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Reposted by Chiosis Lab

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · 2d

📢 Our October issue is now online. Access the full issue 👉 www.cell.com/trends/bioch....

🎨 The cover highlights a Review from @chiosislabmskcc.bsky.social‬ and co on how PTMs reprogram chaperones into epichaperomes.

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Chiosis Lab @chiosislabmskcc.bsky.social · 29d

💡Have you checked out our latest review in @cp-trendsbiochem.bsky.social? Discover how post-translational modifications can convert molecular chaperones into #epichaperomes – stable scaffolds that restructure protein–protein interaction networks in disease #PPI
www.sciencedirect.com/science/arti...

PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease

Recent discoveries reveal that post-translational modifications (PTMs) do more than regulate protein activity – they encode conformational states that…

www.sciencedirect.com

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Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · Sep 4

Out now in @cp-trendsbiochem.bsky.social: "PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease" from @chiosislabmskcc.bsky.social. Learn more ⬇️

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · Aug 28

📝 Online now - the Review "PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease" from @chiosislabmskcc.bsky.social et al.

#ProteinProteinInteractions #ProteinNetworks #ChaperoneReprogramming

Read it here 👉 authors.elsevier.com/sd/article/S...

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Chiosis Lab @chiosislabmskcc.bsky.social · Sep 3

🌟Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @cp-trendsbiochem.bsky.social
#PTMs #HSP90 #epichaperome #PPI #neuroscience @mskcancercenter.bsky.social
doi.org/10.1016/j.ti...

Redirecting

doi.org

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Reposted by Chiosis Lab

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · Aug 28

📝 Online now - the Review "PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease" from @chiosislabmskcc.bsky.social et al.

#ProteinProteinInteractions #ProteinNetworks #ChaperoneReprogramming

Read it here 👉 authors.elsevier.com/sd/article/S...

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Chiosis Lab @chiosislabmskcc.bsky.social · Aug 14

Sahil presented earlier this month at #AAIC2025 in Toronto @alzassociation.bsky.social
This work was supported by BrightFocus & NIH Aging and aims to advance #precisionmedicine in #neurodegeneration through the development of small molecule probes for #epichaperome imaging in #Alzheimers.

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Chiosis Lab @chiosislabmskcc.bsky.social · Apr 25

🧵Have you checked out our recent article in
Current Opinion in Structural Biology? Follow this thread by Chiosis Lab postdoc Souparna Chakrabarty
to learn about the Dysfunctional Protein-Protein Interactome (#dfPPI) - a #chemoproteomic platform www.sciencedirect.com/science/arti... 🧵(1/11)

Introducing dysfunctional Protein-Protein Interactome (dfPPI) – A platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease

Protein-protein interactions (PPIs) play a crucial role in cellular function and disease manifestation, with dysfunctions in PPI networks providing a …

www.sciencedirect.com

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Reposted by Chiosis Lab

Chiosis Lab @chiosislabmskcc.bsky.social · May 7

🧵Follow this thread by Dr. Tanaya Roychowdhury to learn about the intriguing case of #HSP90 - adapted from our recent publication in @natcomms.nature.com (1/8)

#cancer #phosphorylation #epichaperome #conformation #cellstress

www.nature.com/articles/s41...

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications

Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...

www.nature.com

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Chiosis Lab @chiosislabmskcc.bsky.social · May 7

To know more about this strange and intriguing case check out our work linked below (8/8)
#phosphorylation #epichaperome #cancer #conformation #cellstress
www.nature.com/articles/s41...

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications

Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...

www.nature.com

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Chiosis Lab @chiosislabmskcc.bsky.social · May 7

In #cancer, Casein Kinase 2 (CK2) interacts with #HSP90 and puts phosphate groups on Serine 255 and Serine 226 positions of the charged linker region of HSP90 thereby changing its structure or conformation. This dangerous alter ego of HSP90 helps the cancer cells to survive. (7)
#phosphorylation

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Chiosis Lab @chiosislabmskcc.bsky.social · May 7

This switch of HSP90 to "bad" and the formation of the epichaperome makes it so the #epichaperome now aids #cancer. (6)

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Chiosis Lab @chiosislabmskcc.bsky.social · May 7

#Cancer is a multifactorial disease that manifests as a result of chronic cellular stress, a trigger that turns #HSP90 into Mr. Hyde.
Mr. Hyde can now associate with other chaperone protein members and form a gang (high molecular weight assembly) called “epichaperome”. (5)
#epichaperome

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Chiosis Lab @chiosislabmskcc.bsky.social · May 7

In our latest work, now published in
@natcomms.nature.com, we uncover how #HSP90 switches from “good” to “bad” in #cancer. (4)

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Chiosis Lab @chiosislabmskcc.bsky.social · May 7

Heat Shock Protein 90 (HSP90) is a cellular chaperone protein ubiquitously present in human body and is responsible for folding other important proteins in the cell. However, it can exist either as Dr. Jekyll or Mr. Hyde depending on how stressed the cells are. (3) #cellstress #HSP90

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Chiosis Lab @chiosislabmskcc.bsky.social · May 7

Any protein consists of strings of amino acids that fold into distinct different shapes and structures inside the cell depending on the cellular environment. (2)
#proteinstructure #HSP90 #chaperone #cancer #chembio

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Chiosis Lab @chiosislabmskcc.bsky.social · May 7

🧵Follow this thread by Dr. Tanaya Roychowdhury to learn about the intriguing case of #HSP90 - adapted from our recent publication in @natcomms.nature.com (1/8)

#cancer #phosphorylation #epichaperome #conformation #cellstress

www.nature.com/articles/s41...

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications

Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...

www.nature.com

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Chiosis Lab @chiosislabmskcc.bsky.social · Apr 25

🚀 Integrating dfPPI with other omics could reveal comprehensive disease mechanisms, paving the way for groundbreaking discoveries and precision therapeutics across numerous diseases. #MultiOmics #FutureResearch (11/11)

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Chiosis Lab @chiosislabmskcc.bsky.social · Apr 25

🌐 The open-access dfPPI Platform lets researchers worldwide visualize and analyze dfPPI data interactively, empowering researchers with access to cutting-edge proteomics analysis. #OpenScience #Proteomics

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Chiosis Lab @chiosislabmskcc.bsky.social · Apr 25

⚕️dfPPI help identify a hyperconnectivity state—an increased level of protein interactions in tumors, where cells become highly sensitive to therapies enhancing their effectiveness. #PrecisionMedicine #CancerTherapy

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Chiosis Lab @chiosislabmskcc.bsky.social · Apr 25

🔗 Protein connectivity changes detected by dfPPI show minimal correlation with overall protein expression—demonstrating the need to look beyond protein levels to understand true disease biology. #Proteomics #dfPPI

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Chiosis Lab @chiosislabmskcc.bsky.social · Apr 25

🎗️In cancer cells, dfPPI identifies dysfunctional PPIs critical for malignant behavior—offering insights into novel therapeutic vulnerabilities like mitotic network disruptions. #CancerResearch #Therapeutics

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Chiosis Lab @chiosislabmskcc.bsky.social · Apr 25

🧠 In Alzheimer’s research, dfPPI unveiled significant changes in protein connectivity, with extensive losses and gains of interactions, highlighting disrupted pathways crucial for memory. #Alzheimers #Neurodegeneration

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Chiosis Lab @chiosislabmskcc.bsky.social · Apr 25

🖥️ New bioinformatics pipelines now make dfPPI data analytics user-friendly, aiding scientists to map disease-specific protein interactions and pathways without specialized training. #DataScience #Bioinformatics

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Chiosis Lab @chiosislabmskcc.bsky.social · Apr 25

🔍Specialized #ChemicalProbes are central to dfPPI, capturing dysfunctional interactions—trapping thousands of protein interactors, enabling precise identification of disease-driven interactome changes. #MassSpec #Proteomics (4)

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Chiosis Lab @chiosislabmskcc.bsky.social · Apr 25

🎯#dfPPI employs protein complexes that form under stress conditions as biological baits, capturing disease-specific changes in protein interactions within native cellular environment. This improves relevance & accuracy of the findings in biological contexts. #Chemoproteomics (3)

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