Lightnews — Scholar-powered news

Chase Bolt @chasebolt.bsky.social · 2d

The enshitification continues. I'm not even a Conservative, I just think it is fucking stupid to remove a gun from a picture when the 27 movies are just two hours of guns. There is a person in this world that gets paid - probably a shit ton of money - to make these meaningless decisions.

Amazon/MGM removes all guns from James Bond digital posters on Prime

007 is without his Walther PPK on the latest digital posters featured on Prime Video for the James Bond series.

www.joblo.com

Chase Bolt @chasebolt.bsky.social · 2d

Here is a clue, make anything other than a fucking IPA.

Craft Breweries Struggle as Sales and Appetites Wane

www.nytimes.com

Chase Bolt @chasebolt.bsky.social · 17d

Thank you Marian!

Reposted by Chase Bolt

Ars Technica @arstechnica.com · 20d

Distinct digits may have evolved by using DNA that makes the cloaca

Making digits seems to involve gene activity that was needed to make a cloaca.

arstechnica.com

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Chase Bolt @chasebolt.bsky.social · 19d

There is only #babyshark

Chase Bolt @chasebolt.bsky.social · 19d

Thanks Olga!

Chase Bolt @chasebolt.bsky.social · 20d

Thanks Dario!

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Chase Bolt @chasebolt.bsky.social · 20d

Yes they do!

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Chase Bolt @chasebolt.bsky.social · 20d

Thank you Neil!

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Chase Bolt @chasebolt.bsky.social · 20d

Link to the original work (dummy).
www.nature.com/articles/s41...

Co-option of an ancestral cloacal regulatory landscape during digit evolution - Nature

The regulatory landscape controlling Hoxd gene expression in tetrapod digit development was probably co-opted from a pre-existing cloacal regulatory mechanism, as evidenced by the effects of gene...

www.nature.com

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Chase Bolt @chasebolt.bsky.social · 20d

Our work exploring a new explanation for the regulation of Hoxd genes and the #fin-to-limb transition. 🧪

It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social

#evo-devo #InHoxWeTrust

How Did Hands Evolve? The Answer Is Behind You.

www.nytimes.com

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Chase Bolt @chasebolt.bsky.social · 21d

There is a lot of concern about leaked genetic data, but what I wonder is, can a "reputable" legal entity like a health insurance company use this information? Or the government? Wouldn't the chain of custody be unreliable? #genetic #privacy

The precarious future of consumer genetic privacy

Congress and other lawmakers must act to robustly protect direct-to-consumer genetic data and biospecimens into the future

www.science.org

Chase Bolt @chasebolt.bsky.social · 23d

sequence that dude

Chase Bolt @chasebolt.bsky.social · 26d

Merry Crispus!

1

Reposted by Chase Bolt

Alex Stark @alex-stark.bsky.social · 27d

Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!

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Chase Bolt @chasebolt.bsky.social · 27d

"the quest for drug targets have meanwhile reduced much of cancer research from a scholarly biological discipline to a transactional operation concerned more with cataloguing molecular alterations and finding associations, than with understanding fundamental principles using formal theory." Agreed.

The end of the genetic paradigm of cancer

Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...

journals.plos.org

Chase Bolt @chasebolt.bsky.social · 27d

Charlie Kirk is dead by assassination. This political violence needs to stop. Things will only continue to get worse. I didn't like him but no one should be killed for their beliefs and speaking them aloud.

Conservative influencer Charlie Kirk shot dead at Utah event

Kirk, an activist and the founder of conservative student group Turning Point USA, played a key role in driving youth support for Trump in November.

www.reuters.com

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Chase Bolt @chasebolt.bsky.social · 27d

Drivers recruit pioneer factors that then "hop" to near-3D contacts to spread active chromatin context, producing a stable active landscape.

Chase Bolt @chasebolt.bsky.social · 27d

Euchromatin hopping explains how some enhancers seem to initiate the formation of active regulatory landscapes, and why some/many enhancer deletions don't affect transcription quantity; there are driver and passenger enhancers.
#chromatin #enhancers #generegulation

Enhancers mediate euchromatin hopping at chromatin contact points

Enhancer-mediated gene activation involves the recruitment of chromatin modifiers and RNA polymerase to target promoters, but it is unknown if enhancers influence chromatin beyond their target genes. ...

www.biorxiv.org

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Chase Bolt @chasebolt.bsky.social · 28d

As a former #evo-devo academic that moved to industry, I can say that people with evolutionary backgrounds are very employable in #biotech. In fact, they tend to do better than people trained in more narrow topics like cell biology. Folks doing genome evo, please come to industry. We need you.

T. Ryan Gregory 🇨🇦 @tryangregory.bsky.social · 28d

We don't structure our programs to reflect this, but in reality faculty is the alternative career path, not the default.

Richard McElreath 🐈‍⬛ @rmcelreath.bsky.social · 28d

“Overall, the message from this survey is positive; evolutionary biologists are readily employable outside of academia, generally well-prepared for those jobs, and report high levels of satisfaction” www.biorxiv.org/content/10.1...

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Chase Bolt @chasebolt.bsky.social · 29d

Oh that’s already taken by the Fed.

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Reposted by Chase Bolt

Developmental Biology @devbiol.bsky.social · Sep 3

#DBfeature

Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns
by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph
tiom33.short.gy/DB520,155-170

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Chase Bolt @chasebolt.bsky.social · Apr 18

who will republicans blame for their problems when govt no longer exists?

Chase Bolt @chasebolt.bsky.social · Mar 4

@smpowers.bsky.social I found you!

Chase Bolt @chasebolt.bsky.social · Feb 18

Wouldn’t a sufficiently complex system stochastically produce regions of greater complexity?