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Reposted by Daniela Robles-Espinoza

Simon Fisher @profsimonfisher.bsky.social · 4d

Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350....
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪

Image shows the first two printed pages of the paper “A forkhead-domain gene is mutated in a severe speech and language disorder” by Cecilia Lai and colleagues, published in Nature in 2001 (volume 413, pages 519-523). The abstract reads as follows:
Individuals affected with developmental disorders of speech and language have substantial difficulty acquiring expressive and/or receptive language in the absence of any profound sensory or neurological impairment and despite adequate intelligence and opportunity. Although studies of twins consistently indicate that a significant genetic component is involved, most families segregating speech and language deficits show complex patterns of inheritance, and a gene that predisposes individuals to such disorders has not been identified. We have studied a unique three-generation pedigree, KE, in which a severe speech and language disorder is transmitted as an autosomal-dominant monogenic trait. Our previous work mapped the locus responsible, SPCH1, to a 5.6-cM interval of region 7q31 on chromosome 7. We also identified an unrelated individual, CS, in whom speech and language impairment is associated with a chromosomal translocation involving the SPCH1 interval. Here we show that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is directly disrupted by the translocation breakpoint in CS. In addition, we identify a point mutation in affected members of the KE family that alters an invariant amino-acid residue in the forkhead domain. Our findings suggest that FOXP2 is involved in the developmental process that culminates in speech and language.

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · 4d

Fascinating story!!! Thanks for sharing, enjoyed reading it a lot 😄

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Reposted by Daniela Robles-Espinoza

The BMJ @bmj.com · 6d

Despite regulation, commercial sunbeds remain popular with young people and indoor tanning is experiencing a boom in popularity.

An outright ban of sunbeds is likely to be cost effective for the NHS, says this Analysis
www.bmj.com/content/391/...

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Reposted by Daniela Robles-Espinoza

Edward Elderman @elderman.bsky.social · 12d

This only happens to you once

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · 21d

Come join us next year at the @embo.org meeting "The Many Faces of #Cancer evolution"! Organised by @ciriellolab.bsky.social @magnanilab.bsky.social @turajliclab.bsky.social & Céline Vaillot! In beautiful Rimini 🇮🇹

More information in the poster below ⬇️ and at

meetings.embo.org/event/26-cancer-evo

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Reposted by Daniela Robles-Espinoza

c0nc0rdance @c0nc0rdance.bsky.social · 26d

"We present exciting and novel new findings on the topic of the gel I'm about to run, with confirmatory experiments I'll run next Tuesday..."

"Submitting an abstract without all the data collected" and it's the facade of a building without any actual building behind it. A white apartment complex module or something with a freight entrance or garage door and some sliding glass doors, but it's just sky behind it.

Stolen from the Internet.

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Reposted by Daniela Robles-Espinoza

FlyBase @flybase.bsky.social · Aug 15

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

FlyBase:Contribute to FlyBase - FlyBase Wiki

wiki.flybase.org

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Reposted by Daniela Robles-Espinoza

Christian Kost @kostchristian.bsky.social · Aug 8

I am excited to announce that the position of a senior postdoc (3 +3 years) in the field of theoretical biology is available in my group.

The position provides the opportunity to closely interact with experimentalists and develop own research projects.

Please RT.

Details 👇:
shorturl.at/iiiOv

116 FB 5 Research Assistant (m/f/d) field of Theoretical Ecology and Evolution or Computational Biology: Uni Osnabrück

shorturl.at

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 22

Muchas felicidades Fernando y equipo! Increíble trabajo 😀😀😀

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Reposted by Daniela Robles-Espinoza

Fernando Villanea @fervillanea.bsky.social · Aug 21

Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science!

This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).

www.science.org/doi/10.1126/...

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection

We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...

www.science.org

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Reposted by Daniela Robles-Espinoza

Tulio de Oliveira @tuliodna.bsky.social · Aug 20

Here my advice for young scientists: while technical and lab expertise are vital, core skills such as writing for non-specialists can open new doors - from securing grants to creating broader impact for scientific publications. See #RealTalkResearch series - youtu.be/Tu4bl3PJPHQ?...

Which Skills Help Scientists Succeed Beyond the Lab? Writing skills! #RealTalkResearch 3 :

YouTube video by CERI & KRISP Centre Epidemic Response & Innovation

youtu.be

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 19

Please consider supporting our students! The only Latin American team 🇲🇽 in BIOMOD, an international #science competition. They worked on an innovative treatment for colon cancer using nanotechnology & DNA origami 🧬🔬

Learn more!
youtu.be/GV0cnb3biJQ?...

Donate:
crowdfunding.tec.mx/s/detallepro...

Biotecnología sin Fronteras: Nanotecnología Mexicana

YouTube video by Biomod

youtu.be

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 18

We are super happy to host Miguel García-Knight @levelab.bsky.social at @liigh-unam.bsky.social today! He's talking about the intriguing work on virus characterisation and surveillance he's doing in Mexico 🇲🇽 at IIB-UNAM

Check out the call for participants for the Global Culicidae project!! ⬇️

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 13

Amazing new work from @patriciapossik.bsky.social's group!!! Check it out - An amazing repository and characterisation including PDXs, sequencing, cell lines - with new biological insights! #acralmelanoma

medRxivpreprint @medrxivpreprint.bsky.social · Aug 12

Modelling Acral Melanoma in Admixed Brazilians Uncovers Genomic Drivers and Targetable Pathways https://www.medrxiv.org/content/10.1101/2025.08.08.25332963v1

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Reposted by Daniela Robles-Espinoza

lcgej.bsky.social @lcgej.bsky.social · Aug 11

New semester, new bluesky account!
We start this new semester at UNAM welcoming new and current students of the Genomic Sciences Undergraduate Program at UNAM in Juriquilla!

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 11

This is really cool! Congratulations! Also @delvecchyo.bsky.social you will enjoy this!!

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 9

🤣🤣🤣

Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 9

"Access to a PhD-level expert in your pocket"

I'd like to have a word with ChatGPT's PhD advisor please

I'd like them to tell me about their discovery of the cyτlasma and the centrosome/lysosmoe duality

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 9

It drew the state boundaries fairly accurately I think but then completely mislabeled the states and created new ones 😅

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 9

This explains why Tlaxcala finally conquered central Mexico after their attempts at telling people that they DO exist! (This image is from an actual government campaign 😂)

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 9

I imagine Querétaro's new name Is Quetzarr? Though we seem to have been conquered by Tlaxcala. The ultimate vengeance for the "state that doesn't exist"

I also enjoy Quezacala, Nora and Ijalislo a lot. Hope to visit some day.

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 9

"Access to a PhD-level expert in your pocket"

Prompt: Can you make me a map of Mexico with the names of all states? can you list them after the image as well?

I was born in the great state of Cusidad le Mexico. We're proud of our French origins. Also I see Yucatan finally took over its neighbours

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 8

You can do it!! Sending best wishes and good vibes - teach those robots how to count 💪🏽

a robot with a smiley face on its face is holding a binary sphere

ALT: a robot with a smiley face on its face is holding a binary sphere

media.tenor.com

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 8

Follow up question why are you awake? Because celebrity?

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Daniela Robles-Espinoza @daniela-oaks.bsky.social · Aug 8

How do you deal with the trolls Theo

Also- super interesting though couldn't replicate after a few tries :p

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