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Cole Korponay @ckorponay.bsky.social · Aug 27

And yes, sLFO changes in response to drug administration appear to be most directly driven by changes in cerebral blood flow that stem from arousal-related physiological changes (e.g., to breathing and heart rates) attributable to the drug.

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Cole Korponay @ckorponay.bsky.social · Aug 27

Great questions! The sLFO is a non-neuronal component of the global signal (which includes both neuronal and non-neuronal components). If you're interested in getting the cleanest read-out of neuronal signals possible, then regressing out the sLFO is always going to help with that.

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Cole Korponay @ckorponay.bsky.social · Aug 26

An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...)

Extracting the sLFO signal from BOLD data not only sharpens FC estimates..

..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging

Systemic physiological "noise" in fMRI has clinical relevance

Functional magnetic resonance imaging (fMRI) is central to studying neurobiological mechanisms, yet fMRI has limited clinical utility, highlighting the need for novel approaches. We show that a compon...

www.medrxiv.org

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Cole Korponay @ckorponay.bsky.social · Aug 13

How do we focus on the task in front of us amidst emotionally salient distractors?

Our new paper details the numerous cogs churning simultaneously in the brain to stave off "emotion interference" and focus on task goals

www.nature.com/articles/s42...

#neuroimaging #neuroskyence #compneurosky

Disentangling large-scale brain dynamics and their links to behavior during the emotional face matching task - Communications Biology

Tensor independent component analysis reveals the concurrent brain processes at work during emotion interference suppression and how individual differences relate to cognitive fitness.

www.nature.com

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Cole Korponay @ckorponay.bsky.social · Jul 10

What's the take-away?

Measurements of non-cognitive mental health and measurements of brain function during common fMRI tasks have little to do with one another

Akin to cardiac stress tests, more affectively provocative tasks may be needed to evoke🧠activity w/ MH relevance

Cole Korponay @ckorponay.bsky.social · Jul 10

We also found that:

1) Brain data and mental health data sorted subjects into discordant sets of subtypes

2) Subjects' relatively similar evoked brain activity profiles failed to reflect the comparatively diverse set of mental health profiles across subjects

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Cole Korponay @ckorponay.bsky.social · Jul 10

Multi-network based prediction was also only successful for cognition and proc speed.

Importantly, the composite scores used for each MH domain all had high measurement reliability and similar interindividual variability.

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Cole Korponay @ckorponay.bsky.social · Jul 10

Across all 77 networks, none robustly or reproducibly encoded #WellBeing, #Internalizing or #SubstanceUse, even during tasks w/ socioemotional content.

Instead,🧠network activity near-exclusively encoded individual differences in #cognition across all paradigms.

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Cole Korponay @ckorponay.bsky.social · Jul 10

In our new paper, we searched for markers of normative MH variability in all the evoked🧠networks we could find across a slew of fMRI paradigms w/ putative MH relevance

(We've released maps of all 77 networks in a new "Task-Evoked Network Atlas"): identifiers.org/neurovault.c...

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Cole Korponay @ckorponay.bsky.social · Jul 10

#MentalHealth status is written somewhere in #Brain activity

But even in today’s most marvelously modeled, spotlessly cleaned🧠data, the writing is barely legible

Why? Perhaps,🧠activity evoked by typical🧠scanning conditions just has little MH info🧵

biorxiv.org/content/10.1...

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Cole Korponay @ckorponay.bsky.social · Jul 10

Multi-network based prediction was also only successful for cognition and proc speed.

Importantly, the composite scores used for each MH domain all had high measurement reliability and similar interindividual variability.

Cole Korponay @ckorponay.bsky.social · Jul 10

Across all 77 networks, none robustly or reproducibly encoded #WellBeing, #Internalizing or #SubstanceUse, even during tasks w/ socioemotional content.

Instead,🧠network activity near-exclusively encoded individual differences in #cognition across all paradigms.

1

Cole Korponay @ckorponay.bsky.social · Jul 10

In our new paper, we searched for markers of normative MH variability in all the evoked🧠networks we could find across a slew of fMRI paradigms w/ putative MH relevance

(We've released maps of all 77 networks in a new "Task-Evoked Network Atlas"): identifiers.org/neurovault.c...

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Cole Korponay @ckorponay.bsky.social · May 27

And it's not to pick on you guys or this paper - I know your group does fantastic, super high-quality work. It's just because this confound becomes especially pernicious in arousal change manipulations. I'll leave things there, but again happy to help if want to check this out in your PIDT sample

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Cole Korponay @ckorponay.bsky.social · May 27

Yes, pro physio signals (sLFO a physio signal too, detectable w/ finger pulse oximeter). But our core disagreement isn't about classic physio signals vs sLFO signal, it's about need to model these signals with their regional heterogeneity in mind (see tinyurl.com/442m7hnj); that's key of Riptide

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