5/5: This work was made possible by an incredible team including Dr. Fregoso, Manith Atapattu, LuLu Callies, Deja Monet, Amy Leonardson, Lindsay Clark, and Stella Xu. With support from the Hydrocephalus Association and NIH training awards. #NeurodevelopmentalDisorders #SeattleChildrens

4/5: Loss of miR-9-2 causes widespread disruption of gene networks in vascular, choroid plexus, and neuronal cell types of the developing mouse brain. This suggests MIR-9-2 may play an equally important role in human brain development and in the etiology of neurodevelopmental disorders. #SingleCell

3/5: A role for MIR-9-2 in this disorder has been underappreciated because it was thought to be redundant. We show loss of even just one copy of miR-9-2 causes early hemorrhages, enlarged ventricles, and disrupted development in the mouse brain, mirroring features of 5q14.3 Microdeletion Syndrome.

2/5: The microRNA MIR-9-2 is often deleted along with other genes in human 5q14.3 Microdeletion Syndrome, a rare but severe neurodevelopmental disorder with developmental delay, disrupted speech, epilepsy, and frequently with disrupted blood vessels and enlarged brain ventricles.

Saying goodbye is hard! So is interpreting non-coding variants in visual disorders! Luckily, that is the gift that Dr. Leah VandenBosch left us with after a very successful postdoc in the Cherry Lab. Check your own favorite retinal regulatory variants here: genome.ucsc.edu/s/CherryLab/...