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Cell Host & Microbe

@cp-cellhostmicrobe.bsky.social

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The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.

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Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 2h

Our October issue is live—rooted in strong microbiology and growing insights.

With cover art highlighting the gut-brain axis and work from @katesadlerphd.bsky.social
www.cell.com/cell-host-mi...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 6m

Featured Article: Mycorrhizal networks facilitate resistance:

Transfer of jasmonic acid via mycorrhizal networks from B.cinerea-infected to healthy plants induces shifts in root exudates that recruit disease-suppressive bacteria to rhizosphere, yielding resistance
www.cell.com/cell-host-mi...

Common mycorrhizal networks facilitate plant disease resistance by altering rhizosphere microbiome assembly

Common mycorrhizal networks (CMNs) facilitate chemical communication between plants. Zhang et al. demonstrate the transfer of jasmonic acid via CMN from Botrytis cinerea-infected donor plants to healt...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 1h

Inter-kingdom lipid messengers sustain gut harmony

Preview of work revealing uLCFAs accumulate in gut upon immune activation. Blautia ohyA converts uLCFAs into non-toxic hydroxy FAs that suppress pro-inflammatory T cells, thereby regulating immunostasis
www.cell.com/cell-host-mi...

Inter-kingdom lipid messengers sustain gut harmony

In this issue of Cell Host & Microbe, Czauderna et al. reveal that unsaturated long-chain fatty acids (uLCFAs) accumulate in the gut during immune activation, yet are toxic to commensals, notably Blau...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 1h

Featured Article: uLCFAs in host-microbe crosstalk

Immune responses trigger release of unsaturated long-chain fatty acids (uLCFAs) in gut, reprogramming bacteria, ie Blautia. Blaudia ohyA converts toxic uLCFAs to hydroxy-FAs w/immunomodulatory effects
www.cell.com/cell-host-mi...

Long-chain unsaturated fatty acids released during immune responses stimulate host-microbe trans-kingdom communication

Czauderna et al. report that immune responses stimulate the release of dietary-like fatty acids in the gut, reprogramming beneficial bacteria such as Blautia to produce anti-inflammatory molecules. Th...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 2h

Our October issue is live—rooted in strong microbiology and growing insights.

With cover art highlighting the gut-brain axis and work from @katesadlerphd.bsky.social
www.cell.com/cell-host-mi...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 22h

Molecular mechanisms of host-microbiome interactions:

We teamed up w/ @cp-cellchembiol.bsky.social for a Collection of articles uncovering mechanisms by which microbes communicate w/their hosts, shedding light on various conditions & offering therapeutic avenues.Enjoy!
www.cell.com/cp/collectio...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 23h

Cadaverine rewires macrophages:

Gut-microbiota-derived cadaverine reprograms macrophage energy metabolism, altering inflammatory immunophenotypes. In IBD, cadaverine is associated w/increased flare risk & regulated by Enterobacteriaceae

www.cell.com/cell-host-mi...

Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation

de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms macrophage energy metabolism in a concentration-dependent fashion, promoting either anti- or pro-inflammatory immun...

Reposted by Cell Host & Microbe

Ivan Zanoni @lozanzi.bsky.social · 4d

#WeekendRead! #ImmunometabolismPower! Formiga, Sokol &co show @cp-cellhostmicrobe.bsky.social that #microbiota derived cadaverine 🧟‍♂️ controls macrophage metabolism & gut inflammation. Low 🧟‍♂️ activates NRF2 promoting OXPHOS & homeostasis, while high 🧟‍♂️ drives glycolysis & intestinal inflammation 🔥 !!

Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation

de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms macrophage energy metabolism in a concentration-dependent fashion, promoting either anti- or pro-inflammatory immun...

Reposted by Cell Host & Microbe

eislmayrk.bsky.social @eislmayrk.bsky.social · 7d

Thrilled to see our paper published!
Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ.
A huge thank you to everyone involved!
@cp-cellhostmicrobe.bsky.social @ucberkeleyofficial.bsky.social

www.cell.com/cell-host-mi...

Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ

Eislmayr et al. reveal a previously unrecognized role of macrophages in controlling the intracellular pathogen Shigella. By sensing bacteria and triggering IFN-γ production, macrophages, not neutrophi...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 8d

B. fragilis protease cuts through the pain

Bacteroides fragilis protease Bfp1 cleaves and activates PAR2, disrupting intestinal barrier function, sensitizing nociceptors, and triggering inflammation and pain
www.cell.com/cell-host-mi...

A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation

Lakemeyer and colleagues analyze the secretome of gut bacteria to identify factors that target host PAR2. They find that the Bacteroides fragilis protease Bfp1 cleaves and activates PAR2, disrupting i...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 8d

Microbiota extends reproductive lifespan:

Germ-free female mice undergo accelerated primordial follicle loss & reduced reproductive capacity that are restored upon post-natal colonization. Microbial SCFAs & fiber mitigates ovarian dysfunction
www.cell.com/cell-host-mi...

The microbiota extends the reproductive lifespan of mice by safeguarding the ovarian reserve

Munyoki et al. demonstrate that gut microbiota extend the female reproductive lifespan by safeguarding the ovarian reserve. Germ-free mice undergo accelerated primordial follicle loss and reduced repr...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 9d

Bacteria enhance sulfur deficiency tolerance in plants

Rhizosphere microbiome is remodeled under sulfur (S) deficiency with competition among bacteria increasing their release of glutathione, which benefits the plant at expense of bacterial fitness
www.cell.com/cell-host-mi...

A bacterial signal coordinates plant-microbe fitness trade-off to enhance sulfur deficiency tolerance in plants

Mukherjee et al. report fitness trade-off between plants and the rhizosphere microbiome under sulfur deficiency, mediated by the tri-peptide signal glutathione. Competition among rhizosphere bacteria ...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 16d

uLCFAs in host-microbe crosstalk:

Immune responses trigger release of unsaturated long-chain fatty acids (uLCFAs) in gut, reprogramming bacteria, ie Blautia. Blaudia ohyA converts toxic uLCFAs to hydroxy-FAs w/immunomodulatory effects

www.cell.com/cell-host-mi...

Long-chain unsaturated fatty acids released during immune responses stimulate host-microbe trans-kingdom communication

Czauderna et al. report that immune responses stimulate the release of dietary-like fatty acids in the gut, reprogramming beneficial bacteria such as Blautia to produce anti-inflammatory molecules. Th...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 19d

Restoring fungal resistance in rice:

New work identifies STOM, a fungal MAMP, and its receptor-co-receptor pair, STOMR/STOMRh. Evolutionary loss of functional STOMRh in monocots restricts immune recognition, while restoring it in rice reconstitutes defense
www.cell.com/cell-host-mi...

Fungal resistance in rice is restored by interfamily transfer of an evolutionarily lost co-receptor

Zhang et al. identify STOM, a previously unknown fungal MAMP, and its receptor-co-receptor pair, STOMR/STOMRh. The evolutionary loss of functional STOMRh in monocots restricts immune recognition, whil...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 20d

Microbiota-derived indole sulfate promotes heart failure in CKD:

E. coli-derived indoxyl sulfate promotes heart failure progression in chronic kidney disease via AHR-CYP1B1. Targeting microbiota-indoxyl sulfate pathway offers therapeutic potential
www.cell.com/cell-host-mi...

Gut-microbiota-derived indole sulfate promotes heart failure in chronic kidney disease

Heart failure (HF) is highly prevalent among patients with chronic kidney disease (CKD), yet the exact mechanisms remain unclear. Zhang et al. demonstrate that E. coli-derived indoxyl sulfate promotes...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 20d

Mycorrhizal networks facilitate plant resistance:

Transfer of jasmonic acid via mycorrhizal networks from B.cinerea-infected to healthy plants induces shifts in root exudates that recruit disease-suppressive bacteria in receiver rhizosphere, yielding resistance
www.cell.com/cell-host-mi...

Common mycorrhizal networks facilitate plant disease resistance by altering rhizosphere microbiome assembly

Common mycorrhizal networks (CMNs) facilitate chemical communication between plants. Zhang et al. demonstrate the transfer of jasmonic acid via CMN from Botrytis cinerea-infected donor plants to healt...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 21d

Microbiota drives sickle cell disease pain

Sickle cell disease mice have excessive heme catabolites, fewer bacteria metabolizing bilirubin & low A. muciniphila. A. muciniphila or TRPM2 inhibitors (blocking bilirubin signals) reduce SCD pain

@katesadlerphd.bsky.social
www.cell.com/cell-host-mi...

Gut microbiota and metabolites drive chronic sickle cell disease pain in mice

Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 23d

All systems go: CRISPR crosstalk for enhanced immunity

Barrangou Previews papers led by @peterfineran.bsky.social & Meeske demonstrating CRISPR-Cas systems have unprecedented level of cooperative crosstalk between different subtypes, enabling primed spacer acquisition
www.cell.com/cell-host-mi...

All systems go: CRISPR crosstalk for enhanced immunity

In this issue of Cell Host & Microbe, companion manuscripts from Margolis & Meeske and Smith & Fineran demonstrate that CRISPR-Cas systems have an unprecedented level of cooperative crosstalk between ...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 23d

Type I CRISPR-Cas immunity primes type III spacer acquisition

Priming by type I CRISPR-Cas aids spacer maintenance by co-occurring type III. Concurrent DNA&RNA-targeting minimize phage escape for population benefit

@peterfineran.bsky.social @leahmsmith.bsky.social
www.cell.com/cell-host-mi...

Type I CRISPR-Cas immunity primes type III spacer acquisition

Smith and Fineran describe how priming by type I CRISPR-Cas systems facilitates adaptation and spacer maintenance by a co-occurring type III system, which normally induces abortive infection. While ty...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 23d

CRISPR-Cas Crosstalk

Margolis & Meeske show RNA-targeting CRISPR-Cas13 system acquires immunological memory in native host L. seeligeri using machinery of 2 co-occurring CRISPR types, which work together to acquire DNA fragments from invading phages
www.cell.com/cell-host-mi...

Crosstalk between three CRISPR-Cas types enables primed type VI-A adaptation in Listeria seeligeri

Margolis et al. describe a mechanism by which the RNA-targeting CRISPR-Cas13 system acquires new immunological memories in its native host Listeria seeligeri. The system relies on the machinery of two...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 26d

Macrophages take center stage in shigellosis

In mouse model of shigellosis, macrophages (not neutrophils) are key to controlling Shigella. Macrophages sense Shigella via TLRs to produce IL-12, which induces IFN-γ to help epithelial cells fight infection
www.cell.com/cell-host-mi...

Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ

Eislmayr et al. reveal a previously unrecognized role of macrophages in controlling the intracellular pathogen Shigella. By sensing bacteria and triggering IFN-γ production, macrophages, not neutrophi...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 26d

Veillonella gives C. diff a jump start

Oral commensal Veillonella promotes C. difficile germination by disrupting bile acid recycling. Veillonella LPS activates signaling to suppress BA transporter, preventing bile acid reabsorption
www.cell.com/cell-host-mi...

Veillonella intestinal colonization promotes C. difficile infection in Crohn’s disease

Yang et al. identify the oral commensal Veillonella as a key driver of Clostridioides difficile infection in Crohn’s disease. Veillonella promotes pathogen germination by disrupting bile acid recyclin...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 27d

Global currents, microbial footprints

Preview of @bethanykolody.bsky.social & Allen & @banfieldlab.bsky.social work integrating oceanographic measurements w/molecular sampling to show hydrographic features shape microbial functional landscape
www.cell.com/cell-host-mi...
@guillemsalazar.bsky.social

Global currents, microbial footprints

Marine microbial communities influence global biogeochemical cycles. In a recent Science issue, Kolody et al. integrated oceanographic measurements with high-resolution molecular sampling to show that...

Reposted by Cell Host & Microbe

Hall Lab @halllab.bsky.social · 27d

Excited to share our @cp-cellhostmicrobe.bsky.social led by Magda showing how Bif has co-evolved with different animal hosts 🐒🐭🐷🐦

Key takeaways:
🔹 Host ancestry + diet shape Bif evolution
🔹 Mammals enriched for carb-busting enzymes
🔹 Untapped diversity in non-human hosts = new probiotic potential

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 27d

Bifido adaptations across hosts

@halllab.bsky.social survey insects, reptiles, birds & mammals to uncover how Bifidobacterium adapts to hosts. Bifidobacterium & host exhibit strong co-phylogenetic associations, driven by vertical transmission & dietary selection
www.cell.com/cell-host-mi...

Host-specific microbiome and genomic signatures in Bifidobacterium reveal co-evolutionary and functional adaptations across diverse animal hosts

Bifidobacterium are beneficial members of the microbiota across animal hosts. Kujawska et al. demonstrate that bifidobacteria have likely co-evolved more closely with mammals, particularly primates, a...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 27d

Microbial matchmakers:

Pope & Tyson highlight work of @halllab.bsky.social revealing how Bifidobacterium species have co-evolved w/in various hosts, w/ diversity & host-specific metabolic adaptations shaped by evolutionary history, diet & vertical transmission
www.cell.com/cell-host-mi...

Microbial matchmakers: Bifidobacterium evolution across animal hosts

Among beneficial microbes, bifidobacteria have strong associations with health. In this issue of Cell Host & Microbe, Kujawska et al. reveal how Bifidobacterium species have co-evolved within a range ...

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 27d

Bifido adaptations across hosts

@halllab.bsky.social survey insects, reptiles, birds & mammals to uncover how Bifidobacterium adapts to hosts. Bifidobacterium & host exhibit strong co-phylogenetic associations, driven by vertical transmission & dietary selection
www.cell.com/cell-host-mi...

Host-specific microbiome and genomic signatures in Bifidobacterium reveal co-evolutionary and functional adaptations across diverse animal hosts

Bifidobacterium are beneficial members of the microbiota across animal hosts. Kujawska et al. demonstrate that bifidobacteria have likely co-evolved more closely with mammals, particularly primates, a...