Daniel Ojeda
@danojedajuarez.bsky.social
Scientists doing research on Prion and Alzheimer’s Disease.
The latest @radiolab.bsky.social on neuron organoids is a masterclass in why serendipity is the core to scientific discovery. Chasing strange phenomena can yield huge breakthroughs. 🧠🧵
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January 10, 2026 at 10:29 PM
The latest @radiolab.bsky.social on neuron organoids is a masterclass in why serendipity is the core to scientific discovery. Chasing strange phenomena can yield huge breakthroughs. 🧠🧵
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(1/2)
Reposted by Daniel Ojeda
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
January 6, 2026 at 11:29 PM
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
Happy New Year! May 2026 bring you fewer projects, more publications, and p-values < 0.05. May you breeze past Reviewer #3 and finally achieve that much-needed work-life balance. 🥂✨ #Science #AcademicLife #NewYear
January 1, 2026 at 4:23 PM
Happy New Year! May 2026 bring you fewer projects, more publications, and p-values < 0.05. May you breeze past Reviewer #3 and finally achieve that much-needed work-life balance. 🥂✨ #Science #AcademicLife #NewYear
Reposted by Daniel Ojeda
A life-sciences job in Boston used to be a sure path to a high-paying career, but empty labs and unemployed grads now herald tougher times in the city.
🔗: on.wsj.com/4jmIwvd
🔗: on.wsj.com/4jmIwvd
December 31, 2025 at 1:09 AM
A life-sciences job in Boston used to be a sure path to a high-paying career, but empty labs and unemployed grads now herald tougher times in the city.
🔗: on.wsj.com/4jmIwvd
🔗: on.wsj.com/4jmIwvd
This @wsj.com article highlights the slowdown in Boston, but anecdotally other biotech hubs, such as San Diego and San Francisco, are facing similar downturns 📉. Is this the usual "boom and bust" cycle, or a structural shift in the industry and waning US science support?🤔
www.wsj.com/tech/biotech...
www.wsj.com/tech/biotech...
Ph.D.s Can’t Find Work as Boston’s Biotech Engine Sputters
A life-sciences job in Boston used to be a sure path to a high-paying career, but empty labs and unemployed grads now herald tougher times in the city.
www.wsj.com
December 30, 2025 at 6:49 AM
This @wsj.com article highlights the slowdown in Boston, but anecdotally other biotech hubs, such as San Diego and San Francisco, are facing similar downturns 📉. Is this the usual "boom and bust" cycle, or a structural shift in the industry and waning US science support?🤔
www.wsj.com/tech/biotech...
www.wsj.com/tech/biotech...
2025 has been a marathon of a year:
• 2 co-authored papers 📚
• 1 preprint 📄
• Oral presentation at Prion2025 🇧🇷
•Presented at @ucsdmedschool.bsky.social
• 4 grant apps submitted 📝
...all while chasing an energetic toddler. 🏃♂️
Ready for 2026! ☕️☕️
#AcademicSky #Science
• 2 co-authored papers 📚
• 1 preprint 📄
• Oral presentation at Prion2025 🇧🇷
•Presented at @ucsdmedschool.bsky.social
• 4 grant apps submitted 📝
...all while chasing an energetic toddler. 🏃♂️
Ready for 2026! ☕️☕️
#AcademicSky #Science
December 26, 2025 at 8:47 PM
2025 has been a marathon of a year:
• 2 co-authored papers 📚
• 1 preprint 📄
• Oral presentation at Prion2025 🇧🇷
•Presented at @ucsdmedschool.bsky.social
• 4 grant apps submitted 📝
...all while chasing an energetic toddler. 🏃♂️
Ready for 2026! ☕️☕️
#AcademicSky #Science
• 2 co-authored papers 📚
• 1 preprint 📄
• Oral presentation at Prion2025 🇧🇷
•Presented at @ucsdmedschool.bsky.social
• 4 grant apps submitted 📝
...all while chasing an energetic toddler. 🏃♂️
Ready for 2026! ☕️☕️
#AcademicSky #Science
New updates from NIH to tackle application backlogs:
1. Meetings cut to one day; only the top 30-35% are discussed.
2. The top third, and middle third ("competitive but NOT discussed") will both considered for funding
3. Scores released fast; simplified Summary Statements later. #NIH #ScienceFunding
1. Meetings cut to one day; only the top 30-35% are discussed.
2. The top third, and middle third ("competitive but NOT discussed") will both considered for funding
3. Scores released fast; simplified Summary Statements later. #NIH #ScienceFunding
December 16, 2025 at 9:22 PM
New updates from NIH to tackle application backlogs:
1. Meetings cut to one day; only the top 30-35% are discussed.
2. The top third, and middle third ("competitive but NOT discussed") will both considered for funding
3. Scores released fast; simplified Summary Statements later. #NIH #ScienceFunding
1. Meetings cut to one day; only the top 30-35% are discussed.
2. The top third, and middle third ("competitive but NOT discussed") will both considered for funding
3. Scores released fast; simplified Summary Statements later. #NIH #ScienceFunding
2025 has been a roller coaster 🎢, from the lowest lows to the highest heights.
But I can always trust that the elevator to my lab at @ucsandiego.bsky.social breaks down at least once a month. At this point, I'm convinced it's the university's secret initiative to keep its scientists in shape 😅
But I can always trust that the elevator to my lab at @ucsandiego.bsky.social breaks down at least once a month. At this point, I'm convinced it's the university's secret initiative to keep its scientists in shape 😅
December 15, 2025 at 6:34 AM
2025 has been a roller coaster 🎢, from the lowest lows to the highest heights.
But I can always trust that the elevator to my lab at @ucsandiego.bsky.social breaks down at least once a month. At this point, I'm convinced it's the university's secret initiative to keep its scientists in shape 😅
But I can always trust that the elevator to my lab at @ucsandiego.bsky.social breaks down at least once a month. At this point, I'm convinced it's the university's secret initiative to keep its scientists in shape 😅
The first nonprofit-led gene therapy just won FDA approval for Wiskott-Aldrich syndrome, a win for patients, but also a cautionary tale. Many gene therapies aren’t financially sustainable, and companies are abandoning them.
www.fiercepharma.com/pharma/itali...
www.fiercepharma.com/pharma/itali...
Italian nonprofit lands FDA approval for 1st gene therapy to treat rare genetic disease
The FDA has issued its stamp of approval to a new, cell-based option to treat Wiskott-Aldrich syndrome (WAS), marking the first therapy of its kind for the rare disease and making Italy’s Fondazion | ...
www.fiercepharma.com
December 13, 2025 at 3:35 AM
The first nonprofit-led gene therapy just won FDA approval for Wiskott-Aldrich syndrome, a win for patients, but also a cautionary tale. Many gene therapies aren’t financially sustainable, and companies are abandoning them.
www.fiercepharma.com/pharma/itali...
www.fiercepharma.com/pharma/itali...
I had a great time attending my first prion conference. I was honored to be selected to present my work, and it has been an amazing experience meeting other researchers and developing collaborations! #prion2025
November 6, 2025 at 12:42 PM
I had a great time attending my first prion conference. I was honored to be selected to present my work, and it has been an amazing experience meeting other researchers and developing collaborations! #prion2025
Lovely quote I heard from a fellow PhD today “The only thing I hate more than being forced to learn new things is teaching them...” 😱😱 #somepeople
October 22, 2025 at 10:54 PM
Lovely quote I heard from a fellow PhD today “The only thing I hate more than being forced to learn new things is teaching them...” 😱😱 #somepeople
The strides for CJD event and the CJD foundation are vital for supporting families, funding researchers, and raising physician awareness. I was glad to join Drs. Sigurdson and Rajic from @ucsdhealthsci.bsky.social to discuss our research and progress in treatment at the #Strides4CJD in San Diego.
October 5, 2025 at 6:55 PM
The strides for CJD event and the CJD foundation are vital for supporting families, funding researchers, and raising physician awareness. I was glad to join Drs. Sigurdson and Rajic from @ucsdhealthsci.bsky.social to discuss our research and progress in treatment at the #Strides4CJD in San Diego.
These @radiolab.bsky.social episodes highlight how curiosity-driven science can lead to real-world impact. I truly believe they should be required listening in schools. They teach the reality of the slow, steady march of scientific progress.
🎧
bit.ly/3EqqSGV
vist.ly/3m2ryne
🎧
bit.ly/3EqqSGV
vist.ly/3m2ryne
Golden Goose
Radiolab · Episode
bit.ly
April 25, 2025 at 11:04 PM
These @radiolab.bsky.social episodes highlight how curiosity-driven science can lead to real-world impact. I truly believe they should be required listening in schools. They teach the reality of the slow, steady march of scientific progress.
🎧
bit.ly/3EqqSGV
vist.ly/3m2ryne
🎧
bit.ly/3EqqSGV
vist.ly/3m2ryne
Just had that weirdly delightful moment where @radiolab.bsky.social started interviewing someone from my PhD institute, @sbpdiscovery.bsky.social
Gotta love when the science world feels small in the best way.
#STEM #PhDLife #SciencePodcasts
open.spotify.com/episode/4Elq...
Gotta love when the science world feels small in the best way.
#STEM #PhDLife #SciencePodcasts
open.spotify.com/episode/4Elq...
The Age of Aquaticus
Radiolab · Episode
open.spotify.com
April 25, 2025 at 10:22 PM
Just had that weirdly delightful moment where @radiolab.bsky.social started interviewing someone from my PhD institute, @sbpdiscovery.bsky.social
Gotta love when the science world feels small in the best way.
#STEM #PhDLife #SciencePodcasts
open.spotify.com/episode/4Elq...
Gotta love when the science world feels small in the best way.
#STEM #PhDLife #SciencePodcasts
open.spotify.com/episode/4Elq...
Fantastic work from our lab:
In press at @jclinical-invest.bsky.social, we show that a single amino acid mutation in the prion protein alters NMDAR activity leading to rapid neurodegeneration without triggering aggregate formation. 🧠🧪
www.jci.org/articles/vie...
In press at @jclinical-invest.bsky.social, we show that a single amino acid mutation in the prion protein alters NMDAR activity leading to rapid neurodegeneration without triggering aggregate formation. 🧠🧪
www.jci.org/articles/vie...
JCI -
Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice
www.jci.org
April 6, 2025 at 6:18 PM
Fantastic work from our lab:
In press at @jclinical-invest.bsky.social, we show that a single amino acid mutation in the prion protein alters NMDAR activity leading to rapid neurodegeneration without triggering aggregate formation. 🧠🧪
www.jci.org/articles/vie...
In press at @jclinical-invest.bsky.social, we show that a single amino acid mutation in the prion protein alters NMDAR activity leading to rapid neurodegeneration without triggering aggregate formation. 🧠🧪
www.jci.org/articles/vie...
Excited to share my latest preprint studying prion disease. (🧵)
PrPC-induced signaling in human neurons activates phospholipase Cγ1 and an Arc/Arg3.1 response
www.biorxiv.org/content/10.1...
PrPC-induced signaling in human neurons activates phospholipase Cγ1 and an Arc/Arg3.1 response
www.biorxiv.org/content/10.1...
www.biorxiv.org
April 6, 2025 at 3:35 PM
Excited to share my latest preprint studying prion disease. (🧵)
PrPC-induced signaling in human neurons activates phospholipase Cγ1 and an Arc/Arg3.1 response
www.biorxiv.org/content/10.1...
PrPC-induced signaling in human neurons activates phospholipase Cγ1 and an Arc/Arg3.1 response
www.biorxiv.org/content/10.1...
Reposted by Daniel Ojeda
PrPC-induced signaling in human neurons activates phospholipase Cγ1 and an Arc/Arg3.1 response https://www.biorxiv.org/content/10.1101/2025.04.01.645054v1
April 5, 2025 at 11:15 PM
PrPC-induced signaling in human neurons activates phospholipase Cγ1 and an Arc/Arg3.1 response https://www.biorxiv.org/content/10.1101/2025.04.01.645054v1
Reposted by Daniel Ojeda
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
March 22, 2025 at 10:44 AM
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
For every $1 spent by NIH, $2.56 was generated in return and supported over 400,000 jobs. Funding #science is one of the best investments a country can make!
www.forbes.com/sites/michae...
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 15, 2025 at 2:25 AM
For every $1 spent by NIH, $2.56 was generated in return and supported over 400,000 jobs. Funding #science is one of the best investments a country can make!
www.forbes.com/sites/michae...
www.forbes.com/sites/michae...
March 7, 2025 at 9:06 PM
Biomedical research in San Diego is an engine of innovation and cures. It's time to show the world that people value the contributions of science and scientists! Please join "Stand Up for Science" at UCSD. #researchsaveslives
@kpbssandiego.bsky.social @standupforscience.bsky.social
@kpbssandiego.bsky.social @standupforscience.bsky.social
March 7, 2025 at 3:32 AM
Biomedical research in San Diego is an engine of innovation and cures. It's time to show the world that people value the contributions of science and scientists! Please join "Stand Up for Science" at UCSD. #researchsaveslives
@kpbssandiego.bsky.social @standupforscience.bsky.social
@kpbssandiego.bsky.social @standupforscience.bsky.social
Congratulations to the Kaul lab @ucriverside.bsky.social for their recent publication looking at the long-term effects of chronic low-dose methamphetamine in NeuroHIV. This was one of the first projects I contributed to during my PhD. It is great to see it finally published!
March 1, 2025 at 2:21 PM
Congratulations to the Kaul lab @ucriverside.bsky.social for their recent publication looking at the long-term effects of chronic low-dose methamphetamine in NeuroHIV. This was one of the first projects I contributed to during my PhD. It is great to see it finally published!
Freezing NIH funding will have consequences for everyone, not only scientists, from cancer treatments to pandemic preparedness to advancements in dementia. @standupforscience.bsky.social is organizing a rally to show our support for science on March 7, 2025 @ucsandiego.bsky.social
February 28, 2025 at 6:48 PM
Freezing NIH funding will have consequences for everyone, not only scientists, from cancer treatments to pandemic preparedness to advancements in dementia. @standupforscience.bsky.social is organizing a rally to show our support for science on March 7, 2025 @ucsandiego.bsky.social
Reposted by Daniel Ojeda
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
February 12, 2025 at 5:04 PM
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence