"we identified that PC(O-38:4) had significantly reduced levels in ME/CFS LCLs and was almost entirely discriminative of ME/CFS status"

#MECFS generated lymphoblastoid cell lines "show accumulation of lipids, skewed lipid profiles and altered activity of related metabolic enzymes such as PTDSS1."

@davetuller1.bsky.social has also written on this at

virology.ws/2025/12/11/t...

and

virology.ws/2025/12/16/t...

"The brutal truth is this: living with PEM means making impossible choices every single day. Work or social life. Basic functioning or relationships. Today’s activity or tomorrow’s capacity."

-- Fred Rossi (@darthfoo.bsky.social)

New in this release

- Heart rate zones display
- More monthly metrics, eg walking and stair speed, stability
- Interface improvements
- iOS 26 compatibility

One of the identified genes is SUDS3 which is proposed to be linked to microglial activation.

https://www.pure.ed.ac.uk/ws/portalfiles/portal/533352484/Candidate_Genes.pdf