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Jason Hassenstab @ctrlab.org · 25d

Thanks! And yes you are on to something with testing people under "stress" of different kinds. In another paper by my PhD student Hannah Wilks, we found that testing OAs in the evening revealed about 10% more memory deficits in those with AD pathology. pmc.ncbi.nlm.nih.gov/articles/PMC...

Sharper in the morning: Cognitive time of day effects revealed with high-frequency smartphone testing

Decades of research has established a shift from an “eveningness” preference to a “morningness” preference with increasing age. Accordingly, older adults typically have better cognition in morning hou...

pmc.ncbi.nlm.nih.gov

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Jason Hassenstab @ctrlab.org · 25d

Overall, we think it sends a pretty positive message about the validity of remote, unsupervised #digitalcognition #EMA, in general. But of course we have to collect information about environments and especially distractions.

Jason Hassenstab @ctrlab.org · 25d

One surprise was that the number of sessions where participants reported distractions was about 12% of sessions. So distractions are very very common and its really important to allow participants to tell you when they experience them in remote studies. 4/n

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Jason Hassenstab @ctrlab.org · 25d

However, for those with very mild dementia (consistent with Mild Cognitive Impairment), environments and distractions started to matter more. Taking tests away from home AND when around others impacted those with cognitive symptoms. 3/n

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Jason Hassenstab @ctrlab.org · 25d

We followed 380 cognitively normal (CN) older adults and 37 with very mild dementia with our smartphone #EMA platform called ARC. For the CNs, it didn't seem to matter if tests were taken at home or around others. Even sessions where overt distractions were experienced didn't matter. 2/n

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Jason Hassenstab @ctrlab.org · 25d

New paper from the lab. First author @mwelhaf.bsky.social, now in a TT position at North Carolina A&T. We wanted to know how environmental contexts and self-reported distractions impacted cognitive #EMA in older adults. mhealth.jmir.org/2025/1/e71578 1/n

Impacts of Environmental Distractions and Interruptions on Unsupervised Digital Cognitive Assessments in Older Adults: Cognitive Ecological Momentary Assessment Study

Background: Unsupervised cognitive assessments are becoming commonly used in studies of aging and neurodegenerative diseases. Because assessments are completed in everyday environments and without a p...

mhealth.jmir.org

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Reposted by Jason Hassenstab

NPR @npr.org · Apr 1

Some 2,000 scientists, including dozens of Nobel Prize winners, have signed an open letter warning that the U.S. lead in science is being "decimated" by the Trump administration's cuts to research.

Top scientists warn that Trump policies are causing a 'climate of fear' in research

Some 2,000 scientists, including dozens of Nobel Prize winners, have signed an open letter warning that the U.S. lead in science is being "decimated" by the Trump administration's cuts to research.

www.npr.org

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Reposted by Jason Hassenstab

Alzheimer's & Dementia Journals @alzdemjournals.bsky.social · Mar 31

The ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI) revolutionizes in vivo characterization of mixed pathologies #AlzResearch

Learn about this unprecedented publicly available imaging–plasma–neuropath dataset in A&D:
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI)

The presence of multiple pathologies is the largest predictor of dementia. A major gap in the field is the in vivo detection of mixed pathologies and their antecedents. The Alzheimer's Disease Resea...

alz-journals.onlinelibrary.wiley.com

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Reposted by Jason Hassenstab

St. Louis Post-Dispatch @stltoday.com · Mar 20

Washington University-led research shows a small group of participants in an Alzheimer’s study experienced a significant delay in the onset of symptoms.

St. Louis study shows that drug may prevent Alzheimer’s. NIH slowdowns threaten future research

Washington University-led research shows a small group of participants in an Alzheimer’s study experienced a significant delay in the onset of symptoms.

www.stltoday.com

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Reposted by Jason Hassenstab

WashU Medicine @washumedicine.bsky.social · Mar 20

"This treatment has given me an extension to my life that I never banked on having." A groundbreaking Alzheimer’s study led by WashU Medicine researchers shows promise in delaying symptom onset that could change the lives of those genetically at risk. apnews.com/article/alzh...

Researchers find a hint at how to delay Alzheimer's symptoms. Now they have to prove it

An experimental treatment appears to postpone Alzheimer's symptoms in some people genetically destined to get the disease at a young age.

apnews.com

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Reposted by Jason Hassenstab

Bryan D. James, PhD @bryandjames.bsky.social · Mar 20

Had a fantastic time visiting @ctrlab.org in STL, presenting at the Washington University Aging & Development seminar, watching Dr. Hassenstab kick a$$ teaching Psych students, great dinner with Wash U friends and finishing off with a brewery tour! Whirlwind couple of days. Thanks Jason!

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Jason Hassenstab @ctrlab.org · Mar 12

This is amazing. Thanks!

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Jason Hassenstab @ctrlab.org · Mar 12

Great resources here for those of us interested in Ecological Momentary Assessment #EMA #ENDALZ

Eiko Fried @eikofried.bsky.social · Mar 12

Are you doing EMA research and wonder how to go about it? In recent work we've adressed some open questions and challenges, here is a brief summary of papers and materials.

🧵 #PsychSciSky 🧪 #StatsSky

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Reposted by Jason Hassenstab

Magdalena Skipper @magdalenaskipper.bsky.social · Feb 20

Trump’s siege of science: how the first 30 days unfolded & what’s next

Once upon a time leaders believed that science was essential to nation’s security, to better health, to more jobs, to a higher standard of living & to cultural progress
🧪 #academicSky
@nature.com
www.nature.com/articles/d41...

Trump’s siege of science: how the first 30 days unfolded and what’s next

The breakneck pace and devastating impact of the administration’s policy changes has shocked researchers.

www.nature.com

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Jason Hassenstab @ctrlab.org · Feb 19

LOL Just like STL. Don't you miss us?

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Reposted by Jason Hassenstab

Jetske van der Schaar @jetskes.bsky.social · Feb 14

So humbled to be recognized as Distinguished Finalist for the Bold Pioneer Award...! Congrats to my fellow winners, and many thanks to prof Scheltens, prof Hassenstab, @washuneurology.bsky.social , and everyone who has encouraged me. It means a lot to me! 💜 @ctrlab.org
tinyurl.com/boldpioneer

Jiang-Xie selected for 2024 WashU Medicine Bold Pioneer Award | Neurology | Washington University in St. LouisWashU Medicine

neurology.wustl.edu

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Jason Hassenstab @ctrlab.org · Feb 14

Definitely worth a read. #endalz www.statnews.com/2025/02/14/a...

There is no ‘amyloid cabal’ in Alzheimer’s research

“There exists no ‘amyloid cabal’” in Alzheimer’s research, neurologist Dennis Selkoe writes in response to Charles Piller’s “Doctored.”

www.statnews.com

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Reposted by Jason Hassenstab

Bryan D. James, PhD @bryandjames.bsky.social · Feb 11

The entire landscape of medical research is shifting on an hour to hour basis. The whiplash is stupefying. As of now (Monday evening) the NIH 15% cap on indirects has been halted by a judge in 22 states but who knows what tomorrow brings www.statnews.com/2025/02/10/n...

Federal judge halts Trump administration cuts to NIH research payments in 22 states

Attorneys general sued the Trump administration to block a NIH decision that would slash grant payments for research overhead

www.statnews.com

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Jason Hassenstab @ctrlab.org · Feb 11

chng.it/WJznM2Lzgp
Let’s go!!!

This campaign needs you now

Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

chng.it

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Jason Hassenstab @ctrlab.org · Feb 11

Alzheimer’s disease is non-partisan. Cancer is non-partisan. Diabetes is non-partisan. This is a short-sighted policy that could cost thousands of jobs and set biomedical research progress back by years. Contact your local representatives and urge them to stand against this dangerous policy.

What The NIH Cut To Indirect Cost Payments Could Cost Red States

The Trump administration’s decision to cap how much NIH will pay for indirect costs on university research grants would cost 10 red states more than $1 billion.

www.forbes.com

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Reposted by Jason Hassenstab

Nico Dosenbach @ndosenbach.bsky.social · Jan 2

The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧵 ⬇️

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Jason Hassenstab @ctrlab.org · Dec 31

Great info here! Focusing on women's brain health is key for solving #Alzheimers disease #ENDALZ. From one of my good friends @bucklr01.bsky.social 🧠 🧪. Plus her 🇦🇺 accent makes everything sound optimistic 🦘.

Rachel Buckley, PhD @bucklr01.bsky.social · Dec 31

Check out my new podcast ep on CVL!

open.spotify.com/episode/5oda...

Why Women's Brain Health Deserves a Closer Look in Alzheimer's Research with Dr. Rachel Buckley

The CVL Podcast · Episode

open.spotify.com

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Jason Hassenstab @ctrlab.org · Dec 30

Critical findings from my man @bryandjames.bsky.social at Rush Alzheimer's Disease Research Center. Social activities may delay dementia onset by 5 years. That delay could result in $500,000 savings in healthcare costs. #ENDALZ #Alzheimer's

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Late‐life social activity and subsequent risk of dementia and mild cognitive impairment

INTRODUCTION Social activity is associated with better cognitive health in old age. To better translate epidemiological research for public health communication, we estimated relations of levels of .....

alz-journals.onlinelibrary.wiley.com

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Jason Hassenstab @ctrlab.org · Dec 19

I must have sent out 30-40 requests. Thank you!!

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