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Reposted by Chris McGinnis

Metastasis Research Society @metastasisresearch.bsky.social · Aug 25

🚨Excited for the 2nd MRS Early Career Research Virtual Meeting on Nov 18-19, 2025!

Trainees & Junior Faculty (within 3 years of starting your lab), share your work!
Abstract Deadline: Sept 12, 2025. Submit here: bit.ly/47KLyp2

❗Free registration for MRS Members! #MRS #Research #EarlyCareer

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Liana Lareau @lianafaye.bsky.social · Aug 7

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

Protein language models reveal evolutionary constraints on synonymous codon choice

Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...

www.biorxiv.org

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Chrystal Paulos @chrystalpaulos.bsky.social · Jul 25

🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back.
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!

Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity

Cole et al. report that adoptively transferred, tumor-specific Th17 cells engage host B cells and drive B cell proliferation and differentiation. These Th17 cells require B cells for sustained immunit...

www.cell.com

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Ronan Chaligné @ronanchaligne.bsky.social · Jun 23

🚨🚨 We're hiring! 🚨🚨
The Single-cell Analytics Innovation Lab (SAIL) at @mskcancercenter.bsky.social is looking for a Junior Technician to join our wet lab team!
You'll work with spatial genomics and single-cell technologies, helping us push the boundaries of cutting-edge analysis in cancer research.

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Terkild Brink Buus @terkild.bsky.social · Jun 19

❗How can a cancer exploit its environment and still resist treatment?
✅The answer: co-existing malignant subclones.

Let me walk you through our latest study investigating how divergent evolution drives adaptability, aggressiveness, and drug resistance of T cell cancer. 1/🧵

doi.org/10.1158/2159...

Schematic figure showing divergent evolution of malignant subclones and how they migrate to different tissue compartments (blood vs skin), respond differently to extrinsic stimuli such as Staphylococcus aureus enterotoxins, and how subclones differ in their intrinsic resistance to anti-cancer drugs.

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Juliane Winkler @jwinkler.bsky.social · Jun 2

Genomics fellows - ever wondered what to do with histopathology (e.g. H&E slides)? 🔬➕🧬🟰🤩 I am super excited to have contributed with @evachrenkova.bsky.social to this amazing effort of @andre-rendeiro.com & @yimin-zheng.bsky.social for multimodal data integration: LazySlide!🧵👇

Andre Rendeiro @andre-rendeiro.com · Jun 1

🔬 Whole slide histopathology images are a goldmine for tissue biology and diagnostics - but too often locked away in inaccessible formats or tools. In our new preprint, we introduce LazySlide: an open-source, modular, and interoperable framework.
www.biorxiv.org/content/10.1...

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Metastasis Research Society @metastasisresearch.bsky.social · Jun 3

Register for our next ECLC webinar by Marco Montagner, PhD on Understanding the determinants of the invisible phase of metastasis - June 26th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - tinyurl.com/ujer8yw8

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James Gagnon @james-gagnon.bsky.social · Jun 2

To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals.

For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.

www.biorxiv.org/content/10.1...

MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos

Pooled perturbation screens can reveal cellular regulatory networks, yet scaling these techniques for large-scale screens in animals remains challenging. To address this, we developed MIC-Drop-seq, wh...

www.biorxiv.org

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The Elowitz Lab at Caltech @elowitzlab.bsky.social · Jun 3

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
www.biorxiv.org/content/10.1...

www.biorxiv.org

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Jeremy Berg @jeremymberg.bsky.social · May 23

Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn.

I felt I had to interrupt to respond...

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Metastasis Research Society @metastasisresearch.bsky.social · May 20

Meet the MRS presidents! Dr. Dihua Yu is the Hubert L. & Olive Stringer Chair of Molecular and Cellular Oncology @mdanderson.bsky.social and served as the Metastasis Research Society’s president from 2018-2020.
We interviewed Dr Yu about her research and involvement with the society 🧵…

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Mara Sherman @marasherman.bsky.social · May 14

Congratulations to the brilliant Boire and Pe’er labs plus all authors for this seminal study of the unique tumor immunology of the leptomeninges! ✨

danapeer.bsky.social @danapeer.bsky.social · May 14

I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature

Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

www.nature.com

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Metastasis Research Society @metastasisresearch.bsky.social · May 12

Don't miss the next ECLC webinar by Christine Desmedt, PhD on Opportunities of post-mortem tissue donation programs to advance metastatic cancer research - May 19th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - Register here lnkd.in/gfJKJ_RT...

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Metastasis Research Society @metastasisresearch.bsky.social · May 2

Don't miss the next ECLC webinar by Christine Desmedt, PhD on Opportunities of post-mortem tissue donation programs to advance metastatic cancer research - May 19th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - Register here us02web.zoom.us/webinar/regi...

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Cancer Research UK Manchester Institute @cruk-mi.bsky.social · May 1

New publication in @cp-cancercell.bsky.social from our Skin Cancer and Ageing group led by Dr Amaya Viros, with first author Shilpa Gurung explains the question of age-related #metastasis in #melanoma

For a full-write up & link to #CancerCell paper here:

www.cruk.manchester.ac.uk/news/institu...

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Yardena Samuels @yardenasamuels.bsky.social · Apr 29

Thank you AACR25 for inviting me to give a plenary talk this morning! An absolute honor!

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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · Apr 29

Multi-cellular phenotypic dynamics during the progression of breast tumors https://www.biorxiv.org/content/10.1101/2025.04.16.649085v1

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Flora Rutaganira @frutag33.bsky.social · Apr 21

Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

Flyer for the 2025 Next Generation Faculty Symposium (including QR code in top right corner). This symposium highlights the work of exceptional early-career scientists in the broad field of quantitative biological and biomedical sciences, with a track record of excellence in research, leadership, mentorship, and community engagement. These early career scientists are preparing to launch a faculty search. Applications are due May 30th, 2025.

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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · Apr 18

Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor Dormancy https://www.biorxiv.org/content/10.1101/2025.04.16.649000v1

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Chris McGinnis @cmcginnis.bsky.social · Apr 8

Catch the @metastasisresearch.bsky.social webinar with Dr. Casanova-Acebes — in ~1hr!!

Metastasis Research Society @metastasisresearch.bsky.social · Apr 7

Don't miss out on our next webinar as Dr. Maria Casanova-Acebes @casanova-acebes.bsky.social @cniostopcancer.bsky.social discusses her work on "TREM1-ing-metastasis lung immunity" - April 8th - 10:00 EST | 16:00 CET | 00:00 AEDT

Sign-up today! us02web.zoom.us/webinar/register/WN_tVSpK...

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Chris McGinnis @cmcginnis.bsky.social · Apr 7

check out Daphne's (@dasuperville.bsky.social) updated DECIPHER-seq package for compatibility with Seurat v5 -- extremely useful for analyzing multi-sample sc omics datasets

Daphne Superville @dasuperville.bsky.social · Apr 7

Running NMF on your scRNAseq data? Check out my updates to Lyndsay Murrow's DECIPHER-seq package, now compatible with Seurat v5 objects and rliger v2! github.com/dasuperville...

GitHub - dasuperville/DECIPHER-seq-v2: Data and code to reproduce results from DECIPHER-seq paper. Updated for use with Seurat v5 objects and rLiger v2.

Data and code to reproduce results from DECIPHER-seq paper. Updated for use with Seurat v5 objects and rLiger v2. - dasuperville/DECIPHER-seq-v2

github.com

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Juliane Winkler @jwinkler.bsky.social · Apr 7

🌟 Exciting #PhD Opportunity! Join my lab in beautiful #Vienna. We are studying tumor-immune interactions in #metastasis using #singlecell and #spatial omics! ⏰ Apply by 04/25 bit.ly/3l7WMhs more infos 👉 winklerlab.org

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Chris McGinnis @cmcginnis.bsky.social · Mar 29

With great collaborators @wellerchen.bsky.social @yardenasamuels.bsky.social and many others!

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Chris McGinnis @cmcginnis.bsky.social · Mar 28

same here for K99/R00

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Chris McGinnis @cmcginnis.bsky.social · Mar 28

Love visualizing obesity gradient by just progressively widening the clip art

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