Ooof thanks for the heads up

Macedo and Lee misrepresent what happened during the pandemic and are unable to confront Covid's actual toll, presumably because it undermines their premise. A longer take here w/my colleague Greg Gibson:

joshuasweitz.substack.com/p/revisionis...

Thanks!!

This is just a sampling of Liz's findings in the paper, all of which have important implications for how the earliest stages of interferon induction are regulated. Check it out!!

4. IFN induction is quite sensitive to the presence/absence of MAPK/JNK signaling activity.

Consistent with this, treatment with a selective JNK inhibitor completely blocks IFN induction.

3. Intrinsic ISG expression and expression of factors in the MAPK-JNK-AP1 signaling network correlate with IFN induction potential across multiple distinct datasets. This points towards two factors that distinguish those cell capable of producing IFN in response to stimuli from those that are not.

2. Cell-to-cell variation in IFN induction phenotypes is heritable. Single cell clones exhibited ~1000X range in IFN induction phenotypes and this variation was stably maintained through numerous generations.

1. Most cells (in our system) are fully capable of sensing polyI:C, as indicated by clear nuclear translocation of IRF3 - its just that this is insufficient to induce IFN transcription. Other factors are required.