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daspliceisright.bsky.social
Burge Lab
@daspliceisright.bsky.social
69 followers 49 following 4 posts
We study gene expression & RNA processing (RBPs, splicing, transcription) using experimental and computational methods at @MITBiology! for older posts, see our profile on X: https://x.com/daSpliceIsRight
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daspliceisright.bsky.social
Burge Lab @daspliceisright.bsky.social · Mar 7
Chris and our lab members (pictured here), along with many other labs from MIT Biology Dept, came out to protest today during "Stand Up for Science" day!! Keep it up @standupforscience.bsky.social
four scientists outside state house of MA, smiling, posing for a selfie during a protest
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daspliceisright.bsky.social
Burge Lab @daspliceisright.bsky.social · Mar 6
Congrats to Burge lab alumna Dr. Kowal: her work on intron mediated enhancement (IME) of gene expression is officially published in Nucleic Acids Research!

academic.oup.com/nar/article/...
Sequence-dependent and -independent effects of intron-mediated enhancement learned from thousands of random introns
Abstract. Spliceosomal introns are a ubiquitous feature of eukaryotic genes, whose presence often boosts the expression of their host gene, a phenomenon kn
academic.oup.com
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daspliceisright.bsky.social
Burge Lab @daspliceisright.bsky.social · Feb 20
Here is the research article, published today in Nature Communications:

www.nature.com/articles/s41...
LUC7 proteins define two major classes of 5′ splice sites in animals and plants - Nature Communications
Non-coding introns are excised from RNA transcripts of most eukaryotic genes by splicing. Here, Kenny et al. show that LUC7 proteins promote the splicing of different subsets of introns with distinct ...
www.nature.com
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daspliceisright.bsky.social
Burge Lab @daspliceisright.bsky.social · Feb 20
Congrats to Burge Lab PhD Student Connor Kenny on receiving an MIT news feature, highlighting his graduate work, uncovering how the LUC7 class of proteins control subclasses of RNA splicing events:

news.mit.edu/2025/mit-bio...

@mitnews
MIT biologists discover a new type of control over RNA splicing
MIT biologists discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts.
news.mit.edu
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