Darren Martin
@darrenmartin.bsky.social
In a nutshell within a nutshell: broaden your experience if you want to increase your creativity.
December 19, 2025 at 2:41 PM
In a nutshell within a nutshell: broaden your experience if you want to increase your creativity.
A hypothesis/point of view that I find appealing at a personal level (meaning its probably bullshit). In a nutshell its this: the breadth/range of your problem-solving experience/training hones an analogizing skill which makes it easier for you to solve superficially unrelated new problems.
December 19, 2025 at 2:36 PM
A hypothesis/point of view that I find appealing at a personal level (meaning its probably bullshit). In a nutshell its this: the breadth/range of your problem-solving experience/training hones an analogizing skill which makes it easier for you to solve superficially unrelated new problems.
Did you maybe post a link to the wrong video? In this one he only mentions Intubation at ~0:30 and at this point he definitely doesn't say anything about doctors killing patients by intubation. Thought maybe you accidentally linked to it because the video's heading is so misleading.
December 19, 2025 at 1:10 PM
Did you maybe post a link to the wrong video? In this one he only mentions Intubation at ~0:30 and at this point he definitely doesn't say anything about doctors killing patients by intubation. Thought maybe you accidentally linked to it because the video's heading is so misleading.
I don't know. I would guess though that, yes, an important feature of life is processes that trade energy to spatially control local reductions in entropy over time. Its a really big question though that I'm too stupid to answer properly.
December 18, 2025 at 1:21 PM
I don't know. I would guess though that, yes, an important feature of life is processes that trade energy to spatially control local reductions in entropy over time. Its a really big question though that I'm too stupid to answer properly.
sorry should have read "all ORFs downstream of ORF 8 also look BA3.2 like".
December 13, 2025 at 9:11 AM
sorry should have read "all ORFs downstream of ORF 8 also look BA3.2 like".
Yeah but it seems as though there is JN.1 sequence upstream of ORF7. and all ORFs downstream of ORF 8 also look JN.1 like.
December 12, 2025 at 10:00 PM
Yeah but it seems as though there is JN.1 sequence upstream of ORF7. and all ORFs downstream of ORF 8 also look JN.1 like.
If its real the JN1 parent would have also had ORF7b and ORF8 deleted. Could be that there has been a misassembly due to the lab using a BA.3.2 template sequence to assemble these new sequences (because using a sequence without the deletion messes up the assembly of "normal" BA.3.2 sequences).
December 12, 2025 at 9:57 PM
If its real the JN1 parent would have also had ORF7b and ORF8 deleted. Could be that there has been a misassembly due to the lab using a BA.3.2 template sequence to assemble these new sequences (because using a sequence without the deletion messes up the assembly of "normal" BA.3.2 sequences).
Nevertheless, maybe that hypothetical parent "knows" something we don't and that bit of ORF7 provides some key advantage and this is, in fact exactly the sort of recombinant Ryan suspects might emerge.
December 12, 2025 at 9:20 PM
Nevertheless, maybe that hypothetical parent "knows" something we don't and that bit of ORF7 provides some key advantage and this is, in fact exactly the sort of recombinant Ryan suspects might emerge.
The only way to explain there being a partial restoration of ORF7 would be if the parent virus itself also had only just this small fragment of ORF7 present and the breakpoint is somewhere upstream of ORf7.
December 12, 2025 at 9:18 PM
The only way to explain there being a partial restoration of ORF7 would be if the parent virus itself also had only just this small fragment of ORF7 present and the breakpoint is somewhere upstream of ORf7.
That shouldn't be possible - Homologous recombination requires homology at recombination breakpoint sites. The proposed recombination breakpoint site in the deleted tract of sequences does not exist (its been deleted).
December 12, 2025 at 9:15 PM
That shouldn't be possible - Homologous recombination requires homology at recombination breakpoint sites. The proposed recombination breakpoint site in the deleted tract of sequences does not exist (its been deleted).
One sublineage of the BA3.2's lurking in Australia also has a six nt deletion in this spot (one of the "QT" residues is gone) - seems kind've convergent @ryanhisner.bsky.social ?
November 23, 2025 at 9:05 PM
One sublineage of the BA3.2's lurking in Australia also has a six nt deletion in this spot (one of the "QT" residues is gone) - seems kind've convergent @ryanhisner.bsky.social ?
He seems pretty harmless to me. But maybe, like him, I'm just a dumbass, and you're right: we should all keep our big dumbass mouths shut and let the clever people do all the talking.
November 21, 2025 at 3:27 PM
He seems pretty harmless to me. But maybe, like him, I'm just a dumbass, and you're right: we should all keep our big dumbass mouths shut and let the clever people do all the talking.
Standouts for me are Tyler, King, Food for Thought and Madam Medusa. Even if you think you don't like reggae, or if you think that UB40 were too commercial, you should still be able to appreciate that these are pretty fucking good songs. I have a soft spot for One in Ten from Present Arms too.
October 25, 2025 at 8:31 PM
Standouts for me are Tyler, King, Food for Thought and Madam Medusa. Even if you think you don't like reggae, or if you think that UB40 were too commercial, you should still be able to appreciate that these are pretty fucking good songs. I have a soft spot for One in Ten from Present Arms too.
Wow - this is really cool. Love that you zoomed straight in on natural variants. Is there a firm estimate yet for the proportion of spontaneously arising mutations (i.e. non-natural variants) in these genes that are deleterious? In yeast generally, even synonymous subs are often deleterious, right?
October 25, 2025 at 7:56 PM
Wow - this is really cool. Love that you zoomed straight in on natural variants. Is there a firm estimate yet for the proportion of spontaneously arising mutations (i.e. non-natural variants) in these genes that are deleterious? In yeast generally, even synonymous subs are often deleterious, right?
If it wasn't for the blip in Jan 2024 I'd guess it might be something like a sexually transmitted frog, toad or fish picornavirus. Regardless, you should check the rRNA and see if you get an associated peak for some kind of animal rRNA at that time.
October 24, 2025 at 7:48 PM
If it wasn't for the blip in Jan 2024 I'd guess it might be something like a sexually transmitted frog, toad or fish picornavirus. Regardless, you should check the rRNA and see if you get an associated peak for some kind of animal rRNA at that time.
Do you really mean you're hearing Patrick Stewart? Sort of the same but maybe better? I'd just go with Laszlo though.
October 11, 2025 at 9:50 AM
Do you really mean you're hearing Patrick Stewart? Sort of the same but maybe better? I'd just go with Laszlo though.
I think this may be the one: patents.google.com/patent/US200...
US20090030925A1 - Clustering phylogenetic variation patterns
- Google Patents
Data clustering is described for determining related components of the data. In one example, information on biomolecules may be clustered into groups in which the biomolecular data in a clustered grou...
patents.google.com
September 29, 2025 at 5:56 PM
I think this may be the one: patents.google.com/patent/US200...
I vaguely recall that Microsoft's bioinformatics peeps in Seattle tried (maybe successfully - I don't even know/care) to patent phylogenetic tree construction about 20 years ago. Happy for Tableau to waste some money on stupid shit though.
September 29, 2025 at 10:12 AM
I vaguely recall that Microsoft's bioinformatics peeps in Seattle tried (maybe successfully - I don't even know/care) to patent phylogenetic tree construction about 20 years ago. Happy for Tableau to waste some money on stupid shit though.
but...but...but.... their moms must have taken Tylenol for them to have such obvious autism spectrum things going....right? Or am I just saying stupid things again?
September 23, 2025 at 4:44 PM
but...but...but.... their moms must have taken Tylenol for them to have such obvious autism spectrum things going....right? Or am I just saying stupid things again?
For me joining always types out as joing - ratio almost always types out as ration for me too BTW. I thought it was probably a "muscle memory" thing that has preserved some mistakes i commonly made while I was learning to type. Might just be dementia though.
September 17, 2025 at 2:44 PM
For me joining always types out as joing - ratio almost always types out as ration for me too BTW. I thought it was probably a "muscle memory" thing that has preserved some mistakes i commonly made while I was learning to type. Might just be dementia though.
..a game where, in reality, neither risks nor rewards are ever known with any degree of certainty, where over-promising is rewarded more than under-delivering is penalized (it is easy to make excuses for "risky" work failing), and where funders cannot tell how novel/boring eventual outputs are.
September 14, 2025 at 3:37 PM
..a game where, in reality, neither risks nor rewards are ever known with any degree of certainty, where over-promising is rewarded more than under-delivering is penalized (it is easy to make excuses for "risky" work failing), and where funders cannot tell how novel/boring eventual outputs are.