cortesmalaria.bsky.social
CortesMalaria Lab
@cortesmalaria.bsky.social
96 followers 67 following 8 posts
Scientists passionate about understanding #epigenetic and #transcriptional processes in #malaria #parasites. We also like #gametocytes! https://cortesmalarialab.wordpress.com/
cortesmalarialab.wordpress.com
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cortesmalaria.bsky.social
CortesMalaria Lab @cortesmalaria.bsky.social · Jul 3
Double congratulations!
cortesmalaria.bsky.social
CortesMalaria Lab @cortesmalaria.bsky.social · Jun 3
🧬We also show that maintenance of heterochromatin at the ap2-g locus depends on the sequences from the putative ap2-g promoter. ▶️Go ahead and take a look! You'll find more juicy details in the paper!! 🤗
cortesmalaria.bsky.social
CortesMalaria Lab @cortesmalaria.bsky.social · Jun 3
Heterochromatin formation is very efficient at var upstream sequences, but it is inefficient for ap2-g 5'CDS sequences, which require looooong DNA sequences and only occurs in a few parasites. Other sequences tested cannot nucleate heterochromatin formation at all! 🤪
a brown dog is sitting on a blanket and looking at the camera with the words `` wait what ? ''
ALT: a brown dog is sitting on a blanket and looking at the camera with the words `` wait what ? ''
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CortesMalaria Lab @cortesmalaria.bsky.social · Jun 3
💡We found that DNA sequences of genes such as ap2-g or var are sufficient to trigger heterochromatin formation when integrated in an euchromatic locus 😯
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CortesMalaria Lab @cortesmalaria.bsky.social · Jun 3
📣Rush to read our latest paper!! journals.plos.org/plospathogen.... You'll learn why #heterochromatin is formed and maintained in specific regions of the Plasmodium falciparum genome and not others 🧵⬇️
Heterochromatin de novo formation and maintenance in Plasmodium falciparum
Author summary Proper regulation of gene expression is crucial for the functioning of all organisms. One key mechanism involves modifications in the structure of chromatin, the DNA and proteins comple...
journals.plos.org
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cortesmalaria.bsky.social
CortesMalaria Lab @cortesmalaria.bsky.social · Mar 4
Our colleagues and us have been abducted from the lab!!! 🆘👽 If you see these ISGlobaliens around Barcelona, don't be shy and ask for a ride in their fantastic UFO! 🤩🛸
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cortesmalaria.bsky.social
CortesMalaria Lab @cortesmalaria.bsky.social · Jan 30
📣📣See our new preprint in Biorxiv, in which we explore the role of the primary DNA sequence 🧬 in de novo heterochromatin formation and maintenance 🔍📊🧩
www.biorxiv.org/content/10.1...
Heterochromatin de novo formation and maintenance in P. falciparum
In the malaria parasite Plasmodium falciparum, the expression of many genes is regulated by heterochromatin (HC) based on the histone mark tri-methylation of histone H3 lysine 9 (H3K9me3). HC assembly...
www.biorxiv.org
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cortesmalaria.bsky.social
CortesMalaria Lab @cortesmalaria.bsky.social · Jan 24
Welcome to our new Bluesky account!!👋😊Lots of science and fun ahead! 🔬🧪🥼🤩
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