Chris Lengerich
@chrislengerich.com
How do we make scientists and engineers 100x more productive to solve problems that matter?
This feed is notebook margins - raw research notes to train a science hypothesis AI later.
Final essays go to Context Fund: https://www.reddit.com/r/contextfund
This feed is notebook margins - raw research notes to train a science hypothesis AI later.
Final essays go to Context Fund: https://www.reddit.com/r/contextfund
January 14, 2026 at 8:14 AM
I wrote something like this for Mac 11 years! ago, more for metrics than alerting, but could be a start:
github.com/chrislengeri...
github.com/chrislengeri...
GitHub - chrislengerich/entropy: A simple keystroke counter for Mac to track your time spent thinking vs. time spent doing.
A simple keystroke counter for Mac to track your time spent thinking vs. time spent doing. - chrislengerich/entropy
github.com
January 12, 2026 at 9:52 PM
I wrote something like this for Mac 11 years! ago, more for metrics than alerting, but could be a start:
github.com/chrislengeri...
github.com/chrislengeri...
A lot of economics tends to be 1, with a bit of 3. 2 is just now becoming possible.
December 28, 2025 at 9:24 PM
A lot of economics tends to be 1, with a bit of 3. 2 is just now becoming possible.
3. Ecological (just describe the niches and complex feedback loops that emerge, without imposing a model, wolves of Yellowstone-ish, model-free).
December 28, 2025 at 9:23 PM
3. Ecological (just describe the niches and complex feedback loops that emerge, without imposing a model, wolves of Yellowstone-ish, model-free).
Confused middle = middle section of the bell curve meme:
imgflip.com/memegenerato...
imgflip.com/memegenerato...
Bell Curve Meme Generator - Imgflip
Insanely fast, mobile-friendly meme generator. Make Bell Curve memes or upload your own images to make custom memes
imgflip.com
November 7, 2025 at 4:06 AM
Confused middle = middle section of the bell curve meme:
imgflip.com/memegenerato...
imgflip.com/memegenerato...
Why it took 12 years to get here will never fully understand, but still, we're here now.
September 21, 2025 at 1:00 AM
Why it took 12 years to get here will never fully understand, but still, we're here now.
Also, no excuse anymore to miss important global trends (via universal translation + summarization):
September 3, 2025 at 5:37 AM
Also, no excuse anymore to miss important global trends (via universal translation + summarization):
[3] One of my FE friends from Coursera used to reskin every site he used; easy to do this for the average user now. The web isn't usable by default, like it was a decade ago, but with a couple config changes, it can be.
August 28, 2025 at 5:39 PM
[3] One of my FE friends from Coursera used to reskin every site he used; easy to do this for the average user now. The web isn't usable by default, like it was a decade ago, but with a couple config changes, it can be.
[2] Newsfeed eradicator extension + Brave's block element works well for enforcing a "no newsfeed" policy.
August 28, 2025 at 5:39 PM
[2] Newsfeed eradicator extension + Brave's block element works well for enforcing a "no newsfeed" policy.
[1] One month to Q3 notes!
August 28, 2025 at 5:34 PM
[1] One month to Q3 notes!
So if you leverage fast APIs for creativity and raise <$100M for wetlab verification, you could discover highly defensible windfalls, especially for indications like aging, a market projected to be 4x bigger ($200B annually) than the market for GLP-1 (www.librariesforthefuture.bio/p/tam-aging-...).
$200 Billion in Revenue: How an Aging Drug Will Conquer Pharma
An aging drug is a drug that has been rigorously shown to increase healthy lifespan in people, with emphasis on the ability to extend quality of life. The economics of delivering such value to human h...
www.librariesforthefuture.bio
August 9, 2025 at 11:06 PM
So if you leverage fast APIs for creativity and raise <$100M for wetlab verification, you could discover highly defensible windfalls, especially for indications like aging, a market projected to be 4x bigger ($200B annually) than the market for GLP-1 (www.librariesforthefuture.bio/p/tam-aging-...).