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Reposted by Children's Research Institute at UT Southwestern

Peter Ly @peterlylab.bsky.social · 2h

One week left to apply!

Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · 22d

🔬 APPLY NOW: Seeking faculty scientists in #stemcells #TissueRegeneration #metabolism & #cancerbiology.

You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛

#jobs #faculty #facultyjobs #ScienceJobs 🧪

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Walter W. Chen, MD, PhD @walterwchen.bsky.social · 5d

Excited to present my research at the upcoming University of Utah Rising Stars Symposium and meet fellow scientists who love metabolism! @cri-utsw.bsky.social @rjdlab.bsky.social

uofunuip.bsky.social @uofunuip.bsky.social · Sep 8

Please join us for the Diabetes and Metabolism Research Center (DMRC) 2025 Rising Stars in partnership with the Mountain West Prevention Center (MW-PRC). This is a multi-departmental effort, aligned with the University of Utah’s synergistic approach to amplify voices and foster connections

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DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · 18d

Thank you @cri-utsw.bsky.social postdocs!

Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · 18d

We have the best postdocs! We appreciate you being a critical part of our CRI team to help discover the treatments of tomorrow. #npaw2025 #npaw #relentlessdiscovery 🧪

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · 18d

We have the best postdocs! We appreciate you being a critical part of our CRI team to help discover the treatments of tomorrow. #npaw2025 #npaw #relentlessdiscovery 🧪

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · 20d

🎉 JUST ANNOUNCED: @haozhulab.bsky.social named project co-leader for UTSW liver cancer SPORE. His project will study how to prevent hepatocellular carcinoma — which accounts for >85% of liver cancer cases across the nation.
Read more ⬇️ cri.utsw.edu/zhu-named-co...
#relentlessdiscovery 🧪

UTSW named Specialized Program of Research Excellence for liver cancer

The Liver Tumor Program at UT Southwestern Medical Center’s Harold C. Simmons Comprehensive Cancer Center has been selected by the National Cancer Institute as a Specialized Program of Research Excell...

cri.utsw.edu

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · 22d

🔬 APPLY NOW: Seeking faculty scientists in #stemcells #TissueRegeneration #metabolism & #cancerbiology.

You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛

#jobs #faculty #facultyjobs #ScienceJobs 🧪

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Reposted by Children's Research Institute at UT Southwestern

Peter Ly @peterlylab.bsky.social · 27d

Excited to join the @cri-utsw.bsky.social community to advance discoveries in genome instability. We are grateful to UTSW Pathology for 6 wonderful years.

🚨 We are also recruiting motivated postdocs to study how mitotic errors and aberrant nuclear structures drive cancer genome evolution—join us!

Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · 27d

WELCOME to the Institute, @peterlylab.bsky.social! Dr. Ly studies how cells maintain genomic integrity and how dysregulation of these processes impacts human health. 🧪Learn more about his research 👉 cri.utsw.edu/faculty/pete... #relentlessdiscovery

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · 27d

WELCOME to the Institute, @peterlylab.bsky.social! Dr. Ly studies how cells maintain genomic integrity and how dysregulation of these processes impacts human health. 🧪Learn more about his research 👉 cri.utsw.edu/faculty/pete... #relentlessdiscovery

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Aug 21

👉New article in @newscientist.com features a #relentlessdiscovery 🧪 from CRI's Agathocleous Lab ⬇️

New Scientist @newscientist.com · Aug 19

According to the textbooks, we lost the ability to make vitamin C because our diet meant that we didn't need it. But studies in animals suggest it had an unexpected benefit.

The real reason why we lost the ability to make vitamin C

The textbooks say our ancestors lost the ability to make vitamin C because we didn't need it, but the loss may have protected us from some parasites

www.newscientist.com

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Reposted by Children's Research Institute at UT Southwestern

Hijai Regina Shin @hrshin.bsky.social · Aug 13

Thrilled and deeply honored to be named a 2025 Pew Biomedical Scholar!
Huge congrats to my friend and colleague
@cri-utsw.bsky.social Javi, who’s also joining the Pew family as a Pew-Stewart Scholar.
CRI is on fire—let’s go make some bold, groundbreaking science happen! 🔥🧪✨

Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Aug 12

Congrats! 👏👏👏 Two CRI scientists named 2025 Pew-Stewart & Pew Scholars — Javier Garcia-Bermudez, Ph.D. &
@hrshin.bsky.social — to advance cancer, biomedical research 🧪 Read more about their #relentlessdiscovery ⬇️ cri.utsw.edu/two-children... @pewtrusts.org

Two Children’s Research Institute scientists named 2025 Pew Scholars - Children's Medical Center Research Institute (CRI) | Dallas Texas

Javier Garcia-Bermudez, Ph.D., Hijai Regina Shin, Ph.D., selected to advance cancer, biomedical research DALLAS – Aug. 12, 2025 – Two Children’s Medical Center Research Institute at UT Southwestern fa...

cri.utsw.edu

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Dr. Arnaldo Díaz @ajdiazphd.bsky.social · Aug 12

🎉 Huge congrats to Drs. Javier García-Bermudez and @hrshin.bsky.social for being named Pew-Stewart & Pew Scholars! Well-deserved recognition for two outstanding @cri-utsw.bsky.social scientists!

Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Aug 12

Congrats! 👏👏👏 Two CRI scientists named 2025 Pew-Stewart & Pew Scholars — Javier Garcia-Bermudez, Ph.D. &
@hrshin.bsky.social — to advance cancer, biomedical research 🧪 Read more about their #relentlessdiscovery ⬇️ cri.utsw.edu/two-children... @pewtrusts.org

Two Children’s Research Institute scientists named 2025 Pew Scholars - Children's Medical Center Research Institute (CRI) | Dallas Texas

Javier Garcia-Bermudez, Ph.D., Hijai Regina Shin, Ph.D., selected to advance cancer, biomedical research DALLAS – Aug. 12, 2025 – Two Children’s Medical Center Research Institute at UT Southwestern fa...

cri.utsw.edu

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Aug 12

Congrats! 👏👏👏 Two CRI scientists named 2025 Pew-Stewart & Pew Scholars — Javier Garcia-Bermudez, Ph.D. &
@hrshin.bsky.social — to advance cancer, biomedical research 🧪 Read more about their #relentlessdiscovery ⬇️ cri.utsw.edu/two-children... @pewtrusts.org

Two Children’s Research Institute scientists named 2025 Pew Scholars - Children's Medical Center Research Institute (CRI) | Dallas Texas

Javier Garcia-Bermudez, Ph.D., Hijai Regina Shin, Ph.D., selected to advance cancer, biomedical research DALLAS – Aug. 12, 2025 – Two Children’s Medical Center Research Institute at UT Southwestern fa...

cri.utsw.edu

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Aug 6

ONLINE NOW in @biologists.bsky.social "Disease Models & Mechanisms:" from CRI's @haozhulab.bsky.social about siRNAs for liver cancer prevention ⬇️ read more #relentlessdiscovery 🧪
journals.biologists.com/dmm/article/...

Chemoprevention for hepatocellular carcinoma using GalNAc-siRNAs

The ability to prevent hepatocellular carcinoma (HCC) in patients with chronic liver disease remains an unmet clinical need. We performed a head-to-head comparison of GalNAc-conjugated siRNA mediated ...

journals.biologists.com

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Reposted by Children's Research Institute at UT Southwestern

Walter W. Chen, MD, PhD @walterwchen.bsky.social · Aug 2

Big thanks to Jianguo Wu, Min Zhuang, @natcellbio.nature.com for a great News and Views on our work and that of Michael Skowyra, Tom Rapoport.

www.nature.com/articles/s41...

Pieces of the peroxisomal import puzzle - Nature Cell Biology

Peroxisomes are single membrane-bound organelles containing numerous enzymes to perform metabolic functions. However, our view of peroxisomal protein import has remained incomplete. Two recent studies...

www.nature.com

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Reposted by Children's Research Institute at UT Southwestern

DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Jul 30

1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by ‪@walterwchen.bsky.social‬ and a dream team of collaborators, as explained below. www.nature.com/articles/s41...

PEX39 facilitates the peroxisomal import of PTS2-containing proteins - Nature Cell Biology

Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...

www.nature.com

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Jul 30

🧵⬇️ @walterwchen.bsky.social
#relentlessdiscovery 🧪

Walter W. Chen, MD, PhD @walterwchen.bsky.social · Jul 30

Our work on new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr) is out in @natcellbio.nature.com! Equal collab w/Tony Rodrigues (Jorge Azevedo lab), @dwendscheck.bsky.social (Bettina Warscheid lab)

www.nature.com/articles/s41...

PEX39 facilitates the peroxisomal import of PTS2-containing proteins - Nature Cell Biology

Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...

www.nature.com

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Jul 30

ONLINE NOW in @natcellbio.nature.com: CRI's @rjdlab.bsky.social Lab postdoc @walterwchen.bsky.social & international colleagues have discovered the first new human peroxin in 20 years. Read more ⬇️ cri.utsw.edu/deberardinis... #relentlessdiscovery 🧪

DeBerardinis Lab discovers first human peroxin in 20 years - Children's Medical Center Research Institute (CRI) | Dallas Texas

CRI researchers, international colleagues identify PEX39, which facilitates peroxisomal protein import PEX39 is the first new human peroxisomal biogenesis protein, a peroxin or PEX, to be identified i...

cri.utsw.edu

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Jul 29

ONLINE NOW in @nature.com: latest research from CRI's @rjdlab.bsky.social Lab, full 🧵⬇️
#relentlessdiscovery 🧪

DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Jul 29

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...

Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism

Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

www.nature.com

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Jul 29

👏👏👏 Congrats to CRI grad student researcher Dylan Calhoon! He'll be presenting about the most recent #relentlessdiscovery from the Garcia-Bermudez Lab. 🧪

Weill Institute for Cell & Molecular Biology @weillinstitute.bsky.social · Jul 29

We’re thrilled to announce our Weill Institute 2025 Emerging Scholars –– eight outstanding grad students & postdocs selected for their innovative research, from institutions across the US and Canada. We'll welcome them to Cornell’s Ithaca campus Oct 13–14, 2025.
news.cornell.edu/stories/2025...

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Jul 14

ONLINE NOW: 2 new somatic mutation studies🧪 in #liver disease from CRI's @haozhulab.bsky.social
🟠 @jhepatology.bsky.social w/ postdoc Qiyu Zeng, Ph.D.
www.journal-of-hepatology.eu/article/S016...
🟠 @jclinical-invest.bsky.social w/ grad student Greg Mannino
www.jci.org/articles/vie...
⬇️Hao's thread🧵

Hao Zhu Lab at UT Southwestern @haozhulab.bsky.social · Jul 12

Introducing 2 new papers from my lab on somatic mutations in liver disease. The 1st is about a mutated gene that leads to improved clone fitness and organismal health (CIDEB). The 2nd is about a mutated gene that leads to improved clone fitness but worse overall health (TBX3). 1/8

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Reposted by Children's Research Institute at UT Southwestern

Walter W. Chen, MD, PhD @walterwchen.bsky.social · Jul 9

Excited to receive an NIH K08 Clinical Investigator Award to support my research on #mitochondria #peroxisomes 😀 The $775K will be critical in helping me transition to independence as I begin looking for a place to start my lab 🙏🏻 @the-asci.bsky.social

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DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Jul 8

Thanks Nature Cancer for the chance to reflect on some factors that led me to study cancer metabolism. For the trainees and other young scientists: the critical events that shape your career might not be obvious while they are happening. Keep an open mind and trust your instincts.

rdcu.be/evi4I

An unexpected career in cancer metabolism

Nature Cancer - Ralph DeBerardinis obtained an MD and PhD from the University of Pennsylvania, then trained in Pediatrics and Medical Genetics at Children’s Hospital of Philadelphia. He moved...

rdcu.be

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Jul 3

Research News in @theaacr.bsky.social's "Cancer Discovery" features CRI Garcia-Bermudez Lab's #relentlessdiscovery "Lipoprotein Uptake through Glycosaminoglycans Blocks Ferroptosis in Cancer" 🧪 Read more ➡️ aacrjournals.org/cdnews/news/...

Lipoprotein Uptake through Glycosaminoglycans Blocks Ferroptosis in Cancer

Major Finding: Uptake of exogenous lipoproteins through glycosaminoglycans protects cancer cells from ferroptosis.Concept: Lipoproteins inhibit ferroptosis by delivering α-tocopherol, a form of vitami...

aacrjournals.org

Reposted by Children's Research Institute at UT Southwestern

Dr. Arnaldo Díaz @ajdiazphd.bsky.social · Jul 2

We’re truly fortunate to have such extraordinary scientists engaging with our summer students. Thank you, @rjdlab.bsky.social, for sharing the groundbreaking science you are leading at @cri-utsw.bsky.social. I’m confident that your presentation inspired our students and sparked their curiosity.

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Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Jun 27

Today in @dallasnews.com by @sodendritic.bsky.social: "Dallas researchers find cancer’s secret weapon to defeat death" ⬇️ read more www.dallasnews.com/news/2025/06...
🧪 #relentlessdiscovery @rjdlab.bsky.social

Dallas researchers find cancer’s secret weapon to defeat death

Cancers use lipids to build a shield with vitamin E. Stripping that shield could lead to new treatments.

www.dallasnews.com

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