Jose Clemente
@clemelab.bsky.social
Mount Sinai | Microbiome | Genetics & Genomics | Immunology
This has been known for some time, although it's a good reminder. A previous study that comes to mind (www.nature.com/articles/nbt...) found most of the variation was due to extraction methods, while the bioinformatics analysis had a smaller effect.
November 16, 2025 at 2:07 PM
This has been known for some time, although it's a good reminder. A previous study that comes to mind (www.nature.com/articles/nbt...) found most of the variation was due to extraction methods, while the bioinformatics analysis had a smaller effect.
Kudos to everybody in the papers for their hard work and contributions. We are so fortunate to work with such an outstanding group of colleagues and friends!
October 16, 2025 at 3:42 PM
Kudos to everybody in the papers for their hard work and contributions. We are so fortunate to work with such an outstanding group of colleagues and friends!
The second study was an anti-inflammatory dietary intervention in osteoarthritis. Responders had significant differences in microbiome and metabolome, and taxa within the Lachnospiraceae were associated with pain reduction and anti-inflammatory metabolite production.
www.mdpi.com/2072-6643/17...
www.mdpi.com/2072-6643/17...
www.mdpi.com
October 16, 2025 at 3:42 PM
The second study was an anti-inflammatory dietary intervention in osteoarthritis. Responders had significant differences in microbiome and metabolome, and taxa within the Lachnospiraceae were associated with pain reduction and anti-inflammatory metabolite production.
www.mdpi.com/2072-6643/17...
www.mdpi.com/2072-6643/17...
The first work studied two different cohorts (US, UK) of monozygotic twins who were discordant for rheumatoid arthritis. Affected twins had a decrease in SCFA producers in both populations, and lower concentration of butyrate, propionate and acetate.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Short-chain fatty acids and their gut microbial pathways distinguish rheumatoid arthritis in discordant monozygotic twins
Although genetic risk factors, such as HLA-DRB1 alleles, contribute to the pathogenesis of rheumatoid arthritis (RA), the concordance rate in monozygo…
www.sciencedirect.com
October 16, 2025 at 3:42 PM
The first work studied two different cohorts (US, UK) of monozygotic twins who were discordant for rheumatoid arthritis. Affected twins had a decrease in SCFA producers in both populations, and lower concentration of butyrate, propionate and acetate.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Very nice paper Noah, congratulations. Hope all is well in Boulder!
October 10, 2025 at 4:06 PM
Very nice paper Noah, congratulations. Hope all is well in Boulder!