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Derek Mann @damann1.bsky.social · Aug 14

China town!

Derek Mann @damann1.bsky.social · Jul 6

As Newcastle University’s Professor of Hepatology, I am honoured and extremely proud to be a contributor to its world top 10 ranking in Gastroenterology and Hepatology 👊

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Reposted by Derek Mann

Newcastle University Centre for Cancer @nucancer.bsky.social · Jun 16

The NU Conference was a big success with a superb plenary from Ram DasGupta (CRUK Scotland). Prizes for talks - J Dishington (1st) and H Stewart; flash talks - E Woodward (1st), L Taylor (2nd); posters - E Hackney (1st), K Papa (2nd). Congrats and to all presenters for giving us a memorable day!

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Derek Mann @damann1.bsky.social · Apr 22

Spectacular 3 days in Singapore. Everyone should visit

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Derek Mann @damann1.bsky.social · Apr 8

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Derek Mann @damann1.bsky.social · Mar 27

Very excited to be just a weekend away from this UK conference on neutrophil biology that we are hosting at Newcastle. It includes international keynotes but most important the majority of speakers are early career researchers. #immunology #inflammation #neutrophils #humandisease

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Derek Mann @damann1.bsky.social · Mar 14

Our latest paper, published today in FEBS Letters is a chemical biology study on development of drugs selectively targeting HDAC6 with demonstration of efficacy in a human model of liver fibrosis. febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press

Chronic liver injury can lead to severe conditions such as cirrhosis and liver cancer. Unfortunately, there are no effective treatments to halt or reverse liver fibrosis, which makes new therapeutic ....

febs.onlinelibrary.wiley.com

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Derek Mann @damann1.bsky.social · Feb 27

Wow, phenomenal work. 75% of pancreatic cancer patients alive 3 years after receiving a personalised mRNA vaccine. Durable CD8+ T cell responses underlying the therapeutic benefit. Congrats to the authors 👊👏

www.nature.com/articles/s41...

RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer - Nature

In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked lo...

www.nature.com

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Derek Mann @damann1.bsky.social · Feb 21

Dr Amy Collins from our group and @nucancer.bsky.social selected for early career researcher oral presentation of her poster on use of a complex human tissue culture model of liver cancer for drug development.

Derek Mann @damann1.bsky.social · Feb 20

Next up, our talented PhD student Keara, who was super busy at her poster on development of a tumour slice screening platform for discovery of liver cancer drug targets.

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Derek Mann @damann1.bsky.social · Feb 20

Dr Amy Collins is busy at her poster on modelling hepatocellular carcinoma at the 2025 EASL Liver Cancer Summit in Paris. Funding for her work from Cancer Research U.K.

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Reposted by Derek Mann

Newcastle University Centre for Cancer @nucancer.bsky.social · Feb 19

An important new study on the genetics of liver cancer published today in Nature led by Prof Tom Bird of Edinburgh University with contributions from @damann1.bsky.social, @jleslie1.bsky.social and others of @nucancer.bsky.social.

As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in ...

www.nature.com

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Derek Mann @damann1.bsky.social · Feb 11

Well done Keara, very proud of you!

Newcastle University Centre for Cancer @nucancer.bsky.social · Feb 11

Our talented PhD student Keara wins a regional prize for her work on developing a 96-well scale model of liver cancer tumour microenvironment. Congratulations Keara!

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Derek Mann @damann1.bsky.social · Feb 4

The Cure. Somber, Sad, Glorious (and oh that bass!) 😊

THE CURE It Can Never Be The Same @ Meltdown Festival, London 6/24/18

YouTube video by citizenborland

youtu.be

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Derek Mann @damann1.bsky.social · Feb 4

On World Cancer Day we welcome Dr Abdullah Malik to our liver cancer team. Abdullah is a talented surgeon who has won a prestigious Medical Research Council clinician scientist training fellowship to research the basis of recurrence of cancer following surgical removal of a patient’s tumour.

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Derek Mann @damann1.bsky.social · Feb 4

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Reposted by Derek Mann

Newcastle University Centre for Cancer @nucancer.bsky.social · Feb 4

Today is World Cancer Day. At the NU Centre for Cancer we are dedicated to working towards more effective and gentler treatments for cancer patients.

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Derek Mann @damann1.bsky.social · Jan 11

The graph is reporting a decline in published works. That is not the same as leaving a research career.

Derek Mann @damann1.bsky.social · Jan 10

Others have said the same. Maybe a new career move if and when the funding dries up 🤣

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Derek Mann @damann1.bsky.social · Jan 10

🤣

Derek Mann @damann1.bsky.social · Jan 10

In addition to my trials and tribulations with bowel cancer I also suffer from pre-cancerous lesions on the skin around my eyes. So now have a new pair of wraparound prescription shades to offer a better degree of protection. Not sure if I look more like The Terminator or a character from The Matrix

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Reposted by Derek Mann

Newcastle University Centre for Cancer @nucancer.bsky.social · Jan 2

We are very proud that our very own Professor Christine Harrison has been deservedly recognised with an OBE for her work on improving the scientific knowledge and care of childhood leukaemia. bloodcancer.org.uk/news/blood-c...

Blood Cancer UK | Blood cancer researcher recognised in King’s New Years Honours

The King’s New Years Honours list has been announced with Blood Cancer UK's trustee awarded an OBE for services to children.

bloodcancer.org.uk

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Derek Mann @damann1.bsky.social · Dec 29

Hmmm yes, Dylan may have have some genius moments but he is obviously a bit of a knob

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Derek Mann @damann1.bsky.social · Dec 24

Keep going and wishing you happy holidays and good health in 2025

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Derek Mann @damann1.bsky.social · Dec 18

Our brain is not a computer

“Why does the brain need billions of neurons to process 10bits/sec? Why can we only think about one thing at a time?”

Fascinating paper makes me wonder if aspects of neurodivergence (e.g. ADHD) are the brain trying to be a little faster?

arxiv.org/abs/2408.10234

The Unbearable Slowness of Being: Why do we live at 10 bits/s?

This article is about the neural conundrum behind the slowness of human behavior. The information throughput of a human being is about 10 bits/s. In comparison, our sensory systems gather data at ~10^...

arxiv.org

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