Let’s agree to disagree here. My experience is more complex and nuanced than what you are generalizing.
December 26, 2025 at 1:12 PM
Let’s agree to disagree here. My experience is more complex and nuanced than what you are generalizing.
Your large population studies contradict my own and my niece’s personal experiences. Again, MTHFR is very complex and nuanced - you can’t put a one-size-fits-all “it’s popular so it is no big deal” label on it. Individuals matter. And each experience is quite unique. Literature states that too.
December 26, 2025 at 1:10 PM
Your large population studies contradict my own and my niece’s personal experiences. Again, MTHFR is very complex and nuanced - you can’t put a one-size-fits-all “it’s popular so it is no big deal” label on it. Individuals matter. And each experience is quite unique. Literature states that too.
I see from your background that you have some experience in hereditary/genetic tumors for cancer treatment, and consultation. So I know you understand at some level this domain. So, you must understand the complexity and general lack of knowledge about MTHFR mutations, even among GPs.
December 26, 2025 at 5:20 AM
I see from your background that you have some experience in hereditary/genetic tumors for cancer treatment, and consultation. So I know you understand at some level this domain. So, you must understand the complexity and general lack of knowledge about MTHFR mutations, even among GPs.
My GP is not particularly knowledgeable about this issue so it’s been a journey for both of us. I plan to consult a geneticist with some specialization in this area. 57 years living like this, and only now realizing that this was a problem…
December 26, 2025 at 5:18 AM
My GP is not particularly knowledgeable about this issue so it’s been a journey for both of us. I plan to consult a geneticist with some specialization in this area. 57 years living like this, and only now realizing that this was a problem…
Many of these things can cause symptoms that don’t necessarily correlate with high homocysteine levels. If you heterozygous you have about a 20% decrease in your ability to process foliate. If your homozygous like me that number is closer to 80%.
December 26, 2025 at 5:14 AM
Many of these things can cause symptoms that don’t necessarily correlate with high homocysteine levels. If you heterozygous you have about a 20% decrease in your ability to process foliate. If your homozygous like me that number is closer to 80%.
This disruption of the methylation cycle disrupts, serotonin, norepinephrine and dopamine production. It can result in low red blood cell count, and low platelet count. It also disrupts the ATP cycle, the ability to create energy at the cellular level. Then that’s only part of the story.
December 26, 2025 at 5:12 AM
This disruption of the methylation cycle disrupts, serotonin, norepinephrine and dopamine production. It can result in low red blood cell count, and low platelet count. It also disrupts the ATP cycle, the ability to create energy at the cellular level. Then that’s only part of the story.
High Homocysteine is one side effect of poor B vitamin processing. There’s many more side effects of the disruption of the methylation cycle that don’t manifest in high homocysteine levels.
December 26, 2025 at 5:08 AM
High Homocysteine is one side effect of poor B vitamin processing. There’s many more side effects of the disruption of the methylation cycle that don’t manifest in high homocysteine levels.
I’ve started methylfolate supplementation, and I immediately feel greater energy, and better mood. I am taking creatine at my doctors recommendation to boost energy and she believes the creatine was masking my high homocysteine levels.
December 26, 2025 at 5:04 AM
I’ve started methylfolate supplementation, and I immediately feel greater energy, and better mood. I am taking creatine at my doctors recommendation to boost energy and she believes the creatine was masking my high homocysteine levels.
Not trying to be contrary - just saying that it’s not “nonsense” and can’t be discounted based on normal homocysteine levels. Creatine and other supplements can lower homocysteine, masking a problem with folate processing.
December 25, 2025 at 11:54 PM
Not trying to be contrary - just saying that it’s not “nonsense” and can’t be discounted based on normal homocysteine levels. Creatine and other supplements can lower homocysteine, masking a problem with folate processing.
Definitely, it’s a good start. But normal homocysteine levels should not close the door on gene testing. In my case there was a family history (my niece), and that family history was discovered through clinical depression diagnosis (after trying a few diff drugs gene testing was suggested).
December 25, 2025 at 11:51 PM
Definitely, it’s a good start. But normal homocysteine levels should not close the door on gene testing. In my case there was a family history (my niece), and that family history was discovered through clinical depression diagnosis (after trying a few diff drugs gene testing was suggested).
After some family members (my sisters kids) ended up homozygous for MTHFR 677T mutation, I go my homocysteine tested. It normally but on the high side. Doctor ordered genetic testing and turns out I’M ALSO HOMOZYGOUS.
so it didn’t “stop that nonsense”. Be careful what you suggest.
so it didn’t “stop that nonsense”. Be careful what you suggest.
December 25, 2025 at 8:12 PM
After some family members (my sisters kids) ended up homozygous for MTHFR 677T mutation, I go my homocysteine tested. It normally but on the high side. Doctor ordered genetic testing and turns out I’M ALSO HOMOZYGOUS.
so it didn’t “stop that nonsense”. Be careful what you suggest.
so it didn’t “stop that nonsense”. Be careful what you suggest.
Agree. Wish I didn’t upgrade.
December 13, 2025 at 1:38 PM
Agree. Wish I didn’t upgrade.
