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chowdhurylab.bsky.social
Chowdhury Lab
@chowdhurylab.bsky.social
150 followers 130 following 4 posts
The Chowdhury lab at DFCI/Harvard Medical School studies #DSBrepair, #RadiationOncology & #microRNAs as biomarkers. Account managed by lab members.
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chowdhurylab.bsky.social
Chowdhury Lab @chowdhurylab.bsky.social · Sep 2
Congratulations to first authors @susankilgas.bsky.social and Ariana Bratt, as well as to all other authors.
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chowdhurylab.bsky.social
Chowdhury Lab @chowdhurylab.bsky.social · Sep 2
Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...
Pharmacologic interrogation of USP28 cellular function in p53 signaling
Bratt, Kilgas et al. describe the SAR-driven design of CAS-010, a selective USP28 probe, alongside a control compound and an inhibitor-resistant mutant. They show that USP28 inhibition mimics p53 path...
www.cell.com
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Reposted by Chowdhury Lab
susankilgas.bsky.social
Susan Kilgas @susankilgas.bsky.social · Aug 20
🧬 Calling grad students & postdocs in genome stability/oncology: don’t forget to register for the 2026 Gordon Research Seminar runs Feb 28–Mar 1, Ventura, CA. Keynote: @chowdhurylab.bsky.social. Abstracts due Nov 23, 2025. 🔗 Sign up here: www.grc.org/dna-damage-m...
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chowdhurylab.bsky.social
Chowdhury Lab @chowdhurylab.bsky.social · May 23
Thank you!
chowdhurylab.bsky.social
Chowdhury Lab @chowdhurylab.bsky.social · May 22
Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...
www.science.org
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Reposted by Chowdhury Lab
stowersinstitute.bsky.social
Stowers Institute @stowersinstitute.bsky.social · May 14
Thank you to @chowdhurylab.bsky.social (@danafarber.bsky.social) for joining us for a fantastic #WednedsayLectureSeries on "DNA repair mechanisms in the context of cell cycle with implication in #cancer." 🧬 Hosted by the Si Lab. #SciSky #ResearchSky
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Reposted by Chowdhury Lab
genomeiinetwork.bsky.social
GIIN @genomeiinetwork.bsky.social · May 7
A huge thank you to our speakers @kajastelab.bsky.social and Raphael Ceccaldi for their amazing talks and fascinating research at yesterday's webinar!
Our next webinar is on June 3rd featuring @agagambus.bsky.social and @chowdhurylab.bsky.social.
Join our community: docs.google.com/forms/d/e/1F...
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