Grant Challen
@challenlab.bsky.social
Biomedical research team trying to figure out stem cells and blood cancers. Dad, husband, kids soccer coach, rugby enthusiast, everything Star Wars / Marvel.
Check out our new paper describing a previously unexplored relationship between DNMT3A and telomeres. A huge team effort! Comments and new collaborations welcome!
Online Now! Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity #stemcells
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity
Challen and colleagues show that the clonal expansion of Dnmt3a-null HSCs in serial bone marrow transplantation assays is not dependent on the loss of DNA methylation functions of Dnmt3a. They identify non-canonical functions for Dnmt3a in the regulation of telomere length and genome stability that restrict the functional potential of HSCs.
dlvr.it
August 1, 2025 at 5:42 PM
Check out our new paper describing a previously unexplored relationship between DNMT3A and telomeres. A huge team effort! Comments and new collaborations welcome!
Pretty much every mid-40s dude tonight
Let’s go Happy !!
Let’s go Happy !!
July 25, 2025 at 11:51 PM
Pretty much every mid-40s dude tonight
Let’s go Happy !!
Let’s go Happy !!
Reposted by Grant Challen
Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde @lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI
Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis
Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the
frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations
confer a fitness advantag...
bit.ly
May 23, 2025 at 3:04 PM
Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde @lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI
Special guest at lab meeting today thanks @thekinglab.bsky.social !!!
April 25, 2025 at 6:51 PM
Special guest at lab meeting today thanks @thekinglab.bsky.social !!!
Stand up for science!
Trying to get the word out at WashU!
Trying to get the word out at WashU!
March 7, 2025 at 6:15 PM
Stand up for science!
Trying to get the word out at WashU!
Trying to get the word out at WashU!
Believe it or not this is Kansas not Antarctica !!!
January 15, 2025 at 1:05 AM
Believe it or not this is Kansas not Antarctica !!!