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Carolien van de Sandt

@cvandesandt.bsky.social

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Carolien van de Sandt @cvandesandt.bsky.social · Nov 30

How does antiviral #immunity against #influenza evolve across human lifespan? 👶➡️👧➡️👱➡️👵
Our study in Nature Immunology investigates the difference in CD8 T cell response across human lifespan - a🧵⬇️ go.unimelb.edu.au/627s
Katherine Kedzierska, Fabio Luciani, The Doherty Institute

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Carolien van de Sandt @cvandesandt.bsky.social · 26d

Great work by @chinweetan.bsky.social , @Len Dalit and @groomlab.bsky.social and her team understanding the signatures behind T folicular helper heterogeneity! ⬇️

#ImmunoSky

Joanna Groom @groomlab.bsky.social · 27d

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...

This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social

Thread below...

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology

Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

www.nature.com

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Carolien van de Sandt @cvandesandt.bsky.social · Jul 25

And thanks to our funders:
@nhmrc.bsky.social, The Australian Research Council, the NIH, the Clifford Craig Foundation, Marie Skłodowska-Curie Actions, The University of Melbourne

Carolien van de Sandt @cvandesandt.bsky.social · Jul 25

Thanks everybody who contributed:
Hayley McQuilten, Jerome Samir, Oanh Nguyen, Ratana Lim, Jasveen Kaur, Simone Rizzetto, Auda Eltahla, Paul Thomas, Martha Lappas, Jamie Rossjohn, Stephanie Gras, Jane Crowe, Katie Flanagan, Fabio Luciani , Peter Doherty, @katherinekedz.bsky.social

Carolien van de Sandt @cvandesandt.bsky.social · Jul 25

Tejas also wrote a great lay version which can be found at the @thedohertyinst.bsky.social website: www.doherty.edu.au/news-events/...

Thanks for the memories: How killer T cells protect us from the flu throughout life

With influenza season underway in Australia, researchers at the Doherty Institute are working to better understand how the immune system responds to these infections and how its protection changes as we age.

www.doherty.edu.au

Carolien van de Sandt @cvandesandt.bsky.social · Jul 25

📢 Very proud to present @tejas-the-tcell.bsky.social 2nd First Author paper published in @pnas.org where he showed that key #TCR repertoires & gene expression profiles can be found in #influenza CD8 T central memory cell pools across the human lifespan. #AgingResearch
doi.org/10.1073/pnas.2501167122

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

doi.org

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Reposted by Carolien van de Sandt

Tejas Menon @tejas-the-tcell.bsky.social · Jul 23

Thanks for the memories! Proud to have our study on central memory CD8+ T cells across the human lifespan published in PNAS today!
You can read our paper: go.unimelb.edu.au/rp7p
Or our article: go.unimelb.edu.au/jp7p
@thedohertyinst.bsky.social‬ @cvandesandt.bsky.social‬ @katherinekedz.bsky.social‬

Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan | PNAS

Central memory CD8+ T cells (Tcm) represent the prominent memory T cell subset in human blood, yet the persistence of T cell receptor (TCR) clonoty...

go.unimelb.edu.au

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Reposted by Carolien van de Sandt

ESWI @eswinfluenza.bsky.social · Jun 20

🚨 #ESWI2025 🚨 Key upcoming deadlines
🐦 Early bird registration ends on 30 June 2025
🚀 Extra call for abstracts in #Molecular #Virology open until 31 July 2025
🚀 Late breaker abstract submission is open until 10 August eswiconference.org/abstract-sub...

Carolien van de Sandt @cvandesandt.bsky.social · May 24

📢Very proud to present @jetvddijssel.bsky.social her final paper for her PhD in @eurjimmunol.bsky.social where we used the latest #Nanovial technology to activate CD8 T cells and link their TCRs to IFNy levels without the need to fix them! doi.org/10.1002/eji.... @thedohertyinst.bsky.social @Sanquin

Linking Epitope‐Specific T‐Cell Receptors to IFNγ Secretion Using Nanovial Technology

To link IFNγ-secretion levels of epitope-specific T-cells with their TCRαβ, we coated nanovials with pHLA-I to capture and activate epitope-specific T-cells and their secreted IFNγ, followed by index...

onlinelibrary.wiley.com

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Reposted by Carolien van de Sandt

ESWI @eswinfluenza.bsky.social · Apr 24

🗓️ Only 3 weeks to go! 📍#ESWI2025
📆 20–23 October 2025 | Valencia, Spain
📝 Abstract submission deadline: 16 May 2025
🚨 Don’t miss your chance to contribute to the largest European #scientific conference on #Influenza & #AcuteRespiratoryVirus diseases
eswiconference.org/abstract-sub...

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Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

#Openaccess

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

This study was supported by
#nhmrc, #arc_gov_au, #MSCActions, #EU_H2020

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

This study was a multi-institute collaboration between @thedohertyinst.bsky.social, @UniMelb, @whofluccmelb.bsky.social , @latrobeuni.bsky.social , @monashuniversity.bsky.social

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

We would like to thank all our collaborators on this work @HayleyMcQuilten, @MaletAban, @OanhNguyen, @SophieValkenburg @EmmaGrant, @SnehaSant, @JamieRossjohn, @graslab.bsky.social , @JaneCrowe

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

Conclusion: Public A2/M158-specific TCR clonotypes are long-lived. We identified a window of opportunity between 30-40 years of age, when optimal public TCRs and/or public-associated clonotypes could be boosted through novel vaccinations, so they can be maintained to older age.

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

We demonstrated that the lower probability of generation of older TCRb chains underpins the decrease in TCR similarity within the A2M1-specific TCRab repertoire of older adults over time.

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

Decline in adults public TCRs is compensated by expansion of similar TCRs which express public CDR3 motifs with strong avidity for A2M1. Older TCR repertoires lack public-CDR3 motifs, resulting in expansion of low similar TCRs with private CDR3 motifs & lower avidity for A2M1.

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

Young public clonotypes (associated with higher functionality) and older private clonotypes (associated with lower functionality) are long-lived and can be detected over the course of 12 years but gradually decline over time.

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

Adult TCR repertoires were relative stable across timepoints, the limited diversity resulted from broader TCRa gene usage. Heterogenic changes were observed in older TCR repertoires across timepoints, both the TCRa & TCRb chain contribute to diversifying older TCR repertoires.

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

We defined influenza-specific CD8 T cell immunity over 12 years directly ex vivo in cohort of adults & older adults. T cells were directed at the prominent/conserved HLA-A*02:01-restricted M1(58–66) peptide derived from influenza A viruses (A2M1)

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

T Time’s Up, when the immune system is getting older, it gradually loses its top team players
A brief lay summary of our work can be found here: doherty.edu.au/news-events/news/t-times-up-when-the-immune-system-is-getting-older-it-gradually-loses-its-top-team-players
#SciComm

Carolien van de Sandt @cvandesandt.bsky.social · Apr 24

Your immune system gradually loses it top team players when we get older 👱➡️👵
Our study in @ebiomedicine.bsky.social investigates how long good immune cells stay around – a 🧵⬇️ go.unimelb.edu.au/4sep
@katherinekedz.bsky.social @thedohertyinst.bsky.social #Influenza #AgingResearch #Immunity #TCR

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Carolien van de Sandt @cvandesandt.bsky.social · Mar 17

Congratulations!!

Carolien van de Sandt @cvandesandt.bsky.social · Mar 13

@ImmunologyNews #SARS-CoV-2 #COVID #SciComm #Openacces #Ageingresearch

Carolien van de Sandt @cvandesandt.bsky.social · Mar 13

This study was a multi-institute collaboration between @Sanquin @amsterdamumc.bsky.social @thedohertyinst.bsky.social @unilibrary.bsky.social @champalimaudf.bsky.social and was supported by @arc_gov_au

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Carolien van de Sandt @cvandesandt.bsky.social · Mar 13

We would like to thank all our collaborators on this work, including @hammarieke.bsky.social and those without Bluesky