Colm Ryan
colmr.bsky.social
Colm Ryan
@colmr.bsky.social
Systems biology | Bioinformatics | Cancer | Genetic interactions
https://cancerdata.ucd.ie/
(he / him)
yay! top of the to-read pile for January!
December 22, 2025 at 9:05 AM
I've come to the realisation that if I don't have time to review a paper when the request comes in, I probably won't have time to review it in 2 weeks either. The imaginary less busy future never seems to arrive within 2 weeks. Therefore I should accept and review within a few days or decline.
October 17, 2025 at 10:42 AM
We think this work will be useful for 1) those choosing an existing method to score a genetic interaction screen and 2) those developing new genetic interaction scoring systems as it provides a framework for benchmarking. Thanks to @researchireland.ie for funding!
September 29, 2025 at 4:11 PM
We find that no single method performs best across all screens, but one (Gemini) performs well across most and has an available R package (Gemini).
September 29, 2025 at 4:11 PM
1) we develop a benchmark that allow us to compare the performance of different scoring methods when applied to a single screen and 2) we systematically apply this benchmark to 5 scoring methods applied across 5 published screens.
September 29, 2025 at 4:11 PM
Multiple methods for scoring genetic interactions from combinatorial screens have been published, but comparison across methods has been limited. Most published screens use distinct scoring methods, making comparison across published work difficult. Here we make two contributions....
September 29, 2025 at 4:11 PM