Chen Wang
@chenwang.bsky.social
Postdoc | UMass Chan Medical School @umasschan.bsky.social | biochemistry & structural biology
PhD | Australian National University | host-microbe interactions
PhD | Australian National University | host-microbe interactions
Reposted by Chen Wang
Online Now: Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity Online now:
Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity
The cryo-EM structure of the retron Eco8 system reveals an autoinhibited 4:4:4 complex of RT, msDNA, and OLD nuclease. Phage SSB binding to msdDNA unleashes non-specific nuclease activity to restrict phage replication, establishing msDNA as a molecular switch for Eco8 activation.
dlvr.it
October 30, 2025 at 7:14 PM
Online Now: Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity Online now:
I’m thrilled to share our Retron Eco8 paper published in Molecular Cell today. Thanks all Fu lab members and our collaborators.
👉Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity. www.cell.com/molecular-ce...
👉Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity. www.cell.com/molecular-ce...
Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity
The cryo-EM structure of the retron Eco8 system reveals an autoinhibited 4:4:4 complex
of RT, msDNA, and OLD nuclease. Phage SSB binding to msdDNA unleashes non-specific
nuclease activity to restrict ...
www.cell.com
October 30, 2025 at 3:06 PM
I’m thrilled to share our Retron Eco8 paper published in Molecular Cell today. Thanks all Fu lab members and our collaborators.
👉Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity. www.cell.com/molecular-ce...
👉Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity. www.cell.com/molecular-ce...
Reposted by Chen Wang
Structural insights into type I and type II Lamassu anti-phage systems https://www.biorxiv.org/content/10.1101/2025.06.23.660979v1
June 24, 2025 at 3:17 AM
Structural insights into type I and type II Lamassu anti-phage systems https://www.biorxiv.org/content/10.1101/2025.06.23.660979v1
Thrilled to share our new paper uncovering the defense mechanism of Retron-Septu antiphage systems! Grateful to the incredible Fu lab team, our outstanding colleagues at UMass Chan and OSU, and wonderful collaborators at UCSD for their support and contributions.
❄️🔬🧬🦠🧫 Disassembly activates Retron-Septu for antiphage defense | Science www.science.org/doi/10.1126/... @rti-umasschan.bsky.social #RNA #DNA #retrons #microbiology #phage #immunity #phagesky #MicroSky
June 16, 2025 at 2:41 PM
Thrilled to share our new paper uncovering the defense mechanism of Retron-Septu antiphage systems! Grateful to the incredible Fu lab team, our outstanding colleagues at UMass Chan and OSU, and wonderful collaborators at UCSD for their support and contributions.
Reposted by Chen Wang
❄️🔬🧬🦠🧫 Disassembly activates Retron-Septu for antiphage defense | Science www.science.org/doi/10.1126/... @rti-umasschan.bsky.social #RNA #DNA #retrons #microbiology #phage #immunity #phagesky #MicroSky
June 16, 2025 at 5:31 AM
❄️🔬🧬🦠🧫 Disassembly activates Retron-Septu for antiphage defense | Science www.science.org/doi/10.1126/... @rti-umasschan.bsky.social #RNA #DNA #retrons #microbiology #phage #immunity #phagesky #MicroSky
Reposted by Chen Wang
Hot off the press from the RTI: Disassembly activates Retron-Septu for antiphage defense
pubmed.ncbi.nlm.nih.gov/40504952/?ut... #RNA #RNATherapeutics
pubmed.ncbi.nlm.nih.gov/40504952/?ut... #RNA #RNATherapeutics
Disassembly activates Retron-Septu for antiphage defense - PubMed
Retrons are antiphage defense systems that produce multicopy single-stranded DNA (msDNA) and hold promises for genome engineering. However, the mechanisms of defense remain unclear. The Retron-Septu system...
pubmed.ncbi.nlm.nih.gov
June 13, 2025 at 5:02 PM
Hot off the press from the RTI: Disassembly activates Retron-Septu for antiphage defense
pubmed.ncbi.nlm.nih.gov/40504952/?ut... #RNA #RNATherapeutics
pubmed.ncbi.nlm.nih.gov/40504952/?ut... #RNA #RNATherapeutics
Reposted by Chen Wang
🧬🧫🦠 @science.org Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense | Science www.science.org/doi/10.1126/... #microbiology #bacteriophage #antiphage #immunity #DNA #RNAsky #RT #Cryo-EM #DRT9
May 2, 2025 at 9:02 PM
🧬🧫🦠 @science.org Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense | Science www.science.org/doi/10.1126/... #microbiology #bacteriophage #antiphage #immunity #DNA #RNAsky #RT #Cryo-EM #DRT9
Reposted by Chen Wang
Excited to share my PhD work in the Kranzusch Lab published in @nature.com!
Two key discoveries:
- Nucleotides can act as negative regulators of antiviral immunity
- Ion channel activation is gated by DNA
Thank you to our all collaborators! @soreklab.bsky.social
www.nature.com/articles/s41...
Two key discoveries:
- Nucleotides can act as negative regulators of antiviral immunity
- Ion channel activation is gated by DNA
Thank you to our all collaborators! @soreklab.bsky.social
www.nature.com/articles/s41...
A DNA-gated molecular guard controls bacterial Hailong anti-phage defence - Nature
Nature - A DNA-gated molecular guard controls bacterial Hailong anti-phage defence
www.nature.com
April 30, 2025 at 6:57 PM
Excited to share my PhD work in the Kranzusch Lab published in @nature.com!
Two key discoveries:
- Nucleotides can act as negative regulators of antiviral immunity
- Ion channel activation is gated by DNA
Thank you to our all collaborators! @soreklab.bsky.social
www.nature.com/articles/s41...
Two key discoveries:
- Nucleotides can act as negative regulators of antiviral immunity
- Ion channel activation is gated by DNA
Thank you to our all collaborators! @soreklab.bsky.social
www.nature.com/articles/s41...
Reposted by Chen Wang
Out in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage
Joint work with the Tamulaitienė and Kranzusch labs
www.nature.com/articles/s41...
Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
Joint work with the Tamulaitienė and Kranzusch labs
www.nature.com/articles/s41...
Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
April 30, 2025 at 6:44 PM
Out in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage
Joint work with the Tamulaitienė and Kranzusch labs
www.nature.com/articles/s41...
Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
Joint work with the Tamulaitienė and Kranzusch labs
www.nature.com/articles/s41...
Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
Reposted by Chen Wang
My lab has postdoc openings in the following areas: 1) Structural biology and single molecule biophysics; 2) Developing novel genome editing methods; and 3) Protein and RNA engineering. Please share the info with your trainees, and RT please. 🙏 postdocs.yale.edu/yale-postdoc...
Yale Postdoctoral Positions
| Office for Postdoctoral Affairs
postdocs.yale.edu
April 22, 2025 at 5:00 PM
My lab has postdoc openings in the following areas: 1) Structural biology and single molecule biophysics; 2) Developing novel genome editing methods; and 3) Protein and RNA engineering. Please share the info with your trainees, and RT please. 🙏 postdocs.yale.edu/yale-postdoc...
Reposted by Chen Wang
Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery https://www.biorxiv.org/content/10.1101/2025.04.02.646746v1
April 2, 2025 at 4:16 PM
Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery https://www.biorxiv.org/content/10.1101/2025.04.02.646746v1
Reposted by Chen Wang
Hello BlueSky! Inaugural post here from the Sternberg Lab. We're excited to share our latest work, in which we teamed up with the @WiedenheftLab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: www.biorxiv.org/content/10.1...
Protein-primed DNA homopolymer synthesis by an antiviral reverse transcriptase
Bacteria defend themselves from viral predation using diverse immune systems, many of which sense and target foreign DNA for degradation. Defense-associated reverse transcriptase (DRT) systems provide...
www.biorxiv.org
March 26, 2025 at 10:13 PM
Hello BlueSky! Inaugural post here from the Sternberg Lab. We're excited to share our latest work, in which we teamed up with the @WiedenheftLab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: www.biorxiv.org/content/10.1...