カナダ・バンクーバーでフィリピン系住民の伝統を祝うストリートフェスティバルの現場に車が突っ込んだ事件で、少なくとも１１人が死亡したほか数十人が負傷した。警察は今回の事件について、バンクーバー市にとって「最も暗い日」と呼んだ。

Harvard scientist Kseniia Petrova has been in ICE custody for about two months. Her colleague and friend Leon Peshkin says her case is causing some scientists to reconsider working in the U.S.

The offer, which caused President Trump’s memecoin to surge in price, was his family’s latest effort to profit from cryptocurrencies.

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Alexander Smirnov, whose case is now under review by Trump’s Justice Department, had a stake in the firm that lost out to Truth Social in the rush to launch a Trump-branded platform.

Harnessing the power of immune system to treat cancer has become a core clinical approach. However, rewiring of intrinsic circuitry by genomic alterations enables tumor cells to escape immune surveillance, leading to therapeutic failure. Uncovering the molecular basis of how tumor mutations induce therapeutic resistance may guide the development of intervention approaches to advance precision immunotherapy. Here we report the identification of the Liver Kinase B1 (LKB1)-Inhibitor of Apoptosis Protein (IAP)- Janus Kinase 1 (JAK1) dynamic complex as a molecular determinant for immune response of LKB1-mut lung cancer cells. LKB1 alteration exposes a critical dependency of lung cancer cells on IAP for their immune resistance. Indeed, pharmacological inhibition of IAP re-establishes JAK1-regulated Stimulator of interferon genes (STING) expression and DNA sensing signaling, enhances cytotoxic immune cell infiltration, and augmentes immune-dependent anti-tumor activity in an LKB1-mutant immun

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“We need to determine very quickly now, and I’m talking about a matter of days, whether or not this is doable in the next few weeks,” the secretary of state told reporters.