Ciara Pugh
@ciarapugh.bsky.social
irish | membrane protein enthusiast @ ucph | she/her
Thanks Manjunath! 🫶
December 10, 2025 at 9:23 PM
Thanks Manjunath! 🫶
In this study, we introduce a copolymer, MAASTY, that directly extracts membrane proteins along with their native lipids from the cell membrane, enabling structural studies by cryo-EM without detergents. This is a major step for the study of human membrane proteins in their native lipid environment.
MAASTY: a (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs - Nature Communications
MAASTY, a methacrylic acid–styrene copolymer, enables high-resolution structural determination of human membrane proteins in native nanodiscs, efficiently solubilizing diverse membrane proteins and pr...
www.nature.com
December 10, 2025 at 2:52 PM
In this study, we introduce a copolymer, MAASTY, that directly extracts membrane proteins along with their native lipids from the cell membrane, enabling structural studies by cryo-EM without detergents. This is a major step for the study of human membrane proteins in their native lipid environment.