medicare for All.
But our health care system remains unaffordable, inaccessible, and deeply dysfunctional. It is unacceptable.
That’s why a strong majority of Americans agree: We need Medicare for All.
December 4, 2025 at 9:14 PM
At one point or another, we're all going to need to see a doctor.
But our health care system remains unaffordable, inaccessible, and deeply dysfunctional. It is unacceptable.
That’s why a strong majority of Americans agree: We need Medicare for All.
But our health care system remains unaffordable, inaccessible, and deeply dysfunctional. It is unacceptable.
That’s why a strong majority of Americans agree: We need Medicare for All.
Are you using the right tumor micro environment model? Cancer is a disease of aging @sitcancer.bsky.social #SITC25 great session at the annual meeting on the aged immune system and the tumor micro environment moderated by Drs DA and A Weeraratna.
November 7, 2025 at 9:28 PM
Are you using the right tumor micro environment model? Cancer is a disease of aging @sitcancer.bsky.social #SITC25 great session at the annual meeting on the aged immune system and the tumor micro environment moderated by Drs DA and A Weeraratna.
Great session exploring neuro-immunology in cancer immunotherapy #SITC25. Clearly we have much to learn about this little studied part of tumor biology. U Von Adrian demonstrated how afferent neurons organize and activate MDSCs at the tumor site @sitcancer.bsky.social
November 7, 2025 at 3:44 PM
Great session exploring neuro-immunology in cancer immunotherapy #SITC25. Clearly we have much to learn about this little studied part of tumor biology. U Von Adrian demonstrated how afferent neurons organize and activate MDSCs at the tumor site @sitcancer.bsky.social
Reposted by Rimas Orentas
Excited to present our work at SITC this weekend! Join us on Saturday for Ryma Toumi's poster #796: Engineering T cells to reprogram inhibitory macrophages #SITC2025 #CancerResearch
November 5, 2025 at 6:04 PM
Excited to present our work at SITC this weekend! Join us on Saturday for Ryma Toumi's poster #796: Engineering T cells to reprogram inhibitory macrophages #SITC2025 #CancerResearch
Hill Day @sitcancer.bsky.social sharing our support for the NIH and immunotherapy for cancer w Dr Robyn Gartrell and Andrew Donlon from Rep McClain Delaney’s House Office. Thanks also to staffers from Sen Van Hollen and Alsobrooks office for hosting us as well.
November 5, 2025 at 10:10 PM
Hill Day @sitcancer.bsky.social sharing our support for the NIH and immunotherapy for cancer w Dr Robyn Gartrell and Andrew Donlon from Rep McClain Delaney’s House Office. Thanks also to staffers from Sen Van Hollen and Alsobrooks office for hosting us as well.
Our science at SITC -2 abstracts in the top 150 #Miltenyi #SITC25 #SITC2025 MSLN armored CAR-T (208), PSMA armored CAR-T (228) Spatial proteomics of post Tx sarcoma (243) CD5 CAR-NK (252) BCMA bi-paratopic CAR-T (292) CD276 CAR-T fitness (295) hypoxia expanded NK cells (390) @sitcancer.bsky.social
November 4, 2025 at 8:10 PM
Our science at SITC -2 abstracts in the top 150 #Miltenyi #SITC25 #SITC2025 MSLN armored CAR-T (208), PSMA armored CAR-T (228) Spatial proteomics of post Tx sarcoma (243) CD5 CAR-NK (252) BCMA bi-paratopic CAR-T (292) CD276 CAR-T fitness (295) hypoxia expanded NK cells (390) @sitcancer.bsky.social
Leroy Hood holds forth on the future of genomics and phenomics. Just as we only now have incorporated epigenomics into human biology- there is likely still missing major data sets to allow new advances to come. i e. one proteins can be modified 400 different ways. @systemsbiology.bsky.social
October 28, 2025 at 1:28 AM
Leroy Hood holds forth on the future of genomics and phenomics. Just as we only now have incorporated epigenomics into human biology- there is likely still missing major data sets to allow new advances to come. i e. one proteins can be modified 400 different ways. @systemsbiology.bsky.social
The CAR-T therapy team at Taichung medical center in Taiwan - amazing world class work. This includes new CARs from #Miltenyi, Novartis Tcharge for autoimmune disease and a robust regenerative medicine program
October 25, 2025 at 4:26 AM
The CAR-T therapy team at Taichung medical center in Taiwan - amazing world class work. This includes new CARs from #Miltenyi, Novartis Tcharge for autoimmune disease and a robust regenerative medicine program
#UNGA80 #ECSA East, Central, Southern Africa Session at the UN General Assembly Mtg #ScienceDiplomacy chair Prof Ntobeko Ntusi looking to bridge divides through shared knowledge and establishing regional centers of excellence. We are here to advocate for global health for the UN Pact for the Future
September 26, 2025 at 12:20 PM
#UNGA80 #ECSA East, Central, Southern Africa Session at the UN General Assembly Mtg #ScienceDiplomacy chair Prof Ntobeko Ntusi looking to bridge divides through shared knowledge and establishing regional centers of excellence. We are here to advocate for global health for the UN Pact for the Future
Having visited private and public institutes (view is the medical school at Albert Einstein SOM in São Paulo)- I am inspired by the new approaches for cell and gene therapy. Most of the world has looked at what our “market” has produced and is creating affordable alternatives
August 21, 2025 at 11:44 AM
Having visited private and public institutes (view is the medical school at Albert Einstein SOM in São Paulo)- I am inspired by the new approaches for cell and gene therapy. Most of the world has looked at what our “market” has produced and is creating affordable alternatives
Reposted by Rimas Orentas
No one, at this point, is stupid and venal enough to take the administration up on this - right?
The Trump administration is trying to negotiate with elite universities to strike a "deal." They're feeling the need for a political win after public opinion is in Harvard's corner (much to their surprise).
www.cnn.com/2025/05/31/p...
www.cnn.com/2025/05/31/p...
May 31, 2025 at 2:14 PM
No one, at this point, is stupid and venal enough to take the administration up on this - right?
Dr Hanahan wins the Pezcoller! #AACR25 @theaacr.bsky.social and published today the IL-1 signature of tumors induces systemic immunosuppression_ and is reversed by anti- IL-RAP antibody.
April 27, 2025 at 5:46 PM
Dr Hanahan wins the Pezcoller! #AACR25 @theaacr.bsky.social and published today the IL-1 signature of tumors induces systemic immunosuppression_ and is reversed by anti- IL-RAP antibody.
Wonderful overview today by Ken Anderson @theaacr.bsky.social #AACR25 of the advances in MM- adding CARs to degraders (imids) and blockers (bortezomib) both of which also have immune activity has completely changed the outlook for patients- and that’s why we are here
April 26, 2025 at 11:29 PM
Wonderful overview today by Ken Anderson @theaacr.bsky.social #AACR25 of the advances in MM- adding CARs to degraders (imids) and blockers (bortezomib) both of which also have immune activity has completely changed the outlook for patients- and that’s why we are here
Reposted by Rimas Orentas
We owe him much for his leadership at CBER during a period of remarkable therapeutic advances. The havoc caused by this administration will have a devastating impact for years.
www.washingtonpost.com/politics/202...
www.washingtonpost.com/politics/202...
RFK Jr. forces out Peter Marks, FDA’s top vaccine scientist
Marks, an architect of Operation Warp Speed for coronavirus vaccines, warned that a measles outbreak shows how confidence in science is being “undermined.”
www.washingtonpost.com
March 29, 2025 at 1:53 AM
We owe him much for his leadership at CBER during a period of remarkable therapeutic advances. The havoc caused by this administration will have a devastating impact for years.
www.washingtonpost.com/politics/202...
www.washingtonpost.com/politics/202...
Reposted by Rimas Orentas
At 9 yrs old, my granddaughter was diagnosed with DIPG. It is terminal, usually within 9 months. Because of Dr. Vitanza at Seattle Children’s and clinical trials, we had her mostly symptom free for about 32 months. Make these cuts make sense! I am outraged!
February 24, 2025 at 6:55 PM
At 9 yrs old, my granddaughter was diagnosed with DIPG. It is terminal, usually within 9 months. Because of Dr. Vitanza at Seattle Children’s and clinical trials, we had her mostly symptom free for about 32 months. Make these cuts make sense! I am outraged!
Reposted by Rimas Orentas
Engaging talk by Jen Adair @fredhutch.bsky.social Tandem2025 @astct.bsky.social on efforts to make cell and gene therapy available in low and middle income countries. Academic centers need to step up. Great to see my friend @cgtgaithersburg.bsky.social in the Global Gene Therapy Initiative
February 15, 2025 at 8:03 PM
Engaging talk by Jen Adair @fredhutch.bsky.social Tandem2025 @astct.bsky.social on efforts to make cell and gene therapy available in low and middle income countries. Academic centers need to step up. Great to see my friend @cgtgaithersburg.bsky.social in the Global Gene Therapy Initiative
Dr S Davies from cincinnatichildren’s presents a challenge-using a new vector system and reduced intensity conditioning to keep #sicklecell therapy low cost by keeping the process in academic medical centers & not a strictly high-priced pharma product @ascaa.bsky.social @astct.bsky.social #Tandem25
February 14, 2025 at 7:20 PM
Dr S Davies from cincinnatichildren’s presents a challenge-using a new vector system and reduced intensity conditioning to keep #sicklecell therapy low cost by keeping the process in academic medical centers & not a strictly high-priced pharma product @ascaa.bsky.social @astct.bsky.social #Tandem25
Dr M Bleakly from @fredhutch.bsky.social delivering a master class on using minor antigens to create anti-leukemia T cells in the context of HSCT @astct.bsky.social #Tandem25 incredible analysis of hematologic restricted targets
February 14, 2025 at 3:39 AM
Dr M Bleakly from @fredhutch.bsky.social delivering a master class on using minor antigens to create anti-leukemia T cells in the context of HSCT @astct.bsky.social #Tandem25 incredible analysis of hematologic restricted targets
Dr N Shah from MCW presenting Tandem CD20-19 CAR-T using fresh in/fresh out manufacturing allowing many patients to receive this therapy who otherwise would not qualify @astct.bsky.social #Tandem25
February 14, 2025 at 1:32 AM
Dr N Shah from MCW presenting Tandem CD20-19 CAR-T using fresh in/fresh out manufacturing allowing many patients to receive this therapy who otherwise would not qualify @astct.bsky.social #Tandem25
Reposted by Rimas Orentas
Defend the NIH. timmermanreport.com/2025/02/defe...
Defend the NIH - TimmermanReport.com
Too many people don’t believe anymore in the American Dream. But if you can’t dream big, you can’t accomplish big things. Today, the National Institutes of Health — biomedical science itself — is unde...
timmermanreport.com
February 13, 2025 at 5:04 PM
Defend the NIH. timmermanreport.com/2025/02/defe...
Reposted by Rimas Orentas
Stand Up for Science rallies will be held in DC and state capitals on March 7th. Share with friends. Sign-up here to get email updates with details: www.eventbrite.com/e/stand-up-f...
STAND UP FOR SCIENCE 2025 - DC and NATIONWIDE
Stand up for science with us on March 7th, 2025, because science is for everyone! More info at www.standupforscience2025.org
www.eventbrite.com
February 12, 2025 at 12:44 PM
Stand Up for Science rallies will be held in DC and state capitals on March 7th. Share with friends. Sign-up here to get email updates with details: www.eventbrite.com/e/stand-up-f...
